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Inhibitor‐assisted refolding of protease: A protease inhibitor as an intramolecular chaperone [PDF]
FEBS Letters, 2005 Pleurotus ostrearus proteinase A inhibitor 1 (POIA1), which was discovered as a protease inhibitor, is unique in that it shows sequence homology to the propeptide of subtilisin, which functions as an intramolecular of a cognate protease. In this study, we demonstrate that POIA1 can function as an intramolecular chaperone of subtilisin by in vitro and ...
Akane Iwahara +2 more
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Preliminary investigations on the serine and aspartic protease inhibitors from Nothopegia beddomei
Ceylon Journal of Science, 2019 Aqueous stem bark extract of Nothopegia beddomei was assayed for serine and aspartic protease inhibitors by using trypsin and pepsin as the target enzymes, respectively. Crude bark extract was dialyzed and subjected to inhibition assays.
M.G.K.P. Dayarathne, Sanath Rajapakse
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Plant Serine Protease Inhibitors: Biotechnology Application in Agriculture and Molecular Farming
International Journal of Molecular Sciences, 2019 The serine protease inhibitors (SPIs) are widely distributed in living organisms like bacteria, fungi, plants, and humans. The main function of SPIs as protease enzymes is to regulate the proteolytic activity.
Marina Clemente +5 more
semanticscholar +1 more source
The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
MedComm, 2022 The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has demonstrated that 3CLpros play an indispensable role in viral replication and ...
Qing Hu +6 more
semanticscholar +1 more source
Detecção de inibidores de proteases em sementes de Punica granatum
Química NovaThe use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation.
Lara Franca Colares +6 more
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Frontiers in Physiology, 2019 Plutella xylostella L. (diamondback moth) is a pest of cruciferous plants. To understand the relationship among protease inhibitors, protease activities and the growth and development of this insect, the activities of midgut proteases of P.
Aiping Zhao +8 more
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Structure and Dynamics of Zika Virus Protease and Its Insights into Inhibitor Design
Biomedicines, 2021 Zika virus (ZIKV)—a member of the Flaviviridae family—is an important human pathogen. Its genome encodes a polyprotein that can be further processed into structural and non-structural proteins.
Qingxin Li, Congbao Kang
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SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model
Science, 2021 Targeting the SARS-CoV-2 main protease Vaccines are an important tool in the fight against COVID-19, but developing antiviral drugs is also a high priority, especially with the rise of variants that may partially evade vaccines.
J. Qiao +42 more
semanticscholar +1 more source
A modular system to evaluate the efficacy of protease inhibitors against HIV-2.
PLoS ONE, 2014 The human immunodeficiency virus (HIV) protease is a homodimeric aspartyl protease that is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious ...
Mohamed Mahdi +3 more
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Advancement in the Development of Therapeutics Against Zika Virus Infection
Frontiers in Cellular and Infection Microbiology, 2022 Zika virus (ZIKV), a re-emerging arbovirus, causes teratogenic effects on the fetus and normal nerve functions, resulting in harmful autoimmune responses, which call for the development of therapeutics against ZIKV infection. In this review, we introduce
Kangchen Li +3 more
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