Results 201 to 210 of about 204,426 (234)

The mechanism of cell-cycle-dependent proteasomal degradation of archaeal ESCRT-III homolog CdvB in Sulfolobus. [PDF]

EMBO J
Kuo YW, Traparić J, Foo S, Baum B.
europepmc   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

Gambogic acid moderates cardiac responses to chronic hypoxia likely by acting on the proteasome and NF-κB pathway.

, 2013
Canguo Zhao, Shouting Liu, Changshan Yang, Xiaofen Li, Hongbiao Huang, Ningning Liu, Shujue Li, Xuejun Wang, Jinbao Liu   +8 more
openalex   +1 more source

Proteasome and Ribosome Ubiquitination in Retinal Pigment Epithelial (RPE) Cells in Response to Oxidized Low-Density Lipoprotein (OxLDL). [PDF]

Biomedicines
Giorgianni F, Beranova-Giorgianni S.
europepmc   +1 more source

Reduction of RAD23A extends lifespan and mitigates pathology in a mouse model of TDP-43 proteinopathy. [PDF]

Nat Commun
Guo X, Prajapati RS, Chun J, Byun I, Gebis KK, Wang YZ, Ling K, Dalton C, Blair JA, Hamidianjahromi A, Bachmann G, Rigo F, Jafar-Nejad P, Savas JN, Lee MJ, Sreedharan J, Kalb RG.   +16 more
europepmc   +1 more source

Proteasome: Role in T Cell Function Regulation. [PDF]

Int J Biol Sci
Tang D, Wu X, Lei JH, Qiao Y, Deng CX.
europepmc   +1 more source

Beyond degradation tags: How FAT10 and ubiquitin shape substrate energy landscapes. [PDF]

Essays Biochem
Ravichandran A, Sivakumar A, Das R.
europepmc   +1 more source

The proteostasis paradox: from systemic collapse in aging to pathway-specific addiction in prostate cancer. [PDF]

Front Cell Dev Biol
Guo D, Peng Y, Yu Y.
europepmc   +1 more source