Results 31 to 40 of about 1,452,849 (304)

Binding and Reactivity of a Nitrile Oral Inhibitor of SARS-CoV-2 Main Protease Revealed by Computational Simulations [PDF]

, 2021
We present a detailed analysis of the binding mode and reactivity of the novel oral inhibitor PF-07321332 developed against SARS-CoV-2 3CL protease. Classical and QM/MM Molecular Dynamics simulations are used to quantify the contributions to the binding ...
Iñaki, Tuñón, Carlos A., Ramos-Guzmán, Jose Javier, Ruiz-Pernía   +2 more
core   +1 more source

Defining the Protease and Protease Inhibitor (P/PI) Proteomes of Healthy and Diseased Human Skin by Modified Systematic Review

Biomolecules, 2022
Proteases and protease inhibitors (P/PIs) are involved in many biological processes in human skin, yet often only specific families or related groups of P/PIs are investigated.
Callum Stewart-McGuinness, Christopher I. Platt, Matiss Ozols, Brian Goh, Tamara W. Griffiths, Michael J. Sherratt   +5 more
doaj   +1 more source

Evidence for reduced drug susceptibility without emergence of major protease mutations following protease inhibitor monotherapy failure in the SARA trial [PDF]

, 2015
Background: Major protease mutations are rarely observed following failure with protease inhibitors (PI), and other viral determinants of failure to PI are poorly understood.
Kapaata, Anne, Spyer, M., Charles F. Gilks (164480), Pontiano Kaleebu (62293), Lyagoba, F., Chris M Parry, Anne Kapaata, Gupta, R.K., Pillay, Deenan, DART Virology Group, Parry, Chris M., Lyagoba, Fred, McCormick, A.L., Gilks, Charles F, Kityo Cissy, Kaleebu, Pontiano, Gupta, Ravindra K., Cissy Kityo, Sutherland, Katherine A, McCormick, Adele, Katherine A. Sutherland (797812), Fred Lyagoba (769668), Gilks Charles F., Ruth Goodall, Katherine A Sutherland, Kapaata Anne, Ruth Goodall (225826), Gupta, Ravindra K, Charles F Gilks, Spyer Moira, Spyer, Moira, Ravindra K. Gupta (372679), Goodall Ruth, Kityo, Cissy, Adele McCormick, McCormick Adele, Cissy Kityo (168842), Goodall, R., Parry Chris M., Fred Lyagoba, Pillay, D., Kaleebu Pontiano, Sutherland Katherine A., Parry, Chris M, Adele McCormick (797813), Gilks, C.F., Pillay Deenan, Gupta Ravindra K., Deenan Pillay (7888), Moira Spyer (164453), Sutherland, Katherine A., Parry, C.M., Sutherland, K.A., Pontiano Kaleebu, Kaleebu, P., Moira Spyer, Goodall, Ruth, Chris M. Parry (304425), Kityo, C., Lyagoba Fred, Ravindra K Gupta, Gilks, Charles F., Kapaata, A., Anne Kapaata (797814), Deenan Pillay   +64 more
core   +2 more sources

Realtime, continuous assessment of complex-mixture protease and protease inhibitor activity

4 open, 2022
Recently the treatment PAXLOVID™ (nirmatrelvir co-packaged with ritonavir) was authorized for use as a treatment for COVID-19. The presumed mechanism of action of the treatment, an inhibitor of a Sars-Cov-2 “3CL” protease, continues decades-long interest
Leonard Sarah-Ellen, Kenis Paul J.A., Perkins Ray C.   +2 more
doaj   +1 more source

Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin

Toxins, 2021
Iota-toxin from Clostridium perfringens type E is a binary toxin composed of two independent proteins: actin-ADP-ribosylating enzyme component, iota-a (Ia), and binding component, iota-b (Ib).
Masahiro Nagahama, Keiko Kobayashi, Masaya Takehara   +2 more
doaj   +1 more source

Inhibitor‐assisted refolding of protease: A protease inhibitor as an intramolecular chaperone [PDF]

FEBS Letters, 2005
Pleurotus ostrearus proteinase A inhibitor 1 (POIA1), which was discovered as a protease inhibitor, is unique in that it shows sequence homology to the propeptide of subtilisin, which functions as an intramolecular of a cognate protease. In this study, we demonstrate that POIA1 can function as an intramolecular chaperone of subtilisin by in vitro and ...
Kojima, Shuichi, Iwahara, Akane, Yanai, Hideyuki   +2 more
openaire   +2 more sources

Sulfur mustard-stimulated proteases and their inhibitors in a cultured normal human epidermal keratinocytes model: A potential approach for anti-vesicant drug development

Toxicology Reports, 2016
Protease stimulation in cultured normal human epidermal keratinocytes (NHEK) due to sulfur mustard (SM) exposure is well documented. However, the specific protease(s) stimulated by SM and the protease substrates remain to be determined. In this study, we
Xiannu Jin, Radharaman Ray, Prabhati Ray
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Role of Protease-Inhibitors in Ocular Diseases

Molecules, 2014
It has been demonstrated that the balance between proteases and protease-inhibitors system plays a key role in maintaining cellular and tissue homeostasis. Indeed, its alteration has been involved in many ocular and systemic diseases.
Nicola Pescosolido, Andrea Barbato, Antonia Pascarella, Rossella Giannotti, Martina Genzano, Marcella Nebbioso   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source