Results 21 to 30 of about 1,452,849 (304)

A spider-derived Kunitz-type serine protease inhibitor that acts as a plasmin inhibitor and an elastase inhibitor. [PDF]

PLoS ONE, 2013
Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and inflammation.
Hu Wan, Kwang Sik Lee, Bo Yeon Kim, Feng Ming Zou, Hyung Joo Yoon, Yeon Ho Je, Jianhong Li, Byung Rae Jin   +7 more
doaj   +1 more source

Lipopeptides as dimerization inhibitors of HIV-1 protease [PDF]

, 1999
In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g, HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs, An alternative ...
Schramm, W., Schramm, H. J., Büttner, J., de Rosny, E., Dick, A., Reboud-Ravaux, M.   +5 more
core   +1 more source

Differences in the Inhibitory Specificity Distinguish the Efficacy of Plant Protease Inhibitors on Mouse Fibrosarcoma

Plants, 2021
Metastasis, the primary cause of death from malignant tumors, is facilitated by multiple protease-mediated processes. Thus, effort has been invested in the development of protease inhibitors to prevent metastasis.
Sonia Yoo Im, Camila Ramalho Bonturi, Adriana Miti Nakahata, Clóvis Ryuichi Nakaie, Arnildo Pott, Vali Joana Pott, Maria Luiza Vilela Oliva   +6 more
doaj   +1 more source

Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting. [PDF]

, 2011
In resource-limited settings, many patients, with no prior protease inhibitor (PI) treatment on a second-line, high genetic barrier, ritonavir-boosted PI-containing regimen have virologic ...
Monica Gandhi, Yong Huang, McIlleron, Helen, Huang, Yong, Nachega, Jean B, van Mens, Thijs E, Malavazzi, Carolina, Thijs E van Mens, Helen McIlleron, Gert Uves van Zyl, Peter Smith, Eric Decloedt, Maartens, Gary, Gary Maartens, Decloedt, Eric, Gandhi, Monica, van Zyl, Gert Uves, Smith, Peter, Zeier, Michele, Lize van der Merwe, Michele Zeier, Carolina Malavazzi, Jean B Nachega, van der Merwe, Lize   +23 more
core   +1 more source

The Effects of Side-Chain Configurations of a Retro–Inverso-Type Inhibitor on the Human T-Cell Leukemia Virus (HTLV)-1 Protease

Molecules, 2022
In this study, the effects of side-chain configurations of D-Ile residues of a retro–inverso (RI)-type inhibitor on the human T-cell leukemia virus type 1 (HTLV-1) protease containing a hydroxyethylamine dipeptide isostere were clarified.
Chiyuki Awahara, Daiki Oku, Saki Furuta, Kazuya Kobayashi, Kenta Teruya, Kenichi Akaji, Yasunao Hattori   +6 more
doaj   +1 more source

The role of the HIV-1 protease substrate in therapy resistance [PDF]

, 2015
In Switzerland and Germany up to a half of the first-line regimens include protease inhibitors (PIs) [1, 2]. Although in the Swiss HIV Cohort Study (SHCS) most patients under antiretroviral therapy (ART) have suppressed viral loads [3], every third ...
Kletenkov, Konstantin
core   +1 more source

Repurposed Single Inhibitor for Serine Protease and Spike Glycoproteins of SAR-CoV-2 [PDF]

, 2020
In this research, structure of SARS-CoV-2 spike glycoprotein S1 and S2 along with TMPRSS2, TMPRSS4, TMPRSS11A, TMPRSS11D and TMPRSS11E serine protease (which activates S1 and S2) are used for docking with repurposed inhibitor drug molecules.
Mohtasheemul, Hassan, Tanzila, Arshad, Hamdullah, Khadim Sheikh, Iqra, Arshad, Zainab Sher, Mohammad   +4 more
core   +1 more source

Factors Associated with the Development of Drug Resistance Mutations in HIV-1 Infected Children Failing Protease Inhibitor-Based Antiretroviral Therapy in South Africa.

PLoS ONE, 2015
ObjectiveLimited data are available from the developing world on antiretroviral drug resistance in HIV-1 infected children failing protease inhibitor-based antiretroviral therapy, especially in the context of a high tuberculosis burden.
Theresa M Rossouw, Ute D Feucht, George Melikian, Gisela van Dyk, Winifred Thomas, Nicolette M du Plessis, Theunis Avenant   +6 more
doaj   +1 more source

Proteinaceous Protease Inhibitor from : Purification, Characterization and Antibacterial Activity

Natural Product Communications, 2013
A thermo-stable, proteinaceous protease inhibitor (LPI) from Lawsonia inermis is reported. The LPI was purified from Lawsonia inermis seeds by subsequent ammonium sulfate precipitation, ion exchange chromatography (DEAE-Cellulose) and gel permeation ...
Arvind Dabhade, Priti Patel, Ulhas Patil
doaj   +1 more source

Studi molecular docking senyawa 1,5-benzothiazepine sebagai inhibitor dengue DEN-2 NS2B/NS3 serine protease

Chempublish Journal, 2021
Studi molecular docking senyawa 1,5-benzothiazepine turunan kalkon dengan protein target dari permodelan struktur kristalografi Protease dengan kode 2FOM dilakukan dengan komputer menggunakan program Molecular Operating Environment (MOE). Penelitian ini
Neni Frimayanti, Anita Lukman, Livia Nathania   +2 more
doaj   +1 more source