Results 21 to 30 of about 645,171 (161)

Defining the Protease and Protease Inhibitor (P/PI) Proteomes of Healthy and Diseased Human Skin by Modified Systematic Review

Biomolecules, 2022
Proteases and protease inhibitors (P/PIs) are involved in many biological processes in human skin, yet often only specific families or related groups of P/PIs are investigated.
Callum Stewart-McGuinness, Christopher I. Platt, Matiss Ozols, Brian Goh, Tamara W. Griffiths, Michael J. Sherratt   +5 more
doaj   +1 more source

Realtime, continuous assessment of complex-mixture protease and protease inhibitor activity

4 open, 2022
Recently the treatment PAXLOVID™ (nirmatrelvir co-packaged with ritonavir) was authorized for use as a treatment for COVID-19. The presumed mechanism of action of the treatment, an inhibitor of a Sars-Cov-2 “3CL” protease, continues decades-long interest
Leonard Sarah-Ellen, Kenis Paul J.A., Perkins Ray C.   +2 more
doaj   +1 more source

Sulfur mustard-stimulated proteases and their inhibitors in a cultured normal human epidermal keratinocytes model: A potential approach for anti-vesicant drug development

Toxicology Reports, 2016
Protease stimulation in cultured normal human epidermal keratinocytes (NHEK) due to sulfur mustard (SM) exposure is well documented. However, the specific protease(s) stimulated by SM and the protease substrates remain to be determined. In this study, we
Xiannu Jin, Radharaman Ray, Prabhati Ray
doaj   +1 more source

Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin

Toxins, 2021
Iota-toxin from Clostridium perfringens type E is a binary toxin composed of two independent proteins: actin-ADP-ribosylating enzyme component, iota-a (Ia), and binding component, iota-b (Ib).
Masahiro Nagahama, Keiko Kobayashi, Masaya Takehara   +2 more
doaj   +1 more source

Inhibitor‐assisted refolding of protease: A protease inhibitor as an intramolecular chaperone [PDF]

FEBS Letters, 2005
Pleurotus ostrearus proteinase A inhibitor 1 (POIA1), which was discovered as a protease inhibitor, is unique in that it shows sequence homology to the propeptide of subtilisin, which functions as an intramolecular of a cognate protease. In this study, we demonstrate that POIA1 can function as an intramolecular chaperone of subtilisin by in vitro and ...
Kojima, Shuichi, Iwahara, Akane, Yanai, Hideyuki   +2 more
openaire   +2 more sources

Role of Protease-Inhibitors in Ocular Diseases

Molecules, 2014
It has been demonstrated that the balance between proteases and protease-inhibitors system plays a key role in maintaining cellular and tissue homeostasis. Indeed, its alteration has been involved in many ocular and systemic diseases.
Nicola Pescosolido, Andrea Barbato, Antonia Pascarella, Rossella Giannotti, Martina Genzano, Marcella Nebbioso   +5 more
doaj   +1 more source

Commentary on the role of treatment-related HIV compensatory mutations on increasing virulence: new discoveries twenty years since the clinical testing of protease inhibitors to block HIV-1 replication

BMC Medicine, 2012
Approximately 20 years has passed since the first human trial with HIV-1 protease inhibitors. Protease inhibitors set the stage for combination therapy in the mid-1990s but are now rarely used in first-line combination therapy and reserved for salvage ...
Arts Eric J
doaj   +1 more source

A Multifunctional Trypsin Protease Inhibitor from Yellow Bell Pepper Seeds: Uncovering Its Dual Antifungal and Hypoglycemic Properties

Pharmaceutics, 2023
Fungal infections are a growing public health concern worldwide and the emergence of antifungal resistance has limited the number of therapeutic options. Therefore, developing novel strategies for identifying and developing new antifungal compounds is an
Juliana Cotabarren, Brenda Ozón, Santiago Claver, Florencia Geier, Martina Rossotti, Javier Garcia-Pardo, Walter David Obregón   +6 more
doaj   +1 more source

PEMURNIAN DAN KARAKTERISASI INHIBITOR PROTEASE DARI Chromohalobacter sp. 6A3, BAKTERI YANG BERASOSIASI DENGAN SPONS Xetospongia testudinaria [Purification and Characterization of Protease Inhibitor from Chromohalobacter sp. 6A3, Bacteria-associated with Sponge Xetospongia testudinaria]

Jurnal Teknologi dan Industri Pangan, 2010
Various sponges has been reported to produce protease inhibitor which could inhibit protease activity of pathogenic bacteria. The previous research showed that bacteria-associated with sponge could produce bioactive compound similar to their host ...
Tati Nurhayati1)*, Maggy T. Suhartono2), Lilis Nuraida2), Sri Budiarti Poerwanto3)   +3 more
doaj  

A cysteine protease inhibitor GC376 displays potent antiviral activity against coxsackievirus infection

Current Research in Microbial Sciences, 2023
Infection with coxsackievirus A10 (CV-A10) can cause hand-foot-mouth disease and is also associated with severe complications, including viral pneumonia, aseptic and viral meningitis.
Yongkang Chen, Xiaohong Li, Min Wang, Yuan Li, Jun Fan, Jingjing Yan, Shuye Zhang, Lu Lu, Peng Zou   +8 more
doaj   +1 more source