Results 21 to 30 of about 638,874 (218)

High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania - A prospective cohort study.

PLoS ONE, 2020
BACKGROUND:Poor adherence to antiretroviral drugs and viral resistance are the main drivers of treatment failure in HIV-infected patients. In sub-Saharan Africa, avoidance of treatment failure on second-line protease inhibitor therapy is critical as ...
Rahel E Bircher, Alex J Ntamatungiro, Tracy R Glass, Dorcas Mnzava, Amina Nyuri, Herry Mapesi, Daniel H Paris, Manuel Battegay, Thomas Klimkait, Maja Weisser, KIULARCO study group   +10 more
doaj   +1 more source

A spider-derived Kunitz-type serine protease inhibitor that acts as a plasmin inhibitor and an elastase inhibitor. [PDF]

PLoS ONE, 2013
Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and inflammation.
Hu Wan, Kwang Sik Lee, Bo Yeon Kim, Feng Ming Zou, Hyung Joo Yoon, Yeon Ho Je, Jianhong Li, Byung Rae Jin   +7 more
doaj   +1 more source

Differences in the Inhibitory Specificity Distinguish the Efficacy of Plant Protease Inhibitors on Mouse Fibrosarcoma

Plants, 2021
Metastasis, the primary cause of death from malignant tumors, is facilitated by multiple protease-mediated processes. Thus, effort has been invested in the development of protease inhibitors to prevent metastasis.
Sonia Yoo Im, Camila Ramalho Bonturi, Adriana Miti Nakahata, Clóvis Ryuichi Nakaie, Arnildo Pott, Vali Joana Pott, Maria Luiza Vilela Oliva   +6 more
doaj   +1 more source

The Effects of Side-Chain Configurations of a Retro–Inverso-Type Inhibitor on the Human T-Cell Leukemia Virus (HTLV)-1 Protease

Molecules, 2022
In this study, the effects of side-chain configurations of D-Ile residues of a retro–inverso (RI)-type inhibitor on the human T-cell leukemia virus type 1 (HTLV-1) protease containing a hydroxyethylamine dipeptide isostere were clarified.
Chiyuki Awahara, Daiki Oku, Saki Furuta, Kazuya Kobayashi, Kenta Teruya, Kenichi Akaji, Yasunao Hattori   +6 more
doaj   +1 more source

Factors Associated with the Development of Drug Resistance Mutations in HIV-1 Infected Children Failing Protease Inhibitor-Based Antiretroviral Therapy in South Africa.

PLoS ONE, 2015
ObjectiveLimited data are available from the developing world on antiretroviral drug resistance in HIV-1 infected children failing protease inhibitor-based antiretroviral therapy, especially in the context of a high tuberculosis burden.
Theresa M Rossouw, Ute D Feucht, George Melikian, Gisela van Dyk, Winifred Thomas, Nicolette M du Plessis, Theunis Avenant   +6 more
doaj   +1 more source

Proteinaceous Protease Inhibitor from : Purification, Characterization and Antibacterial Activity

Natural Product Communications, 2013
A thermo-stable, proteinaceous protease inhibitor (LPI) from Lawsonia inermis is reported. The LPI was purified from Lawsonia inermis seeds by subsequent ammonium sulfate precipitation, ion exchange chromatography (DEAE-Cellulose) and gel permeation ...
Arvind Dabhade, Priti Patel, Ulhas Patil
doaj   +1 more source

Studi molecular docking senyawa 1,5-benzothiazepine sebagai inhibitor dengue DEN-2 NS2B/NS3 serine protease

Chempublish Journal, 2021
Studi molecular docking senyawa 1,5-benzothiazepine turunan kalkon dengan protein target dari permodelan struktur kristalografi Protease dengan kode 2FOM dilakukan dengan komputer menggunakan program Molecular Operating Environment (MOE). Penelitian ini
Neni Frimayanti, Anita Lukman, Livia Nathania   +2 more
doaj   +1 more source

Spatiotemporal expression and regulation of peptidase inhibitor 3 and secretory leukocyte protease inhibitor at the maternal–fetal interface in pigs [PDF]

Animal Bioscience, 2023
Objective Two serine protease inhibitors, peptidase inhibitor 3 (PI3) and secretory leukocyte protease inhibitor (SLPI), play important roles in protease inhibition and antimicrobial activity, but their expression, regulation, and function at the ...
Soohyung Lee, Inkyu Yoo, Yugyeong Cheon, Hakhyun Ka   +3 more
doaj   +1 more source

Defining the Protease and Protease Inhibitor (P/PI) Proteomes of Healthy and Diseased Human Skin by Modified Systematic Review

Biomolecules, 2022
Proteases and protease inhibitors (P/PIs) are involved in many biological processes in human skin, yet often only specific families or related groups of P/PIs are investigated.
Callum Stewart-McGuinness, Christopher I. Platt, Matiss Ozols, Brian Goh, Tamara W. Griffiths, Michael J. Sherratt   +5 more
doaj   +1 more source

Realtime, continuous assessment of complex-mixture protease and protease inhibitor activity

4 open, 2022
Recently the treatment PAXLOVID™ (nirmatrelvir co-packaged with ritonavir) was authorized for use as a treatment for COVID-19. The presumed mechanism of action of the treatment, an inhibitor of a Sars-Cov-2 “3CL” protease, continues decades-long interest
Leonard Sarah-Ellen, Kenis Paul J.A., Perkins Ray C.   +2 more
doaj   +1 more source