Results 11 to 20 of about 204,769 (294)
Modelling Proteasome and Proteasome Regulator Activities [PDF]
Biomolecules, 2014 Proteasomes are key proteases involved in a variety of processes ranging from the clearance of damaged proteins to the presentation of antigens to CD8+ T-lymphocytes.
Juliane Liepe +4 more
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Frontiers in Cell and Developmental Biology, 2023 The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays critical roles in nervous system processes.
Kanisa Davidson, Andrew M. Pickering
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Deubiquitination Reactions on the Proteasome for Proteasome Versatility [PDF]
International Journal of Molecular Sciences, 2020 The 26S proteasome, a master player in proteolysis, is the most complex and meticulously contextured protease in eukaryotic cells. While capable of hosting thousands of discrete substrates due to the selective recognition of ubiquitin tags, this protease complex is also dynamically checked through diverse regulatory mechanisms.
Ji Yeong Shin +5 more
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Cells, 2021 Cerebral hypoxia-ischemia (HI) compromises the proteasome in a clinically relevant neonatal piglet model. Protecting and activating proteasomes could be an adjunct therapy to hypothermia.
Nagat El Demerdash +6 more
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Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease
Molecules, 2020 The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
David J. Sherman, Jing Li
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iScience, 2020 Summary: The proteasome is a therapeutic target in cancer, but resistance to proteasome inhibitors often develops owing to the induction of compensatory pathways.
Eiichi Hashimoto +7 more
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Targeted Protein Degradation: Principles and Applications of the Proteasome
Cells, 2023 The proteasome is a multi-catalytic protease complex that is involved in protein quality control via three proteolytic activities (i.e., caspase-, trypsin-, and chymotrypsin-like activities).
Yosup Kim +4 more
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Proteasome in action: substrate degradation by the 26S proteasome [PDF]
Biochemical Society Transactions, 2021 Ubiquitination is the major criteria for the recognition of a substrate-protein by the 26S proteasome. Additionally, a disordered segment on the substrate — either intrinsic or induced — is critical for proteasome engagement. The proteasome is geared to interact with both of these substrate features and prepare it for degradation.
Indrajit Sahu, Michael H. Glickman
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Wiggle and Shake: Managing and Exploiting Conformational Dynamics during Proteasome Biogenesis
Biomolecules, 2023 The 26S proteasome is the largest and most complicated protease known, and changes to proteasome assembly or function contribute to numerous human diseases.
Daniel Betancourt +2 more
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The ubiquitin‐proteasome pathway and proteasome inhibitors [PDF]
Medicinal Research Reviews, 2001 AbstractThe ubiquitin‐proteasome pathway has emerged as a central player in the regulation of several diverse cellular processes. Here, we describe the important components of this complex biochemical machinery as well as several important cellular substrates targeted by this pathway and examples of human diseases resulting from defects in various ...
Craig M. Crews +2 more
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