Results 1 to 10 of about 393,592 (390)
Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease [PDF]
Molecules, 2020 The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
David J. Sherman, Jing Li
doaj +3 more sources
Dynamic Regulation of the 26S Proteasome: From Synthesis to Degradation
Frontiers in Molecular Biosciences, 2019 All eukaryotes rely on selective proteolysis to control the abundance of key regulatory proteins and maintain a healthy and properly functioning proteome.
Richard S Marshall, Richard D Vierstra
exaly +2 more sources
Spatial mechanisms of quality control during chaperone-mediated assembly of the proteasome [PDF]
Nature CommunicationsCellular protein degradation requires a complex molecular machine, the proteasome. To mitigate the fundamental challenge of assembling the 66-subunit proteasome, cells utilize dedicated chaperones to order subunit addition.
Eshita Das +4 more
doaj +2 more sources
Structure- and function-based design of Plasmodium-selective proteasome inhibitors
Nature, 2016 The proteasome is a multi-component protease complex responsible for regulating key processes such as the cell cycle and antigen presentation. Compounds that target the proteasome are potentially valuable tools for the treatment of pathogens that depend ...
Hao Li +2 more
exaly +2 more sources
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
eLife, 2016 Proteasomes are essential for protein homeostasis in eukaryotes. To preserve cellular function, transcription of proteasome subunit genes is induced in response to proteasome dysfunction caused by pathogen attacks or proteasome inhibitor drugs.
Nicolas J Lehrbach, Gary Ruvkun
doaj +2 more sources
Proteasome inhibitors in cancer therapy
Nature Reviews Clinical Oncology, 2017 Elisabet E Manasanch, Robert Z Orlowski
exaly +2 more sources
Regulation of proteasome assembly and activity in health and disease
Nature Reviews Molecular Cell Biology, 2018 Adrien Rousseau, Anne Bertolotti
exaly +2 more sources
, 1990 Inhibitors of the catalytic activity of the 20S proteasome are cytotoxic to tumor cells and are currently in clinical use for treatment of multiple myeloma, whilst the deubiquitinase activity associated with the 19S regulatory subunit of the proteasome ...
D'Arcy, Padraig +9 more
core +13 more sources
Frontiers in Cell and Developmental Biology, 2023 The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays critical roles in nervous system processes.
Kanisa Davidson, Andrew M. Pickering
doaj +1 more source