Results 11 to 20 of about 1,749,266 (388)
Cell Reports Medicine, 2021 Summary: Severe SARS-CoV-2 infection often leads to the development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is not clear whether ARDS from SARS-CoV-2 is similar to that observed in
Camilla Margaroli +10 more
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The endothelial glycocalyx in critical illness: A pediatric perspective
Matrix Biology Plus, 2022 The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function through ...
Robert P. Richter +4 more
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Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis
Frontiers in Medicine, 2023 ObjectivesOur objective was to examine coronary endothelial and myocardial programming in patients with severe COVID-19 utilizing digital spatial transcriptomics.BackgroundSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has well-established ...
Camilla Margaroli +37 more
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Diet, microbiota, and the mucus layer: The guardians of our health
Frontiers in Immunology, 2022 The intestinal tract is an ecosystem in which the resident microbiota lives in symbiosis with its host. This symbiotic relationship is key to maintaining overall health, with dietary habits of the host representing one of the main external factors ...
Francesco Suriano +3 more
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Current Protocols in Protein Science, 2000 AbstractThe processes of growth and remodeling of cells and tissues in multicellular organisms require the breakdown of old protein molecules, in concert with the synthesis of new ones. For example, many newly‐synthesized molecules require proteolytic processing to convert them to biologically active forms.
Harris, Jennifer L., Craik, Charles S.
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Science, 2020 Targeting a key enzyme in SARS-CoV-2 Scientists across the world are working to understand severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). Zhang et al.
Linlin Zhang +8 more
semanticscholar +1 more source
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Science, 2020 Promising antiviral protease inhibitors With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments.
Wenhao Dai +26 more
semanticscholar +1 more source
Individual or combinational use of phytase, protease, and xylanase for the impacts on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble fed to pigs [PDF]
Animal Bioscience, 2023 Objective This study was to evaluate the effects of individual or combinational use of phytase, protease, and xylanase on total tract digestibility of corn, soybean meal, and distillers dried grains with soluble (DDGS) fed to pigs.
Adsos Adami Passos +2 more
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Nature Communications, 2021 COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close human analogs.
B. Boras +51 more
semanticscholar +1 more source
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
Nature, 2020 The papain-like protease PLpro is an essential coronavirus enzyme that is required for processing viral polyproteins to generate a functional replicase complex and enable viral spread 1 , 2 .
Donghyuk Shin +21 more
semanticscholar +1 more source