Results 201 to 210 of about 411,261 (379)

ABCC2 p.R393W variant contributes to Dubin-Johnson syndrome by targeting MRP2 to proteasome degradation [PDF]

Rongyue Sun, Yi‐Ming Chen, Mian-Mian Zhu, Jian Sun, Hongwei Wang, Chenyu Wu, Ting Zhu, Yu-Jing Gong, Chao-Sheng Lu, Luisa Ronzoni, Luca Valenti, Ming‐Hua Zheng, Dan Wang   +12 more
openalex   +1 more source

Proteasome [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

β‐catenin is a target for the ubiquitin–proteasome pathway

, 1997
H. Aberle, A. Bauer, J. Stappert, A. Kispert, R. Kemler   +4 more
semanticscholar   +1 more source

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

Acute Polyglutamine Expression in Inducible Mouse Model Unravels Ubiquitin/Proteasome System Impairment and Permanent Recovery Attributable to Aggregate Formation [PDF]

, 2010
Zaira Ortega, Miguel Dı́az-Hernández, Christa J. Maynard, Félix Hernández, Nico P. Dantuma, José J. Lucas   +5 more
openalex   +1 more source

Bortezomib blocks Bax degradation in malignant B cells during treatment with TRAIL [PDF]

, 2008
Adrian C. Newland, Aguilar-Santelises, Beckwith, Bosanquet, Breitschopf, Brooks, Chang, Chitambar, Chresta, Ciechanover, Clohessy, Dewson, Dohmen, Fandy, Fecker, Feng-Ting Liu, Hao, Hao, Hideshima, Hongtao Ye, Hsu, Inoue, Jia, Jia, Jia, John G. Gribben, Johnson, Kabore, Kelley, Kluin-Nelemans, Kuroda, Lashinger, Li, Li Jia, Liu, Liu, Lotan, Lundqvist, MacFarlane, McConkey, Ming-Qing Du, Mitsiades, Miyashita, Nikrad, Nishii, Pahler, Perez-Galan, Pigneux, Qin, Rudner, Samir G. Agrawal, Saxena, Sayers, Scheffner, Schmitt, Schwartz, Shah, Smolewski, Strauss, Sutheesophon, Upton, Willis   +61 more
core   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells [PDF]

, 2016
Xu Li, Feng Zhu, Jianxin Jiang, Chengyi Sun, Qing Zhong, Ming Shen, Xin Wang, Rui Tian, Chengjian Shi, Meng Xu, Feng Peng, Xingjun Guo, Jun Hu, Dawei Ye, Min Wang, Renyi Qin   +15 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source