Results 201 to 210 of about 216,280 (242)
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Protease-activated receptors in the musculoskeletal system
The International Journal of Biochemistry & Cell Biology, 2008Protease-activated receptors (PARs) mediate cellular responses to a subset of extracellular proteases, including blood coagulation factors and proteases produced by inflammatory cells. Cells in bone, cartilage and muscle exhibit cell type-specific expression patterns and functional responses for the different PARs. Activators of PAR-1 include thrombin,
E J, Mackie +7 more
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Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer
Cellular and Molecular Life Sciences, 2013Mammalian protease-activated-receptor-1 and -2 (PAR1 and PAR2) are activated by proteases found in the flexible microenvironment of a tumor and play a central role in breast cancer. We propose in the present study that PAR1 and PAR2 act together as a functional unit during malignant and physiological invasion processes.
Mohammad, Jaber +7 more
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Pathophysiological actions of protease activated receptors (PARs)
Die Pharmazie, 2007Serine proteases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example, are highly active mediators with diverse biological activities. So far, proteases have been considered to act primarily as degradative enzymes in the extracellular space.
Pandya, Naushira +2 more
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Agonists and Antagonists of Protease Activated Receptors (PARs)
Current Medicinal Chemistry, 2006Protease activated receptors (PARs) are a category of G-protein coupled receptors (GPCRs) implicated in the progression of a wide range of diseases, including thrombosis, inflammatory disorders, and proliferative diseases. Signal transduction via PARs proceeds via an unusual activation mechanism.
Barry, GD, Le, GT, Fairlie, DP
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Protease-activated Receptors in Vascular Biology
Thrombosis and Haemostasis, 2001SummaryG protein-coupled protease-activated receptors (PARs) provide one answer to the question of how coagulation factors and other proteases regulate cellular behaviors. In concert with the coagulation cascade, these receptors provide an elegant mechanism that links mechanical information in the form of tissue injury or vascular leak to cellular ...
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Neurochemical Journal, 2010
Extracellular serine proteases are implicated in numerous processes in the brain, both under normal and pathological conditions. Many of the effects of these proteases are mediated by protease-activated receptors (PARs). PARs are a unique class of receptors widely expressed in many tissues, including the brain.
O. N. Davydova, A. A. Yakovlev
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Extracellular serine proteases are implicated in numerous processes in the brain, both under normal and pathological conditions. Many of the effects of these proteases are mediated by protease-activated receptors (PARs). PARs are a unique class of receptors widely expressed in many tissues, including the brain.
O. N. Davydova, A. A. Yakovlev
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The Cardiovascular Actions of Protease-Activated Receptors
Molecular Pharmacology, 2005Protease-activated receptors (PARs) comprise a family of G protein-coupled receptors with a unique proteolytic activation mechanism. PARs are activated by thrombin or other coagulation or inflammatory proteases formed at sites of tissue injury. PARs play a particularly important role in the pathogenesis of clinical disorders characterized by chronic ...
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Regulating protease activated Receptor 2
2014Protease-Activated Receptors (PARs) belong to an unusual family of G Protein Coupled Receptors (GPCRs). Each of the four known members is activated by its own N-terminus exposed by proteolytic cleavage and there is no other endogenous agonist known to date.
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Protease-Activated Receptors and Platelet Function
Thrombosis and Haemostasis, 1999IntroductionPlatelet activation is critical for normal hemostasis, and platelet-dependent arterial thrombosis underlies most myocardial infarctions. Thrombin is the most potent activator of platelets.1,2 For this reason, understanding the process by which thrombin activates platelets is necessary for understanding hemostasis and thrombosis and may ...
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