Results 21 to 30 of about 3,925 (50)

Susceptibility of HPV-18 Cancer Cells to HIV Protease Inhibitors

Viruses
Cervical cancer cases continue to rise despite all the advanced screening and preventative measures put in place, which include human papillomavirus (HPV) vaccination.
Lilian Makgoo, Salerwe Mosebi, Zukile Mbita   +2 more
doaj   +1 more source

Detecção de inibidores de proteases em sementes de Punica granatum

Química Nova
The use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation.
Lara Franca Colares, Antero Ricardo Santos Neto, Isac Henrique Cordeiro, Sandra Bertelli Ribeiro de Castro, Rodrigo Moreira Verly, Caio Cesar de Souza Alves, Alessandra de Paula Carli   +6 more
doaj   +1 more source

Inhibitory Effect of Protease Inhibitors on Larval Midgut Protease Activities and the Performance of Plutella xylostella (Lepidoptera: Plutellidae)

Frontiers in Physiology, 2019
Plutella xylostella L. (diamondback moth) is a pest of cruciferous plants. To understand the relationship among protease inhibitors, protease activities and the growth and development of this insect, the activities of midgut proteases of P.
Aiping Zhao, Aiping Zhao, Yin Li, Yin Li, Chunmeng Leng, Chunmeng Leng, Ping Wang, Yiping Li, Yiping Li   +8 more
doaj   +1 more source

Advancement in the Development of Therapeutics Against Zika Virus Infection

Frontiers in Cellular and Infection Microbiology, 2022
Zika virus (ZIKV), a re-emerging arbovirus, causes teratogenic effects on the fetus and normal nerve functions, resulting in harmful autoimmune responses, which call for the development of therapeutics against ZIKV infection. In this review, we introduce
Kangchen Li, Qianting Ji, Shibo Jiang, Naru Zhang   +3 more
doaj   +1 more source

Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction

Frontiers in Cellular and Infection Microbiology, 2017
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Jindřich Chmelař, Jan Kotál, Jan Kotál, Helena Langhansová, Helena Langhansová, Michail Kotsyfakis   +5 more
doaj   +1 more source

C-Terminal Extended Hexapeptides as Potent Inhibitors of the NS2B-NS3 Protease of the ZIKA Virus

Frontiers in Medicine, 2022
The Zika virus (ZIKV) protease is an attractive drug target for the design of novel inhibitors to control the ZIKV infection. As the protease substrate-binding site contains acidic residues, inhibitors with basic residues can be beneficial for the ...
Suyash Pant, Nihar R. Jena
doaj   +1 more source

HIV-1 Protease: Structural Perspectives on Drug Resistance

Viruses, 2009
Antiviral inhibitors of HIV-1 protease are a notable success of structure-based drug design and have dramatically improved AIDS therapy. Analysis of the structures and activities of drug resistant protease variants has revealed novel molecular mechanisms
Irene T. Weber, Johnson Agniswamy
doaj   +1 more source

Comparative proteome analysis of multi-layer cocoon of the silkworm, Bombyx mori. [PDF]

PLoS ONE, 2015
Bombyx mori cocoon has a multi-layer structure that provides optimal protection for silkworm pupa. Research on the mechanical properties of the multi-layer structure revealed structure-property relationships of the cocoon.
Yan Zhang, Ping Zhao, Zhaoming Dong, Dandan Wang, Pengchao Guo, Xiaomeng Guo, Qianru Song, Weiwei Zhang, Qingyou Xia   +8 more
doaj   +1 more source

Commentary on the role of treatment-related HIV compensatory mutations on increasing virulence: new discoveries twenty years since the clinical testing of protease inhibitors to block HIV-1 replication

BMC Medicine, 2012
Approximately 20 years has passed since the first human trial with HIV-1 protease inhibitors. Protease inhibitors set the stage for combination therapy in the mid-1990s but are now rarely used in first-line combination therapy and reserved for salvage ...
Arts Eric J
doaj   +1 more source

Protease Inhibitors from Marine Venomous Animals and Their Counterparts in Terrestrial Venomous Animals

Marine Drugs, 2013
The Kunitz-type protease inhibitors are the best-characterized family of serine protease inhibitors, probably due to their abundance in several organisms.
Caroline B. F. Mourão, Elisabeth F. Schwartz   +1 more
doaj   +1 more source