NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile virus NS2B-NS3 protease. [PDF]
PLoS Neglected Tropical Diseases, 2009 BACKGROUND: The two-component NS2B-NS3 proteases of West Nile and dengue viruses are essential for viral replication and established targets for drug development.
Xun-Cheng Su +5 more
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Small Molecule Protease Inhibitors as Model Peptidomimetics [PDF]
PharmaceuticalsProteases constitute one of the largest sub-classes of enzymes, accounting for ca. 2% of the proteins encoded in the human genome. They play a key role in protein degradation and signaling, regulating a variety of physiological processes.
Patricia Gomez-Gutierrez, Juan J. Perez
doaj +2 more sources
Developing HIV-1 Protease Inhibitors through Stereospecific Reactions in Protein Crystals [PDF]
Molecules, 2016 Protease inhibitors are key components in the chemotherapy of HIV infection. However, the appearance of viral mutants routinely compromises their clinical efficacy, creating a constant need for new and more potent inhibitors.
Folasade M. Olajuyigbe +3 more
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Susceptibility of HPV-18 Cancer Cells to HIV Protease Inhibitors [PDF]
VirusesCervical cancer cases continue to rise despite all the advanced screening and preventative measures put in place, which include human papillomavirus (HPV) vaccination.
Lilian Makgoo +2 more
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Optimized pipeline and designer cells for synthetic-biology-based high-throughput screening of viral protease inhibitors [PDF]
Cell Reports: MethodsSummary: A reliable, efficient, high-throughput pipeline to evaluate viral protease inhibitors would enhance antiviral drug discovery. Methods such as crystallography and phenotypic screening are often constrained by complex assay conditions, limited ...
Shlomi Edri +10 more
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Efficacy and safety of 3CL protease inhibitors in patients with mild or moderate COVID-19: a systematic review and meta-analysis of randomized controlled trials [PDF]
Virology JournalBackground Remdesivir has been established as a safe treatment for patients with COVID-19. However, given the SARS-CoV-2 random mutations, 3CL protease inhibitors have been studied in recent randomized controlled trials.
Nicole Jean Lee +6 more
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PLoS ONE, 2022 The HTLV-1 protease is one of the major antiviral targets to overwhelm this virus. Several research groups have developed protease inhibitors, but none has been successful.
Fereshteh Noroozi Tiyoula +2 more
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HIV Protease: Historical Perspective and Current Research
Viruses, 2021 The retroviral protease of human immunodeficiency virus (HIV) is an excellent target for antiviral inhibitors for treating HIV/AIDS. Despite the efficacy of therapy, current efforts to control the disease are undermined by the growing threat posed by ...
Irene T. Weber +2 more
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Fractional-order susceptible-infected model: definition and applications to the study of COVID-19 main protease [PDF]
, 2020 We propose a model for the transmission of perturbations across the amino acids of a protein represented as an interaction network. The dynamics consists of a Susceptible-Infected (SI) model based on the Caputo fractional-order derivative.
Abadias, Luciano +2 more
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Triple Therapy with First Generation Protease Inhibitors for Hepatitis C Markedly Impairs Function of Neutrophil Granulocytes. [PDF]
PLoS ONE, 2016 First-generation HCV protease inhibitors represent a milestone in antiviral therapy for chronic hepatitis C infection (CHC), but substantially increased rates of viral clearance are offset by increased rates of infection and infection-associated deaths ...
Walter Spindelboeck +14 more
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