Results 181 to 190 of about 3,932,956 (396)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Multicenter Quality Control of Hepatitis C Virus Protease Inhibitor Resistance Genotyping [PDF]

, 2013
Sophie Vallet, Sylvie Larrat, Syria Laperche, Hélène Le Guillou‐Guillemette, Florence Abravanel, Françoise Bouchardeau, Adeline Pivert, Cécile Henquell, Audrey Mirand, Elisabeth André‐Garnier, Valérie Giordanengo, Gisèle Lagathu, Vincent Thibault, Caroline Scholtès, Évelyne Schvoerer, Catherine Gaudy‐Graffin, Sarah Maylin, Pascale Trimoulet, Étienne Brochot, Sébastien Hantz, Joël Gozlan, Anne‐Marie Roque‐Afonso, Patrick Soussan, Jean‐Christophe Plantier, Charlotte Charpentier, Stéphane Chevaliez, Philippe Colson, Vincent Mackiewicz, Lina Aguilera Munoz, S. Rosec, S. Gouriou, Nelly Magnat, Françoise Lunel‐Fabiani, Jacques Izopet, Patrice Morand, Christopher Payan, Jean–Michel Pawlotsky   +36 more
openalex   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

FEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

RETRACTED: A novel mechanism of a protease inhibitor protein, Xbpi-1, against Acyrthosiphon pisum [PDF]

Tingting Zhang, Qiannan Li, Xiaokang Li, Fukang Bu, Yinchen Yu, Meng Liu, Tonghao Li, Zheng Li, Jianjun Mao, Fanrong Zeng   +9 more
openalex   +1 more source

How an Inhibitor of the HIV-I Protease Modulates Proteasome Activity [PDF]

, 1999
Gunter Schmidtke, Hermann−Georg Holzhütter, Matthew Bogyo, Norman Kairies, M. Groll, Rita de Giuli, Sabine Emch, Marcus Groettrup   +7 more
openalex   +1 more source

Repurposing Peptidomimetic Drugs as Potential Inhibitors of Novel SARS-CoV-2 Main Protease Using Network Theory: A Protein-Ligand Binding Site Similarity Approach [PDF]

, 2022
Sagar S. Bhayye, N. Sukumar
openalex   +1 more source

Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur

Nature Structural & Molecular Biology, 2020
Zhenming Jin, Yao Zhao, Yuanyuan Sun, Bing Zhang, Haofeng Wang, Yan Wu, Yan Zhu, Chen Zhu, T. Hu, Xiaoyu Du, Yinkai Duan, Jing Yu, Xiaobao Yang, Xiuna Yang, Kailin Yang, Xiang Liu, L. Guddat, Gengfu Xiao, Lei-ke Zhang, Haitao Yang, Z. Rao   +20 more
semanticscholar   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source