Results 31 to 40 of about 645,171 (161)

PEMURNIAN DAN KARAKTERISASI INHIBITOR PROTEASE DARI Chromohalobacter sp. 6A3, BAKTERI YANG BERASOSIASI DENGAN SPONS Xetospongia testudinaria [Purification and Characterization of Protease Inhibitor from Chromohalobacter sp. 6A3, Bacteria-associated with S

Jurnal Teknologi dan Industri Pangan, 2010
  Various sponges has been reported to produce protease inhibitor which could inhibit protease activity of pathogenic bacteria. The previous research showed that bacteria-associated with sponge could produce bioactive compound similar to their host ...
Tati Nurhayati, Maggy T. Suhartono, Lilis Nuraida, Sri Budiarti Poerwanto   +3 more
doaj  

Reverse Zymmogram Analysis for the Detection of Protease Inhibitor Activity

Bio-Protocol, 2013
This protocol describes a gel-based procedure to detect protease inhibitor activity. In this method gelatin is used as a substrate for proteolysis and is copolymerized within the polyacrylamide matrix. Protein extracts are fractioned by SDS-PAGE and then
Lilia Bernal, Florencia García-Campusano, Edgar Nájera, Felipe Cruz-García   +3 more
doaj   +1 more source

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif.

PLoS ONE, 2019
Engagement of an extended β-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski mechanism inhibitors that present a substrate-like loop to a target protease.
Xingchen Chen, Blake T Riley, Simon J de Veer, David E Hoke, Jessica Van Haeften, Darren Leahy, Joakim E Swedberg, Maria Brattsand, Perry J Hartfield, Ashley M Buckle, Jonathan M Harris   +10 more
doaj   +1 more source

Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation.

PLoS ONE, 2016
Significant proteolysis may occur during milk synthesis and secretion, as evidenced by the presence of protease-protease inhibitor complex containing the activated form of the type 2 transmembrane serine protease matriptase and the transmembrane Kunitz ...
Chih-Hsin Lai, Ying-Jung J Lai, Feng-Pai Chou, Hsiang-Hua D Chang, Chun-Che Tseng, Michael D Johnson, Jehng-Kang Wang, Chen-Yong Lin   +7 more
doaj   +1 more source

Assay for Protealysin-like Protease Inhibitor Activity

Bio-Protocol, 2022
Here, we present the first quantitative method for the activity analysis of protealysin-like protease (PLP) inhibitors. This approach is based on a previously developed method for protealysin activity determination by hydrolysis of internally quenched ...
Igor Berdyshev, Maria Karaseva, Ilya Demidyuk   +2 more
doaj   +1 more source

Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection

Virology Journal, 2017
Background Host proteases have been shown to play important roles in many viral activities such as entry, uncoating, viral protein production and disease induction.
Winke Van der Gucht, Annelies Leemans, Marjorie De Schryver, Annick Heykers, Guy Caljon, Louis Maes, Paul Cos, Peter L. Delputte   +7 more
doaj   +1 more source

Three cryo-EM structures of CD109 reveal its mechanism of protease inhibition

Cell Reports
Summary: CD109 is a glycosylphosphatidylinositol-anchored protein. In addition to regulating transforming growth factor β (TGF-β) network signaling, CD109 is also a protease inhibitor. Protease cleavage of its bait region triggers a conformational change
Ana V. Almeida, Kathrine T. Jensen, Seandean L. Harwood, Martin H. Jørgensen, Nadia S. Nielsen, Ida B. Thøgersen, Jan J. Enghild, Gregers R. Andersen   +7 more
doaj   +1 more source

Preliminary Characterization of Protease Inhibitor from Bacteria Associated with Sponge from Panggang Island, Seribu Islands

Hayati Journal of Biosciences, 2006
Pathogenic bacteria produced protease that involved in molecular mechanism of foodborne disease. Produced protease involved in molecular mechanisms of foodborne diseases. The purpose of this research was to screen, identify and characterize the potential
TATI NURHAYATI, MAGGY THENAWIDJAJA SUHARTONO, LILIS NURAIDA, SRI BUDIARTI POERWANTO   +3 more
doaj  

Non-active site mutants of HIV-1 protease influence resistance and sensitisation towards protease inhibitors

Retrovirology, 2020
Background HIV-1 can develop resistance to antiretroviral drugs, mainly through mutations within the target regions of the drugs. In HIV-1 protease, a majority of resistance-associated mutations that develop in response to therapy with protease ...
Tomas Bastys, Vytautas Gapsys, Hauke Walter, Eva Heger, Nadezhda T. Doncheva, Rolf Kaiser, Bert L. de Groot, Olga V. Kalinina   +7 more
doaj   +1 more source

Diversity of cultivable protease-producing bacteria in sediments of Jiaozhou Bay, China

Frontiers in Microbiology, 2015
Although protease-producing bacteria are key players in the degradation of organic nitrogen and essential for the nitrogen recycling in marine sediments, diversity of both these bacteria and their extracellular proteases is still largely unknown.
Xi-Ying eZhang, Xiao-Xu eHan, Xiu-Lan eChen, Hong-Yue eDang, Bin-Bin eXie, Qi-Long eQin, Mei eShi, Bai-Cheng eZhou, Yu-Zhong eZhang   +8 more
doaj   +1 more source