Results 31 to 40 of about 695,446 (323)

Norovirus Protease Structure and Antivirals Development

Viruses, 2021
Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or antiviral drugs available.
Boyang Zhao, Liya Hu, Yongcheng Song, Ketki Patil, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, B. V. Venkataram Prasad   +7 more
doaj   +1 more source

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection [PDF]

, 2017
Urinary tract infections: targeting enzymes might help Identifying bacterial and host enzymes that support biofilm formation may help prevent urinary tract infections caused by catheters.
Caparon, Michael G, Cusumano, Zachary T, Flores-Mireles, Ana L, Hultgren, Scott J, Takagi, Enzo, Xu, Wei   +5 more
core   +3 more sources

Personalizing HIV therapy, mission impossible? [PDF]

, 2012
Sustained HIV suppression depends on a number of factors including therapy adherence, management of side effects, viral resistance and individual characteristics of patients and therapeutic settings.
Hentig, Nils von
core   +1 more source

Inhibitory Effect of Protease Inhibitors on Larval Midgut Protease Activities and the Performance of Plutella xylostella (Lepidoptera: Plutellidae)

Frontiers in Physiology, 2019
Plutella xylostella L. (diamondback moth) is a pest of cruciferous plants. To understand the relationship among protease inhibitors, protease activities and the growth and development of this insect, the activities of midgut proteases of P.
Aiping Zhao, Aiping Zhao, Yin Li, Yin Li, Chunmeng Leng, Chunmeng Leng, Ping Wang, Yiping Li, Yiping Li   +8 more
doaj   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Brew K., Kitts P.A., Kos J., Kotzsch M., Lah T.T., Magdolen U., Possee R.D., Rabbani S.A., Reuning U., Stetler-Stevenson W.G., Szpaderska A.M., Thomas C.J.   +11 more
core   +2 more sources

Restriction of Viral Glycoprotein Maturation by Cellular Protease Inhibitors

Viruses
The human genome is estimated to encode more than 500 proteases performing a wide range of important physiological functions. They digest proteins in our food, determine the activity of hormones, induce cell death and regulate blood clotting, for example.
Rishikesh Lotke, Moritz Petersen, Daniel Sauter   +2 more
doaj   +1 more source

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. [PDF]

, 2016
Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets.
Carpenter, Elisabeth P, Gault, Joseph, Marcoux, Julien, Mehmood, Shahid, Michaelis, Susan, Quigley, Andrew, Robinson, Carol V, Young, Stephen G   +7 more
core   +2 more sources

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]

, 2010
BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Brinen, Linda S, Chen, Yen Ting, Doyle, Patricia S, Hansell, Elizabeth, Kerr, Iain D, McKerrow, James H, Roush, William R   +6 more
core   +3 more sources

Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]

, 2011
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet, Amberg, Sean M, Chen, Yen Ting, Craik, Charles S, Goetz, David H, Hansell, Elizabeth, Lu, Kai, McKerrow, James, Roush, William R, Simmons, Graham, Zhou, Yanchen   +10 more
core   +1 more source

Detecção de inibidores de proteases em sementes de Punica granatum

Química Nova
The use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation.
Lara Franca Colares, Antero Ricardo Santos Neto, Isac Henrique Cordeiro, Sandra Bertelli Ribeiro de Castro, Rodrigo Moreira Verly, Caio Cesar de Souza Alves, Alessandra de Paula Carli   +6 more
doaj   +1 more source