Results 11 to 20 of about 943,189 (296)
Molecular Therapy: Oncolytics, 2023 Glioblastoma (GBM) is the most common aggressive malignant brain cancer and is chemo- and radioresistant, with poor therapeutic outcomes. The “double-edged sword” of virus-induced cell death could be a potential solution if the oncolytic virus ...
Yu-Ting Kao +5 more
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Frontiers in Molecular Biosciences, 2021 Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an unprecedented target for antibiotic therapy 15 years ago when it was ...
Heike Brötz-Oesterhelt +2 more
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Viruses, 2022 Alphaviruses are positive-strand RNA viruses, mostly being mosquito-transmitted. Cells infected by an alphavirus become resistant to superinfection due to a block that occurs at the level of RNA replication. Alphavirus replication proteins, called nsP1-4,
Liubov Cherkashchenko +4 more
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Beyond Inhibition: A Novel Strategy of Targeting HIV-1 Protease to Eliminate Viral Reservoirs
Viruses, 2022 HIV-1 protease (PR) is a viral enzyme that cleaves the Gag and Gag-Pol polyprotein precursors to convert them into their functional forms, a process which is essential to generate infectious viral particles.
Josh G. Kim, Liang Shan
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Food Technology and Biotechnology, 2015 The objectives of this study are to optimize the conditions for providing high yield of NaCl-tolerant extracellular protease from Virgibacillus sp. SK37 based on a fi sh-based medium and to investigate the eff ects of the key factors (mass per volume ...
Sornchai Sinsuwan +4 more
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Cryptococcal Protease(s) and the Activation of SARS-CoV-2 Spike (S) Protein
Cells, 2022 In this contribution, we report on the possibility that cryptococcal protease(s) could activate the SARS-CoV-2 spike (S) protein. The S protein is documented to have a unique four-amino-acid sequence (underlined, SPRRAR↓S) at the interface between the S1
Nozethu Mjokane +7 more
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Molecules, 2022 The Escherichia coli chaperonin GroEL/ES (GroE) is one of the most extensively studied molecular chaperones. So far, ~80 proteins in E. coli are identified as GroE substrates that obligately require GroE for folding in vivo. In GroE-depleted cells, these
Tatsuya Niwa +2 more
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IUBMB Life, 2009 AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
openaire +4 more sources
Turkish Journal of Agriculture: Food Science and Technology, 2020 In this study, effects of medium components and inoculum size on the protease production by Bacillus sp. EBTA6 that was isolated from a home-made Tarhana sample were investigated. The cell-free supernatant of bacterium cultured on a shaking incubator for
Fikriye Alev Akçay, Ayşe Avcı
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EFFECT OF DIFFERENT LEVELS AGROECOLOGICAL LOADS ON BIOCHEMICAL CHARACTERISTICS OF SOIL
Юг России: экология, развитие, 2017 Aim. To study the effect of different levels of agri-environmental loads on the enzymatic activity of the soil.Methods. Isolation of soil fauna was conducted by thermogradient.
A. V. Shchur +2 more
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