Results 1 to 10 of about 453,551 (282)

Small Molecule Protease Inhibitors as Model Peptidomimetics [PDF]

Pharmaceuticals
Proteases constitute one of the largest sub-classes of enzymes, accounting for ca. 2% of the proteins encoded in the human genome. They play a key role in protein degradation and signaling, regulating a variety of physiological processes.
Patricia Gomez-Gutierrez, Juan J. Perez
doaj   +2 more sources

Optimized pipeline and designer cells for synthetic-biology-based high-throughput screening of viral protease inhibitors [PDF]

Cell Reports: Methods
Summary: A reliable, efficient, high-throughput pipeline to evaluate viral protease inhibitors would enhance antiviral drug discovery. Methods such as crystallography and phenotypic screening are often constrained by complex assay conditions, limited ...
Shlomi Edri, Shayma El-Atawneh, Tehila Ernst, Maayan Elnekave, Chaja Katzman, Tali Lanton, Ido Aldar, Omri Wolk, Noa Stern, Amiram Goldblum, Lior Nissim   +10 more
doaj   +2 more sources

Efficacy and safety of 3CL protease inhibitors in patients with mild or moderate COVID-19: a systematic review and meta-analysis of randomized controlled trials [PDF]

Virology Journal
Background Remdesivir has been established as a safe treatment for patients with COVID-19. However, given the SARS-CoV-2 random mutations, 3CL protease inhibitors have been studied in recent randomized controlled trials.
Nicole Jean Lee, Eric Shih Katsuyama, Christian Ken Fukunaga, Wilson Falco Neto, Ana Carolina Covre Coan, Hilaria Saugo Faria, Eduardo Alexandrino Medeiros   +6 more
doaj   +2 more sources

Comparative study of the unbinding process of some HTLV-1 protease inhibitors using unbiased molecular dynamics simulations.

PLoS ONE, 2022
The HTLV-1 protease is one of the major antiviral targets to overwhelm this virus. Several research groups have developed protease inhibitors, but none has been successful.
Fereshteh Noroozi Tiyoula, Hassan Aryapour, Mostafa Javaheri Moghadam   +2 more
doaj   +1 more source

HIV Protease: Historical Perspective and Current Research

Viruses, 2021
The retroviral protease of human immunodeficiency virus (HIV) is an excellent target for antiviral inhibitors for treating HIV/AIDS. Despite the efficacy of therapy, current efforts to control the disease are undermined by the growing threat posed by ...
Irene T. Weber, Yuan-Fang Wang, Robert W. Harrison   +2 more
doaj   +1 more source

Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms

Frontiers in Microbiology, 2020
Biofilms formed by the fungal pathogen Candida albicans are resistant to many of the antifungal agents commonly used in the clinic. Previous reports suggest that protease inhibitors, specifically inhibitors of aspartyl proteases, could be effective ...
Matthew B. Lohse, Matthew B. Lohse, Megha Gulati, Charles S. Craik, Alexander D. Johnson, Clarissa J. Nobile   +5 more
doaj   +1 more source

Triple Therapy with First Generation Protease Inhibitors for Hepatitis C Markedly Impairs Function of Neutrophil Granulocytes. [PDF]

PLoS ONE, 2016
First-generation HCV protease inhibitors represent a milestone in antiviral therapy for chronic hepatitis C infection (CHC), but substantially increased rates of viral clearance are offset by increased rates of infection and infection-associated deaths ...
Walter Spindelboeck, Angela Horvath, Monika Tawdrous, Bianca Schmerböck, Gabriele Zettel, Andreas Posch, Andrea Streit, Petra Jurse, Sandra Lemesch, Martin Horn, Gerit Wuensch, Philipp Stiegler, Rudolf E Stauber, Bettina Leber, Vanessa Stadlbauer   +14 more
doaj   +1 more source

NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile virus NS2B-NS3 protease. [PDF]

PLoS Neglected Tropical Diseases, 2009
BACKGROUND: The two-component NS2B-NS3 proteases of West Nile and dengue viruses are essential for viral replication and established targets for drug development.
Xun-Cheng Su, Kiyoshi Ozawa, Ruhu Qi, Subhash G Vasudevan, Siew P Lim, Gottfried Otting   +5 more
doaj   +1 more source

SjAPI, the first functionally characterized Ascaris-type protease inhibitor from animal venoms. [PDF]

PLoS ONE, 2013
Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type ...
Zongyun Chen, Bin Wang, Jun Hu, Weishan Yang, Zhijian Cao, Renxi Zhuo, Wenxin Li, Yingliang Wu   +7 more
doaj   +1 more source

The association between protease inhibitors and anal cancer outcomes in veterans living with HIV treated with definitive chemoradiation: a retrospective study

BMC Cancer, 2021
Background The incidence of anal squamous cell carcinoma has been increasing, particularly in people living with HIV (PLWH). There is concern that radiosensitizing drugs, such as protease inhibitors, commonly used in the management of HIV, may increase ...
Alison K. Yoder, David S. Lakomy, Yongquan Dong, Suchismita Raychaudhury, Kathryn Royse, Christine Hartman, Peter Richardson, Donna L. White, Jennifer R. Kramer, Lilie L. Lin, Elizabeth Chiao   +10 more
doaj   +1 more source