Results 21 to 30 of about 39,105,044 (67)

Bcl-xL is the only anti-apoptotic Bcl-2 family member necessary for survival during KSHV latent infection.

, 2023
(A) TIME cells were transduced with the indicated sgRNAs and selected as before and were subsequently mock or KSHV infected. Cell viability was measured with a trypan blue assay 48 hpi.
Michael Lagunoff (143637), Lyndsey N. Moore (15447690), Daniel L. Holmes (15447693), Joselyn Landazuri Vinueza (15447696), Anjali Sharma (538603)   +4 more
core   +1 more source

IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?

, 2005
Current understanding of IGF-I-mediated neuroprotection implies the activation of phosphatidylinositol-3-kinase (PI-3K), which leads to the activation of Akt/Protein Kinase B.
Brugg, B., Arbez, N., Willaime-Morawek, S., Mariani, J.   +3 more
core   +1 more source

Proto-oncogene c-jun expression is induced by AML1-ETO in a JNK dependent manner:possible role in the pathogenesis of acute myeloid leukemia [PDF]

, 2003
Overexpression of proto-oncogene c-jun and constitutive activation of the Jun NH2-terminal kinase (JNK) signaling pathway have been implicated in the leukemic transformation process.
Elsaesser, Annika
core   +1 more source

Estudo do efeito neuroprotetor da mirtazapina e imipramina e sua relação com a expressão gênica de proteínas apoptóticas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Neste estudo foram investigados a ação neuroprotetora dos antidepressivos mirtazapina e imipramina e os efeitos ...
Lieberknecht, Vicente
core  

Importância da investigação de proteínas de resistência ABCB1, ABCC1 e LRP e da proteína antiapoptótica Bcl-2 no diagnóstico e no prognóstico de leucemias agudas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2010A resistência a múltiplas drogas é uma das maiores causas para a falha do tratamento das leucemias ...
Moraes, Ana Carolina Rabello de
core  

Function of BID - a molecule of the bcl-2 family - in ischemic cell death in the brain [PDF]

, 2002
Mitochondrial mechanisms, particularly the release of cytochrome c, play a role in the death of nerve and glial cells in cerebral ischemia. We have currently investigated whether BID, a proapoptotic molecule of the bcl-2 family and promoter of the ...
Amin-Hanjani, Sepideh, Qiu, Jianhua, Moskowitz, Michael A., Zinkel, Sandra, Korsmeyer, Stanley J., Plesnila, Nikolaus   +5 more
core   +1 more source

Bcl-2 regulates amplification of caspase activation by cytochrome c [PDF]

, 1999
Caspases, a family of specific proteases, have central roles in apoptosis [1]. Caspase activation in response to diverse apoptotic stimuli involves the relocalisation of cytochrome c from mitochondria to the cytoplasm where it stimulates the proteolytic ...
Clarke, PR, Cosulich, SC, Peter J. Savory, Cosulich, Sabina C., Savory, Peter J., Paul R. Clarke, Clarke, Paul R., Savory, PJ, Sabina C. Cosulich   +8 more
core   +1 more source

bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer

, 1999
Tumour angiogenesis has been recently recognised as one of the most important prognostic factors in lung cancer. Although a variety of angiogenic factors have been identified, the angiogenesis process remains poorly understood.
Giatromanolaki, A., O'Byrne, K. J., Koukourakis, M. I., Gatter, K. C., O'Byrne, Kenneth J., Krammer, B., Harris, A. L., Jiles, C., Cox, J.   +8 more
core   +1 more source

Bcl-2-Ome - a database and interactive web service for dissecting the Bcl-2 interactome.

, 2017
Hantusch A, Brunner T, Frickey T, Rehm M.Bcl-2-Ome - a database and interactive web service for dissecting the Bcl-2 interactome. Cell death & differentiation.
Markus Rehm (7899308), Tancred Frickey (41953), Annika Hantusch (1856422), Thomas Brunner (828760)   +3 more
core   +2 more sources

Glatiramer acetate induces pro-apoptotic mechanisms involving Bcl-2, Bax and Cyt-c in peripheral lymphocytes from multiple sclerosis patients

, 2006
Apoptotic deletion of autoreactive T-cells is defective in patients with multiple sclerosis (MS). Glatiramer acetate (GA) treatment seems to restore apoptosis of detrimental T-cells.
RUGGIERI, Maddalena, LIVREA, Paolo, SCACCO, Salvatore, TROIANO, Maria, Avolio C, Pica C, Lia A, Zimatore GB, Papa S   +8 more
core   +1 more source