Results 11 to 20 of about 1,598,143 (384)
Current Protocols in Protein Science, 2000 AbstractThe processes of growth and remodeling of cells and tissues in multicellular organisms require the breakdown of old protein molecules, in concert with the synthesis of new ones. For example, many newly‐synthesized molecules require proteolytic processing to convert them to biologically active forms.
Jennifer L. Harris, Charles S. Craik
openaire +5 more sources
Gastric Proteases and Protease Inhibitors
Gastroenterology, 1967 Michael D. Turner +2 more
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Protease inhibitors targeting the main protease and papain-like protease of coronaviruses [PDF]
Expert Opinion on Therapeutic Patents, 2020 The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and the papain-like protease (PLP) are conserved among the three pathogens and started to be considered as exciting drug targets for developing antivirals.We review the drug design landscape in the
Capasso, Clemente +2 more
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Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity
Nature, 2020 The papain-like protease PLpro is an essential coronavirus enzyme that is required for processing viral polyproteins to generate a functional replicase complex and enable viral spread 1 , 2 .
Donghyuk Shin +21 more
semanticscholar +1 more source
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors
Nature Communications, 2020 The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases potentially targetable with antivirals.
J. Osipiuk +20 more
semanticscholar +1 more source
Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
Nature Communications, 2020 The main protease, Mpro (or 3CLpro) in SARS-CoV-2 is a viable drug target because of its essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal coronavirus infection in cats, was successfully treated previously ...
Wayne Vuong +13 more
semanticscholar +1 more source
In silico prediction of mutant HIV-1 proteases cleaving a target sequence [PDF]
, 2014 HIV-1 protease represents an appealing system for directed enzyme re-design, since it has various different endogenous targets, a relatively simple structure and it is well studied.
De Vico, Luca +3 more
core +6 more sources
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease
Nature Communications, 2020 COVID-19 was declared a pandemic on March 11 by WHO, due to its great threat to global public health. The coronavirus main protease (Mpro, also called 3CLpro) is essential for processing and maturation of the viral polyprotein, therefore recognized as an
L. Fu +15 more
semanticscholar +1 more source
Docking study on anti-HIV-1 activity of secondary metabolites from Zingiberaceae plants
Journal of Pharmacy and Bioallied Sciences, 2020 Introduction: Human immunodeficiency virus type-1 (HIV-1) that causes acquired immunodeficiency syndrome (AIDS) has become a worldwide health problem today. There are approximately 30 anti-HIV-1 drugs that have been used in the treatment of AIDS. However,
Muhammad Sulaiman Zubair +4 more
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