Results 271 to 280 of about 1,442,074 (300)
Some of the next articles are maybe not open access.
Proteasome inhibition and Parkinson's disease modeling
Annals of Neurology, 2006Impaired proteasome function is a potential mechanism for dopaminergic neuron degeneration. To model this molecular defect, we administered systemically the reversible lipophilic proteasome inhibitor, carbobenzoxy-L-isoleucyl-gamma-t-butyl-L-glutamyl-L-alanyl-L-leucinal (PSI), to rodents.
Jordi, Bové +9 more
openaire +2 more sources
Cupriphilic compounds to aid in proteasome inhibition
Bioorganic & Medicinal Chemistry Letters, 2016It has been found that tumor cells and tissues, compared to normal cells, have higher levels of copper and possibly other metal ions. This presents a potential vulnerability of tumor cells that can serve as a physiological difference between cancer cells and normal cells and allows design of compounds that selectively target tumor cells while sparing ...
Sreya Mukherjee +5 more
openaire +2 more sources
Glioblastoma (GBM) is the most aggressive brain cancer in adults. Due to the complexities and dynamic nature inherent to this tumor, effective treatments have been hard to come by. Thus, there is a dire need to discover newer therapies to help manage tumor progression and prevent recurrence.
openaire +1 more source
openaire +1 more source
mTOR Inhibits Starvation-Induced Nuclear Export of the Proteasome
Nature Reviews Molecular Cell Biology, 2023exaly
Inhibition of the proteasome as a therapeutic approach
Drug Discovery Today, 1999openaire +2 more sources
The RNA Exosome and Proteasome: Common Principles of Degradation Control
Nature Reviews Molecular Cell Biology, 2013Elena Conti
exaly
The Power of Proteasome Inhibition in Multiple Myeloma
Expert Review of Proteomics, 2018Sara Gandolfi +2 more
exaly