Results 31 to 40 of about 3,573,509 (380)
ACS Pharmacology & Translational Science, 2020 Among the drug targets being investigated for SARS-CoV-2, the viral main protease (Mpro) is one of the most extensively studied. Mpro is a cysteine protease that hydrolyzes the viral polyprotein at more than 11 sites.
Chunlong Ma +6 more
semanticscholar +1 more source
Triple Therapy with First Generation Protease Inhibitors for Hepatitis C Markedly Impairs Function of Neutrophil Granulocytes. [PDF]
PLoS ONE, 2016 First-generation HCV protease inhibitors represent a milestone in antiviral therapy for chronic hepatitis C infection (CHC), but substantially increased rates of viral clearance are offset by increased rates of infection and infection-associated deaths ...
Walter Spindelboeck +14 more
doaj +1 more source
Inhibitors of rhomboid proteases [PDF]
Biochimie, 2016 Rhomboid proteases form one of the most widespread families of intramembrane proteases. They utilize a catalytic serine-histidine dyad located several Å below the surface of the membrane for substrate hydrolysis. Multiple studies have implicated rhomboid proteases in biologically and medically relevant processes. Several assays have been developed that
Eliane V. Wolf +2 more
openaire +3 more sources
BMC Cancer, 2021 Background The incidence of anal squamous cell carcinoma has been increasing, particularly in people living with HIV (PLWH). There is concern that radiosensitizing drugs, such as protease inhibitors, commonly used in the management of HIV, may increase ...
Alison K. Yoder +10 more
doaj +1 more source
Fractional-order susceptible-infected model: definition and applications to the study of COVID-19 main protease [PDF]
, 2020 We propose a model for the transmission of perturbations across the amino acids of a protein represented as an interaction network. The dynamics consists of a Susceptible-Infected (SI) model based on the Caputo fractional-order derivative.
Abadias, Luciano +2 more
core +2 more sources
Frontiers in Microbiology, 2020 Biofilms formed by the fungal pathogen Candida albicans are resistant to many of the antifungal agents commonly used in the clinic. Previous reports suggest that protease inhibitors, specifically inhibitors of aspartyl proteases, could be effective ...
Matthew B. Lohse +5 more
doaj +1 more source
SjAPI, the first functionally characterized Ascaris-type protease inhibitor from animal venoms. [PDF]
PLoS ONE, 2013 Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type ...
Zongyun Chen +7 more
doaj +1 more source
Binding site analysis of potential protease inhibitors of COVID-19 using AutoDock
VirusDisease, 2020 Recent outbreak of COVID-19 caused by SARS-CoV-2 in December 2019 raised global health concerns. Re-purposing the available protease inhibitor drugs for immediate use in treatment in SARS-CoV-2 infections could improve the currently available clinical ...
D. Mothay, K. V. Ramesh
semanticscholar +1 more source
Viral Protease Inhibitors [PDF]
, 2009 This review provides an overview of the development of viral protease inhibitors as antiviral drugs. We concentrate on HIV-1 protease inhibitors, as these have made the most significant advances in the recent past. Thus, we discuss the biochemistry of HIV-1 protease, inhibitor development, clinical use of inhibitors, and evolution of resistance.
Celia A. Schiffer +3 more
openaire +3 more sources
NMR analysis of the dynamic exchange of the NS2B cofactor between open and closed conformations of the West Nile virus NS2B-NS3 protease. [PDF]
PLoS Neglected Tropical Diseases, 2009 BACKGROUND: The two-component NS2B-NS3 proteases of West Nile and dengue viruses are essential for viral replication and established targets for drug development.
Xun-Cheng Su +5 more
doaj +1 more source