Results 71 to 80 of about 771,571 (414)
Biomolecules, 2022 Bacterial biofilms represent multicellular communities embedded in a matrix of extracellular polymeric substances, conveying increased resistance against environmental stress factors but also antibiotics.
Juan Sebastián Ramírez-Larrota +1 more
doaj +1 more source
Benchmarking Deep Graph Generative Models for Optimizing New Drug Molecules for COVID-19 [PDF]
arXiv, 2021 Design of new drug compounds with target properties is a key area of research in generative modeling. We present a small drug molecule design pipeline based on graph-generative models and a comparison study of two state-of-the-art graph generative models for designing COVID-19 targeted drug candidates: 1) a variational autoencoder-based approach (VAE ...
arxiv
Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells
FEBS Letters, EarlyView.Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga +6 more
wiley +1 more source
Rangifer, 1999 Eight reindeer bulls (age 1.5 years) and six Friesian bulls (age 1.5 years) were included in the study for comparison of tenderness. The reindeer were slaughtered at a commercial reindeer slaughter plant in northern Sweden and the Friesian bulls at a ...
V. M.H. Barnier +4 more
doaj +1 more source
Plant Direct, 2023 Salinity is increasingly considered as a major environmental issue, which threatens agricultural production by decreasing yield traits of crops. Seed priming is a useful and cost‐effective technique to alleviate the negative effects of salinity and to ...
Souhir Sghayar +10 more
doaj +1 more source
Aspergillus fumigatus—Host Interactions Mediating Airway Wall Remodelling in Asthma
Journal of Fungi, 2022 Asthma is a chronic heterogeneous respiratory condition that is mainly associated with sensitivity to airborne agents such as pollen, dust mite products and fungi.
Sara Namvar +3 more
doaj +1 more source
Bacterial proteases, untapped antimicrobial drug targets
Journal of antibiotics (Tokyo. 1968), 2016 Bacterial proteases are an extensive collection of enzymes that have vital roles in cell viability, stress response and pathogenicity. Although their perturbation clearly offers the potential for antimicrobial drug development, both as traditional ...
Elizabeth J. Culp, Gerard D. Wright
semanticscholar +1 more source
Proteolytic processing and activation of Clostridium perfringens epsilon toxin by caprine small intestinal contents. [PDF]
, 2014 Epsilon toxin (ETX), a pore-forming toxin produced by type B and D strains of Clostridium perfringens, mediates severe enterotoxemia in livestock and possibly plays a role in human disease.
Freedman, John C +3 more
core +2 more sources
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Biology, 2022 Hybridization is defined as the interbreeding of individuals from two populations distinguishable by one or more heritable characteristics. Snake hybridization represents an interesting opportunity to analyze variability and how genetics affect the venom
Octavio Roldán-Padrón +8 more
doaj +1 more source