Results 231 to 240 of about 771,571 (414)

3D In Vitro Glioma‐Neuron‐Astrocyte Biomimetic Composites Recapitulate Key Molecular Mechanisms Linked to Glioblastoma Multiforme Pathophysiology

Advanced Functional Materials, EarlyView.
Glioblastoma multiforme is the most devastating and incurable brain tumor. To better study this disease, a 3D model is developed using a hyaluronic acid‐based hydrogel combined with a multicellular approach. This model recapitulates in vivo brain stiffness, cell‐extracellular matrix and cell‐cell interactions and the tumor's hijacking function with the
Mateo S. Andrade Mier, Esra Türker, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Panthipa Suwannakot, Benedikt Gantert, Abhinav Singh, Vanessa Moessler, Annemarie Sodmann, Nicoletta Murenu, Joachim Schenk, Natascha Schaefer, Torsten Blunk, Aldo R. Boccaccini, Tessa C. Lühmann, Jörg Tessmar, Jeremy M. Crook, Eva Tomaskovic‐Crook, Paul D. Dalton, Gregor Lang, Robert Blum, Reiner Strick, Silvia Budday, Katrin G. Heinze, Carmen Villmann   +26 more
wiley   +1 more source

The N-terminal PA domains of signal-peptide-peptidase-like 2 (SPPL2) proteases impact on TNFα cleavage. [PDF]

Commun Biol
Schlosser C, Sharrouf K, Papadopoulou AA, Haug-Kröper M, Singh S, Johler M, Pettinger J, Horn H, Koch M, Hoeppner S, Fluhrer R.   +10 more
europepmc   +1 more source

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Staphylococcus aureus SspA (V8 protease): New skin pathogenesis insights into an old enzyme. [PDF]

PLoS Pathog
Thorstenson JC, Horswill AR.
europepmc   +1 more source

On the Naturally Occurring Inhibitors of Aspergillus-protease

, 1957
Kin’ichi Matsushima
openalex   +2 more sources

Studies on the mode of action of excess of vitamin A. 2. A possible role of intracellular proteases in the degradation of cartilage matrix [PDF]

, 1961
J. A. Lucy, J. T. Dingle, Honor B. Fell
openalex   +1 more source

Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV

Journal of Enzyme Inhibition and Medicinal Chemistry, 2016
Ji-Young Park, Jin-A Ko, D. Kim, Young Min Kim, Hyung-Jun Kwon, Hyung Jae Jeong, Cha Young Kim, K. Park, W. Lee, Y. Ryu   +9 more
semanticscholar   +1 more source

Non‐Enzymatic Destruction of the Extracellular Matrix for Activatable Orthotopic Tumor Treatment and Enhanced Drug Penetration

Advanced Functional Materials, EarlyView.
Supramolecular biomimetic nanoaggregates (HFCu NAs), constructed with fluorinated histidine and copper ions via metal coordination and aromatic packing, exhibit enhanced reactive oxygen species （ROS）generation at tumor sites, which results in stepwise collapse of the extracellular matrix (ECM), affording tumor microenvironment responsive “turn‐on” 19F ...
Hui Wang, Ruxin Feng, Yan Wang, Qian Ma, Di Yuan, Xi Yang, Suying Xu, Tony D. James, Leyu Wang   +8 more
wiley   +1 more source

Paritaprevir as a pan-antiviral against different flaviviruses. [PDF]

Front Mol Biosci
Yadav RP, Jena NR.
europepmc   +1 more source

STUDIES ON THE SPECIFIC PROPERTIES OF PROTEASE AND AMYLASE FROM THE STANDPOINT OF THE ADSORPTION PHENOMENA

, 1929
Fumiwo Hemmi, Goro Inami
openalex   +2 more sources