Results 11 to 20 of about 391,042 (189)

Biochemical Characterization of a Kunitz-Type Protease Inhibitor From Mimosa regnellii and Its Effects on Melanoma Cell Viability and Angiogenesis. [PDF]

Chem Biodivers
A Kunitz‐type serine protease inhibitor (JTI) purified from Mimosa regnellii seeds selectively targets melanoma cells. JTI triggers mitochondrial apoptosis, increases ROS and Ca2+ levels, arrests the cell cycle, and suppresses migration and angiogenesis without affecting healthy cells.
Rabêlo LMA, Cardoso PHO, Nobre LTDB, Dos Santos PIM, Lucena SV, Serquiz RP, Bemquerer MP, Rocha HAO, Nader HB, Dos Santos EA, de Oliveira AS, Frihling BEF, Migliolo L.   +12 more
europepmc   +2 more sources

Integration of genome-wide association studies and gene coexpression networks unveils promising soybean resistance genes against five common fungal pathogens

Scientific Reports, 2021
Soybean is one of the most important legume crops worldwide. However, soybean yield is dramatically affected by fungal diseases, leading to economic losses of billions of dollars yearly.
Fabricio Almeida-Silva, Thiago M. Venancio   +1 more
doaj   +1 more source

Evaluation of four different strategies to characterize plasma membrane proteins from banana roots [PDF]

, 2015
Plasma membrane proteins constitute a very important class of proteins. They are involved in the transmission of external signals to the interior of the cell and selective transport of water, nutrients and ions across the plasma membrane.
Carpentier, Sebastien C., García, S., Panis, B., Swennen, Rony L.   +3 more
core   +1 more source

Purification of a fragment obtained by autolysis of a PIIIb-SVMP from Bothrops alternatus venom [PDF]

, 2018
Snake Venom Metalloproteinases (SVMPs) represent 43.1% of the components in Bothrops alternatus venom and play an important role in envenomation. Disintegrins and disintegrin-like domains are released by proteolytic processing of PII and PIII classes of ...
Acosta, Ofelia Cristina, Biscoglio, Mirtha Josefa, Bustillo, Soledad, dos Santos, Patty Karina, Gay, Claudia Carolina, Leiva, Laura Cristina Ana, Olivera Moritz, Milene Nobrega de, Rodríguez, Juan Pablo, Sobreiro Selistre de Araujo, Heloisa, Van de Velde, Andrea Carolina   +9 more
core   +1 more source

Partial purification of peptides present in the Tityus macrochirus (Buthidae) scorpion venom and preliminary assessment of their cytotoxicity

Biomédica: revista del Instituto Nacional de Salud, 2017
Introduction: Scorpion venom contains peptides with neurotoxic action primarily active on ion channels in the nervous system of insects and mammals. They are also characterized as cytolytic and anticancer, biological characteristics that have not yet ...
Clara Andrea Rincón-Cortés, Edgar Antonio Reyes-Montaño, Nohora Angélica Vega-Castro   +2 more
doaj   +1 more source

Computational Perspectives into Plasmepsins Structure—Function Relationship: Implications to Inhibitors Design

Journal of Tropical Medicine, 2011
The development of efficient and selective antimalariais remains a challenge for the pharmaceutical industry. The aspartic proteases plasmepsins, whose inhibition leads to parasite death, are classified as targets for the design of potent drugs ...
Alejandro Gil L., Pedro A. Valiente, Pedro G. Pascutti, Tirso Pons   +3 more
doaj   +1 more source

Padrões de acúmulo de proteínas e carboidratos durante a embriogênese somática de Acca sellowiana [PDF]

, 2009
The aim of this work was to quantify the protein, starch and total sugars levels during histodifferentiation and development of somatic embryos of Acca sellowiana Berg.
Cangahuala-Inocente, Gabriela Claudia, Guerra, Miguel Pedro, Maldonado, Sara Beatriz, Steiner, Neusa   +3 more
core   +3 more sources

Sticholisina II encapsulada en liposomas potencia una respuesta de linfocitos T citotóxicos específica al antígeno

Anales de la Academia de Ciencias de Cuba, 2021
Introducción: Las estrategias vacunales para potenciar respuestas de linfocitos T CD8+ citotóxicos (CTL) constituyen un reto debido a la necesidad de favorecer la presentación cruzada de antígenos (Ag) exógenos por las células presentadoras de antígenos (
María Eliana Lanio Ruiz, Rady Judith Laborde Quintana, Yoelys Cruz Leal, Luis Enrique Fernández Molina, Oraly Sánchez Ferrás, Anaixis del Valle, Isbel Lopetegui González, María C. Luzardo Lorenzo, Carlos Álvarez Valcárcel, Circe Mesa   +9 more
doaj  

Brain glutaminases

Biomolecular Concepts, 2010
Glutaminase is considered as the main glutamate producer enzyme in brain. Consequently, the enzyme is essential for both glutamatergic and gabaergic transmissions.
Márquez Javier, Martín-Rufián Mercedes, Segura Juan A., Matés José M., Campos-Sandoval José A., Alonso Francisco J.   +5 more
doaj   +1 more source

Comparação das respostas celulares imunes induzidas por proteínas filtradas da cultura de Mycobacterium tuberculosis

Revista Portuguesa de Pneumologia, 2002
ABSTRACTBlastogenic responses and cytokine production induced by two culture filtrates of Mycobacterium tuberculosis collected at different time points were compared in donors with pulmonary tuberculosis and healthy Mantoux-positive BCG vaccinated controls. The short term culture filtrate proteins (ST-CFP) induced stronger IFN-γ production than the mid
Diane J. Ordway, H. Silveira, L. Costa, S. Costa, M. Martins, R. Badura, M.J. Arroz, H.M. Dockrell, S. Young, F.A.A.N. Ventura   +9 more
openaire   +2 more sources