Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy [PDF]
, 2017 Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly ...
Bascands, Jean-Loup +15 more
core +2 more sources
A Proteolytic Complex Targets Multiple Cell Wall Hydrolases in
mBio, 2018 Carboxy-terminal processing proteases (CTPs) occur in all three domains of life. In bacteria, some of them have been associated with virulence. However, the precise roles of bacterial CTPs are poorly understood, and few direct proteolytic substrates have
Disha Srivastava +5 more
doaj +1 more source
Animals, 2022 This study is a continuation of the innovative research of the impact of rearing of bee colonies simultaneously on standard- and small-cell combs on the traits of worker bees and bee colonies.
Piotr Dziechciarz +2 more
doaj +1 more source
Cysteine proteases in protozoan parasites
PLoS Neglected Tropical Diseases, 2018 Cysteine proteases (CPs) play key roles in the pathogenesis of protozoan parasites, including cell/tissue penetration, hydrolysis of host or parasite proteins, autophagy, and evasion or modulation of the host immune response, making them attractive ...
J. Siqueira-Neto +6 more
semanticscholar +1 more source
Vibrio proteases for biomedical applications: Modulating the proteolytic secretome of v. alginolyticus and v. parahaemolyticus for improved enzymes production [PDF]
, 2019 Proteolytic enzymes are of great interest for biotechnological purposes, and their large-scale production, as well as the discovery of strains producing new molecules, is a relevant issue.
Ghersi G. +3 more
core +1 more source
Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2016 A comparative study of the activity of the main lysosomal proteolytic enzymes (cathepsins B and D) in the liver, gonads, muscles, and gills in the White Sea herring, Clupea pallasi maris albi Berg (Clupeidae family), caught in different bays (Onega ...
Nina Nemova +2 more
doaj +1 more source
Amino acid frequency and domain features serve well for random forest based classification of thermophilic and mesophilic protein; a case study on serine proteases [PDF]
arXiv, 2021 Thermostability is an important prerequisite for enzymes employed for industrial applications. Several machine learning based models have thus been formulated for protein classification based on this particular trait. These models have employed features derived from sequences, structures or both resulting in a >93% accuracy based on a 10-fold cross ...
arxiv
In vitro protease cleavage and computer simulations reveal the HIV-1 capsid maturation pathway [PDF]
Nature Communications 2016; 7: 13689, 2016 HIV-1 virions assemble as immature particles containing Gag polyproteins that are processed by the viral protease into individual components, resulting in the formation of mature infectious particles. There are two competing models for the process of forming the mature HIV-1 core: the disassembly and de novo reassembly model and the non-diffusional ...
arxiv +1 more source
Generic protease detection technology for monitoring periodontal disease
, 2011 Periodontal diseases are inflammatory conditions that affect the supporting tissues of teeth and can lead to destruction of the bone support and ultimately tooth loss if untreated.
Cook, Joseph P. +6 more
core +1 more source
SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. [PDF]
, 2018 BackgroundSerine proteases are important virulence factors for many pathogens. Recently, we discovered a group of trypsin-like serine proteases with domain organization unique to flatworm parasites and containing a thrombospondin type 1 repeat (TSR-1 ...
Caffrey, Conor R +13 more
core +2 more sources