Results 231 to 240 of about 331,217 (249)

Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis

Advanced Healthcare Materials, EarlyView.
Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim, Sung Sik Hur, Jae Hong Park, Myung Jin Ban, Jin‐Young Kim, Joo Hyun Kim, Ji Hyae Choo, Hae‐Won Kim, Ju Hun Lee, Man Ryul Lee, Yongsung Hwang   +10 more
wiley   +1 more source

1,2,4-Thiadiazolidin-3,5-Diones as Inhibitors of Cysteine Proteases. [PDF]

Molecules
Juliano MA, Persico M, Severino B, Tumbarello G, Okamoto D, Fernandes KR, Trigo G, Tanaka AS, Lacerda JT, Tkachuck O, Corvino A, Fiorino F, Scognamiglio A, Frecentese F, Santagada V, Vertuccio S, Caliendo G, Juliano L, Fattorusso C.   +18 more
europepmc   +1 more source

Bone‐Derived dECM Hydrogels Support Tunable Microenvironments for In Vitro Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Minne Dekker, Luke Hipwood, Akhilandeshwari Ravichandran, Dietmar W. Hutmacher, Christoph Meinert, Jacqui McGovern   +5 more
wiley   +1 more source

Novel thrombolytic protease from the rare halophile Brachybacterium paraconglomeratum: bioprocessing and in vitro application. [PDF]

BMC Biotechnol
Teja M, Jarso TS, Kumar DM, Godi S.
europepmc   +1 more source

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

Advanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li, Elliya Park, Chunsheng He, Azhar Z. Abbasi, Pei Zhi, Paul E. Fraser, Andrew M. Rauth, Jeffery T. Henderson, Xiao Yu Wu   +8 more
wiley   +1 more source

Phenotype switching in highly invasive resistant to vemurafenib and cobimetinib melanoma cells. [PDF]

Cell Commun Signal
Simiczyjew A, Kot M, Majkowski M, Ziętek M, Matkowski R, Nowak D.   +5 more
europepmc   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Mast Cell Association with the Microenvironment of a Phosphaturic Mesenchymal Tumour Secreting Fibroblast Growth Factor 23. [PDF]

Med Sci (Basel)
Kostin A, Lyundup A, Alekhnovich A, Prikhodko A, Patsap O, Gronskaia S, Belaya Z, Lesnyak O, Melnichenko G, Mokrysheva N, Buchwalow I, Tiemann M, Atiakshin D.   +12 more
europepmc   +1 more source

Xeno‐Free Biocompatible Peptide‐Based Bioinks Reinforced with Cellulose Nanofibers for 3D Printing

Advanced Healthcare Materials, EarlyView.
A xeno‐free bioink combining self‐assembled peptides and cellulose nanofibers is developed for 3D printing. The bioink forms a non‐cross‐linked 3D scaffold, mimicking the extracellular matrix and supporting over 95% cell viability. This approach offers enhanced biocompatibility and mechanical stability, advancing 3D printing for personalized medicine ...
Francesca Netti, Mor Tsuriano, Noam Rattner, Vania Altobelli, Yoav Dan, Lihi Adler‐Abramovich   +5 more
wiley   +1 more source

Optimizing mung bean and soybean hydrolysis for the generation of bioactive peptides of potential functional food applications. [PDF]

Food Chem X
Kiss A, Elhawat N, Kovács Z, Kaszás L, Béni Á, Domokos-Szabolcsy É, Alshaal T.   +6 more
europepmc   +1 more source