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Functional Characterization of Secreted Aspartyl Proteases in
mSphere, 2019 Candida parapsilosis is an emerging non-albicans Candida species that largely affects low-birth-weight infants and immunocompromised patients. Fungal pathogenesis is promoted by the dynamic expression of diverse virulence factors, with secreted ...
Dhirendra Kumar Singh +10 more
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Journal of BioScience and Biotechnology, 2021 Endophytic fungi have been in the spotlight as a reservoir of novel agents with diverse bioactivities. Similarity in chemical diversity with the host plant makes them an amenable target for industrial interventions. A wide range of compounds as secondary
Neha Kapoor +2 more
doaj
mSphere, 2016 The Spl proteases are a group of six serine proteases that are encoded on the νSaβ pathogenicity island and are unique to Staphylococcus aureus. Despite their interesting biochemistry, their biological substrates and functions in virulence have been ...
Alexandra E. Paharik +5 more
doaj +1 more source
Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB [PDF]
, 2013 Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping
Coombs, Graham H +5 more
core +1 more source
Interdependence of kallikrein-related peptidases in proteolytic networks [PDF]
, 2010 Human kallikrein-related peptidases (KLKs) are 15 homologous serine proteases involved in several (patho)physiological processes, including cancer. Secreted as precursors, they are activated upon proteolytic release of a short propeptide. We searched for
Debela +21 more
core +1 more source
Proteases as therapeutics [PDF]
Biochemical Journal, 2011 Proteases are an expanding class of drugs that hold great promise. The U.S. FDA (Food and Drug Administration) has approved 12 protease therapies, and a number of next generation or completely new proteases are in clinical development. Although they are a well-recognized class of targets for inhibitors, proteases themselves have not typically been ...
Michael J. Page +2 more
openaire +3 more sources
Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]
, 2003 Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Brew K. +11 more
core +2 more sources
mBio, 2020 Affordable and effective antiviral therapies are needed worldwide, especially against agents such as dengue virus that are endemic in underserved regions.
Jasmine Moshiri +9 more
doaj +1 more source
Defense and Offense Strategies: The Role of Aspartic Proteases in Plant–Pathogen Interactions
Biology, 2021 Plant aspartic proteases (APs; E.C.3.4.23) are a group of proteolytic enzymes widely distributed among different species characterized by the conserved sequence Asp-Gly-Thr at the active site.
Laura Figueiredo +2 more
doaj +1 more source
In silico identification of potential natural product inhibitors of human proteases key to SARS-CoV-2 infection [PDF]
Molecules 2020, 25(17), 3822, 2020 Presently, there are no approved drugs or vaccines to treat COVID-19 which has spread to over 200 countries and is responsible for over 3,65,000 deaths worldwide. Recent studies have shown that two human proteases, TMPRSS2 and cathepsin L, play a key role in host cell entry of SARS-CoV-2.
arxiv +1 more source