Results 211 to 220 of about 563,257 (338)

Lopinavir-ritonavir is not an effective inhibitor of the main protease activity of SARS-CoV-2 in vitro [PDF]

, 2020
Minsu Jang, Yea–In Park, Rackhyun Park, Yeo-Eun Cha, Sim Namkoong, Jin I. Lee, Junsoo Park   +6 more
openalex   +1 more source

Catalytically Active Recombinant Cysteine Proteases of <i>Haemonchus contortus:</i> Their Ability to Degrade Host Blood Proteins and Modulate Coagulation. [PDF]

Int J Mol Sci
Karunakaran AC, Bakshi M, Rajendrakumar AM, Wilson-Welder JH, Aroian RV, Schwarz EM, Homan EJ, Ostroff GR, Beshah E, Miramontes E, Papadopoulos MD, Bowdridge SA, Zarlenga DS, Zhu X, Tuo W.   +14 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The Role of Extracellular Proteases and Extracellular Matrix Remodeling in the Pre-Metastatic Niche. [PDF]

Biomolecules
Okura GC, Bharadwaj AG, Waisman DM.
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

De N ovo -Designed Miniprotein Inhibits the Enzymatic Activity of the SARS-CoV-2 Main Protease

Tayná Evily de Lima, Emerson G. Moreira, Danilo F. Coêlho, Carlos Cruz, Rafael Dhália, Bruno Leite, Lícya S.S. Xavier, Marta Illana, Gabriel Luz Wallau, Isabelle F. T. Viana, Roberto D. Lins   +10 more
openalex   +1 more source

Plant phytaspases and animal caspases: structurally unrelated death proteases with a common role and specificity [PDF]

, 2011
Nina V. Chichkova, Alexander I. Tuzhikov, Michael Taliansky, Andrey B. Vartapetian   +3 more
openalex   +1 more source

Improved genome assembly of Onygena corvina, a keratin-degrading fungus. [PDF]

BMC Res Notes
Pavale S, Eijsink VGH, La Rosa SL.
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Pathogen-inspired engineering of plant protease enhances late blight resistance. [PDF]

Proc Natl Acad Sci U S A
Huang J, Penrose A, Ossorio Carballo L, van der Hoorn RAL.   +3 more
europepmc   +1 more source