Results 261 to 270 of about 1,442,074 (300)

Proteasome Inhibition in Cancer Therapy

Journal of Infusion Nursing, 2005
Multiple myeloma is an incurable malignancy diagnosed for approximately 15,000 individuals in the United States each year. The advances in high-dose chemotherapy and transplantation have improved the overall survival rates and allowed individuals to remain off therapy for longer periods, but relapses are inevitable.
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Anti‐20S proteasome autoantibodies inhibit proteasome stimulation by proteasome activator PA28

Arthritis & Rheumatism, 2006
AbstractObjectiveThe ubiquitin‐proteasome system plays a central role in cellular homeostasis as well as in regulation of the inflammatory and stress responses. However, the occurrence of autoantibodies against 20S proteasome has, to date, been considered to be a nonspecific epiphenomenon in patients with autoimmune disorders. This study was undertaken
Michael, Brychcy, Ulrike, Kuckelkorn, Gert, Hausdorf, Karl, Egerer, Peter M, Kloetzel, Gerd R, Burmester, Eugen, Feist   +6 more
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Proteasome Inhibition and Apoptosis

2004
Programmed cell death is an energy-dependent process of cellular elimination that is necessary in all stages of life, including development, tissue homeostasis, and aging in multicellular organisms. Work by Wyllie, Kerr, and Currie identified the large phenotypic changes in the morphology of cells undergoing programmed cell death such as nuclear ...
Simon A. Williams, David J. McConkey
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Proteasome Inhibition Enhances Lipofuscin Formation

Annals of the New York Academy of Sciences, 2002
Abstract: Lipofuscin, a hallmark of aged nondividing cells, is an undegradable autofluorescent intralysosomal substance composed essentially of oxidized, cross‐linked proteins. To test whether impaired activity of proteasomes—which, along with lysosomes, belong to major cellular proteolytic systems—may contribute to lipofuscinogenesis, we exposed ...
Alexei, Terman, Sara, Sandberg
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Radiosensitization and Proteasome Inhibition

2004
Radiation is an important modality of therapy for a variety of cancers, including squamous cell carcinomas (SCC) of the head and neck and skin. Cell survival and resistance following radiation are mediated by cytoprotective molecules that regulate cellcycle progression and cell death.
Carter Van Waes, John B. Sunwoo, William DeGraff, James B. Mitchell   +3 more
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Role of Proteasome Inhibition in Waldenström's Macroglobulinemia

Clinical Lymphoma and Myeloma, 2009
The paradigm for the treatment of monoclonal gammophaties has dramatically changed: based on the understanding of the complex interaction between tumor cells and bone marrow microenvironment and the signaling pathways that are deregulated in this process, a number of novel therapeutic agents are now available.
Aldo M, Roccaro, Antonio, Sacco, Xavier, Leleu, Abdel Kareem, Azab, Feda, Azab, Judith, Runnels, Xiaoying, Jia, Hai T, Ngo, Molly, Melhem, Anne-Sophie, Moreau, Irene M, Ghobrial   +10 more
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Insights into proteasome inhibition

Science, 2016
Structural Biology Proteasomes are large protein complexes that degrade and remove proteins to maintain proper cellular physiology and growth. Proteasomes are a validated target for anticancer therapy, but drug design has been hampered by poor understanding of how inhibitors interact with the ...
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Potential for Proteasome Inhibition in the Treatment of Cancer

Drug Discovery Today, 2003
Proteasome inhibition is a new approach to treating cancer. Proteasome inhibitors specifically induce apoptosis in cancer cells, but most proteasome inhibitors are not suitable for clinical development. Peptide boronates overcome the shortcomings of earlier generation proteasome inhibitors, and bortezomib (VELCADE; formerly PS-341) is the first peptide
Julian Adams
exaly   +3 more sources

Inhibition of proteasome activity by anthocyanins and anthocyanidins

Biochemical and Biophysical Research Communications, 2008
Recent reports have demonstrated multiple benefits associated with the consumption of berry fruits, including a decreased vulnerability to oxidative stress, reduced ischemic brain damage, protection of neurons from stroke-induced damage and the reversal of age-related changes in brain and behaviour.
Dreiseitel, A, Schreier, P, Oehme, A, Locher, S, Rogler, G, Piberger, H, Hajak, G, Sand, P G   +7 more
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Development of lipopeptides for inhibiting 20S proteasomes

Bioorganic & Medicinal Chemistry Letters, 2006
Proteasomes are responsible for the cytoplasmic turnover of the vast majority of proteins including regulatory proteins. We have synthesized lipopeptides a new class of non-covalent inhibitors of the 20S proteasome and assayed their inhibitory capacities.
Basse, Nicolas, Papapostolou, David, Pagano, Maurice, Reboud-Ravaux, Michèle, Bernard, Élise, Felten, Anne-Sophie, Vanderesse, Régis   +6 more
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