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Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease [PDF]
Molecules, 2020 The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
David J. Sherman, Jing Li
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Frontiers in Cell and Developmental Biology, 2023 The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays critical roles in nervous system processes.
Kanisa Davidson, Andrew M. Pickering
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Cells, 2021 Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to hypothermia.
Nagat El Demerdash +6 more
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The 20S as a stand-alone proteasome in cells can degrade the ubiquitin tag
Nature Communications, 2021 The proteasome, the primary protease for ubiquitin-dependent proteolysis in eukaryotes, is usually found as a mixture of 30S, 26S, and 20S complexes. These complexes have common catalytic sites, which makes it challenging to determine their distinctive ...
Indrajit Sahu +14 more
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iScience, 2020 Summary: The proteasome is a therapeutic target in cancer, but resistance to proteasome inhibitors often develops owing to the induction of compensatory pathways.
Eiichi Hashimoto +7 more
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Ubiquitin–proteasome system (UPS) as a target for anticancer treatment
Archives of pharmacal research, 2020 The ubiquitin–proteasome system (UPS) plays an important role in the cellular processes for protein quality control and homeostasis. Dysregulation of the UPS has been implicated in numerous diseases, including cancer.
Jinyoung Park, Jinhong Cho, E. J. Song
semanticscholar +1 more source
Targeted Protein Degradation: Principles and Applications of the Proteasome
Cells, 2023 The proteasome is a multi-catalytic protease complex that is involved in protein quality control via three proteolytic activities (i.e., caspase-, trypsin-, and chymotrypsin-like activities).
Yosup Kim +4 more
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Proteasome Inhibitors for the Treatment of Multiple Myeloma
Cancers, 2020 Use of proteasome inhibitors (PIs) has been the therapeutic backbone of myeloma treatment over the past decade. Many PIs are being developed and evaluated in the preclinical and clinical setting.
S. Ito
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Annual Review of Pharmacology and Toxicology, 2020 Proteasomes are large, multicatalytic protein complexes that cleave cellular proteins into peptides. There are many distinct forms of proteasomes that differ in catalytically active subunits, regulatory subunits, and associated proteins.
L. Fricker
semanticscholar +1 more source
Wiggle and Shake: Managing and Exploiting Conformational Dynamics during Proteasome Biogenesis
Biomolecules, 2023 The 26S proteasome is the largest and most complicated protease known, and changes to proteasome assembly or function contribute to numerous human diseases.
Daniel Betancourt +2 more
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