Results 61 to 70 of about 563,257 (338)

A mathematical model for targeting chemicals to tissues by exploiting complex degradation

Biology Direct, 2011
Background In many biological and therapeutic contexts, it is highly desirable to target a chemical specifically to a particular tissue where it exerts its biological effect. In this paper, we present a simple, generic, mathematical model that elucidates
Grodzinsky Alan J, Pivonka Peter, Smith David W, Zhang Lihai, Gardiner Bruce S   +4 more
doaj   +1 more source

Identification of Antioxidative Peptides Derived from Arthrospira maxima in the Biorefinery Process after Extraction of C-Phycocyanin and Lipids

Marine Drugs, 2023
Arthrospira maxima has been identified as a sustainable source of rich proteins with diverse functionalities and bioactivities. After extracting C-phycocyanin (C-PC) and lipids in a biorefinery process, the spent biomass still contains a large proportion
Renao Bai, Trung T. Nguyen, Yali Zhou, Yong Diao, Wei Zhang   +4 more
doaj   +1 more source

Development of an improved Pseudoalteromonas haloplanktis TAC125 strain for recombinant protein secretion at low temperature [PDF]

, 2008
Background: In a previous paper, we reported the accomplishment of a cold gene-expression system for the recombinant secretion of heterologous proteins in Pseudoalteromonas haloplanktis TAC125.
CIRULLI C., DE VIZIO D., PARRILLI, ERMENEGILDA, TUTINO, MARIA LUISA   +3 more
core   +1 more source

A predator-prey interaction between a marine Pseudoalteromonas sp. and Gram-positive bacteria [PDF]

, 2020
Predator-prey interactions play important roles in the cycling of marine organic matter. Here we show that a Gram-negative bacterium isolated from marine sediments (Pseudoalteromonas sp.
Chen, Xiu-Lan, Chen, Yin, Ding, Haitao, Li, Chun-Yang, Lidbury, Ian, McMinn, Andrew, Su, Hai-Nan, Tang, Bai-Lu, Wang, Lei, Wang, Min, Wang, Peng, Yang, Jie, Yu, Yang, Zhang, Xi-Ying, Zhang, Yu-Zhong, Zhao, Hui-Lin, Zhong, Shuai   +16 more
core   +2 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The enzymatic activity of various organs and tissues of Far-Eastern trepang as a system of indicators of maturation and quality of products

Vestnik MGTU, 2018
The activity, substrate-inhibitory specificity, temperature and pH dependence, seasonal changes in proteolytic and nucleolytic enzyme systems of the digestive tract, muscle and reproductive trepangs tissues have been considered.
Pivnenko T. N., Pozdnyakova Yu. M. , Kovalev N. N. , Mikheev E. V. , Esipenko R. V.   +4 more
doaj   +1 more source

A Targeted Computational Screen of the SWEETLEAD Database Reveals FDA-Approved Compounds with Anti-Dengue Viral Activity

mBio, 2020
Affordable and effective antiviral therapies are needed worldwide, especially against agents such as dengue virus that are endemic in underserved regions.
Jasmine Moshiri, David A. Constant, Bowen Liu, Roberto Mateo, Steven Kearnes, Paul Novick, Ritika Prasad, Claude Nagamine, Vijay Pande, Karla Kirkegaard   +9 more
doaj   +1 more source

Proteases, Protease-Activated Receptors, and Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2018
Coagulation activation by the TF (tissue factor) pathway plays pivotal roles in triggering platelets and precipitating acute coronary syndromes. Although dual antiplatelet therapy is effective in secondary cardiovascular prevention, combining platelet antagonism with low-dose aspirin and the oral coagulation FXa antagonist rivaroxaban has a synergistic
openaire   +2 more sources

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]

, 2009
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher, Birchmeier, Bugge, Chirgadze, Collen, Deyi Qiu, Ellis, Ellis, Gherardi, Harris, Herter, Høyer-Hansen, Itoh, Jennifer L. Harris, Juliano Alves, Jun Li, Kate A. Owen, Ke, Kemp, Kilpatrick, Kirchhofer, Kirchhofer, Lamszus, Lee, Lynette M. Kilpatrick, Mangel, Marcotte, Mars, Mars, Matsuoka, Miyazawa, Mizuno, Mohammed, Naldini, Naldini, Qiu, Rahman, Riddick, Schmidt, Shanmukhappa, Shimizu, Shimomura, Steinmetzer, Stephens, Takeuchi, Uehara, Vincent Ellis, You   +47 more
core   +3 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source