Suppression of signal transducer and activator of transcription 3-dependent B lymphocyte terminal differentiation by BCL-6 [PDF]
, 2000 Lymphocytes usually differentiate into effector cells within days after antigen exposure, except in germinal centers where terminal differentiation is delayed while somatic hypermutation creates high-affinity antibody mutants. Here we investigate whether
Peakman, LJ +14 more
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Roles of Bcl-3 in the pathogenesis of murine type 1 diabetes [PDF]
, 2010 OBJECTIVE: It has long been recognized that autoimmunity is often associated with immunodeficiency. The mechanism underlying this paradox is not well understood.
Ruaidhri J. Carmody +9 more
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, 2023 (A) The BCL-2-regulated apoptotic pathway involves the following proteins pro-survival BCL-2 proteins, pro-apoptotic BH3-only proteins, and apoptosis effectors BAX/BAK proteins. Lines indicate interactions between molecules. (B) In healthy cells, the pro-
Nathaniel Chien (14636956) +6 more
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Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1. [PDF]
, 2012 Melanoma is an often fatal form of skin cancer which is remarkably resistant against radio- and chemotherapy. Even new strategies that target RAS/RAF signaling and display unprecedented efficacy are characterized by resistance mechanisms.
Berking, Carola +18 more
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Molecular Interactions of Prodiginines with the BH3 Domain of Anti-Apoptotic Bcl-2 Family Members. [PDF]
, 2013 Prodigiosin and obatoclax, members of the prodiginines family, are small molecules with anti-cancer properties that are currently under preclinical and clinical trials. The molecular target(s) of these agents, however, is an open question.
Ali Hosseini (383134) +26 more
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Ets-2 is a target for an Akt (protein kinase B)/Jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice [PDF]
, 2000 The transcription factor ets-2 was phosphorylated at residue threonine 72 in a colony-stimulating factor 1 (CSF-1)- and mitogen-activated protein kinase-independent manner in macrophages isolated from motheaten-viable (me-v) mice.
Forsthoefel, David +16 more
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Pramanicin analog induces apoptosis in human colon cancer cells: critical roles for Bcl-2, Bim, and p38 MAPK signaling [PDF]
, 2013 Pramanicin (PMC) is an antifungal agent that was previously demonstrated to exhibit antiangiogenic and anticancer properties in a few in vitro studies. We initially screened a number of PMC analogs for their cytotoxic effects on HCT116 human colon cancer
Karslı, Gizem +23 more
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Bcl-2 inhibitors: small molecules with a big impact on cancer therapy
, 2009 Despite tremendous advances over the last 15 years in understanding fundamental mechanisms of apoptosis, this has failed to translate into improved cancer therapy for patients. However, there may now be light at the end of this long tunnel. Antiapoptotic
M Vogler +7 more
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Evaluation of bcl-2, bax and c-erbB-2 Levels in Chronic Otitis Patients with or without Cholesteatoma [PDF]
, 2015 Objective:The aim of this study was to evaluate bcl-2, bax, and c-erbB-2 expressions in primary and secondary acquired cholesteatoma and to indicate the role of apoptosis and accompanying increased cellular proliferation in the pathogenesis of ...
Emrah Sapmaz +7 more
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Regulación de la familia de proteínas BCL-2 en células infectadas con Chlamydia trachomatis [PDF]
, 2015 <p>El presente artículo revisa los mecanismos inhibitorios de la apoptosis usados por <em>Chlamydia trachomatis (Ct) </em>frente a la familia de proteínas Bcl-2, para lograr su supervivencia intracelular. <em>Chlamydia trachomatis
Alejandra Mantilla Galindo +5 more
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