Results 31 to 40 of about 1,442,074 (300)

Role of S5b/PSMD5 in Proteasome Inhibition Caused by TNF-α/NFκB in Higher Eukaryotes

Cell Reports, 2012
The ubiquitin-proteasome system is essential for maintaining protein homeostasis. However, proteasome dysregulation in chronic diseases is poorly understood.
Sang Mi Shim, Won Jae Lee, Youngdoo Kim, Jong Wook Chang, Sungmin Song, Yong-Keun Jung   +5 more
doaj   +1 more source

The proteasome cap RPT5/Rpt5p subunit prevents aggregation of unfolded ricin A chain [PDF]

, 2013
The plant cytotoxin ricin enters mammalian cells by receptor-mediated endocytosis, undergoing retrograde transport to the endoplasmic reticulum (ER) where its catalytic A chain (RTA) is reductively separated from the holotoxin to enter the cytosol and ...
Spooner, Robert A., Roberts, David M, Roberts, Lynne M, Lord, J Michael, Cook, Jonathan P., Pietroni, Paola, Roberts, David M., Lord, Mike, Roberts, L. M. (Lynne M.), Spooner, Robert A, Vasisht, Nishi, Hartmann-Petersen, Rasmus, Cook, Jonathan P   +12 more
core   +1 more source

Proteasome Inhibition Activates Autophagy-Lysosome Pathway Associated With TFEB Dephosphorylation and Nuclear Translocation

Frontiers in Cell and Developmental Biology, 2019
Ubiquitin-proteasome pathway (UPS) and autophagy-lysosome pathway (ALP) are the two major protein degradation pathways, which are critical for proteostasis.
Chunyan Li, Chunyan Li, Chunyan Li, Xin Wang, Xin Wang, Xuezhi Li, Xuezhi Li, Kaixin Qiu, Kaixin Qiu, Kaixin Qiu, Fengjuan Jiao, Fengjuan Jiao, Yidan Liu, Qingxia Kong, Yan Liu, Yan Liu, Yili Wu, Yili Wu   +17 more
doaj   +1 more source

The proteasome inhibitor MG-132 sensitizes PC-3 prostate cancer cells to ionizing radiation by a DNA-PK-independent mechanism

BMC Cancer, 2005
Background By modulating the expression levels of specific signal transduction molecules, the 26S proteasome plays a central role in determining cell cycle progression or arrest and cell survival or death in response to stress stimuli, including ionizing
McBride William H, Weissenberger Christian, van Ophoven Arndt, Pajonk Frank   +3 more
doaj   +1 more source

Synthesis and proteasome inhibition of lithocholic acid derivatives [PDF]

, 2011
A new class of proteasome inhibitors was synthesized using lithocholic acid as a scaffold. Modification at the C-3 position of lithocholic acid with a series of acid acyl groups yielded compounds with a range of potency on proteasome inhibition.
Chen, Chin Ho, Andrew Lin, Dominique Soroka, Kuo-Hsiung Lee, Huang, Li, Li Huang, Lee, Kuo Hsiung, Zhao Dang, Ho, Phong, Dang, Zhao, Chin-Ho Chen, Soroka, Dominique, Phong Ho, Lin, Andrew   +13 more
core   +1 more source

Failure of amino acid homeostasis causes cell death following proteasome inhibition

, 2012
The ubiquitin-proteasome system targets many cellular proteins for degradation and thereby controls most cellular processes. Although it is well established that proteasome inhibition is lethal, the underlying mechanism is unknown.
Christian Münch, Ariane Hanssum, Munch, Christian, Hanssum, Ariane, Amila Suraweera, Suraweera, Amila, Anne Bertolotti, Bertolotti, Anne   +7 more
core   +1 more source

Proteasome Inhibition and Cancer

, 2021
Cancerous cells arise due to genetic changes in regions of DNA that regulate cell growth, death, and/or motility causing over proliferation and formation of tumors. These cells maintain homeostasis while bypassing cell growth markers.
Montgomery, Damon A., Justice, Sarah
core   +1 more source

Proteasomal Inhibition by α-Synuclein Filaments and Oligomers [PDF]

Journal of Biological Chemistry, 2004
A unifying feature of many neurodegenerative disorders is the accumulation of polyubiquitinated protein inclusions in dystrophic neurons, e.g. containing alpha-synuclein, which is suggestive of an insufficient proteasomal activity. We demonstrate that alpha-synuclein and 20 S proteasome components co-localize in Lewy bodies and show that subunits from ...
Gai, Wei Ping, Beedholm, R, Lindersson, Evo, Hojrup, Peter, Moos, Torben, Jensen, Poul Henning, Hendil, K B   +6 more
openaire   +4 more sources

Proteasome inhibition and its therapeutic potential in multiple myeloma

, 2010
Ajai Chari1, Amitabha Mazumder2, Sundar Jagannath11Mount Sinai School of Medicine, New York, NY, USA; 2New York University School of Medicine, New York, NY, USAAbstract: Due to an unmet clinical need for treatment, the first in class proteasome inhibitor,
Ajai Chari, Amitabha Mazumder, Sundar Jagannath   +2 more
core   +1 more source

Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms

Frontiers in Oncology, 2022
Chordoma is a rare cancer that grows in the base of the skull and along the mobile spine from remnants of embryonic notochord tissue. The cornerstone of current treatments is surgical excision with adjuvant radiation therapy, although complete surgical ...
Christopher J. Walker, Hua Chang, Leah Henegar, Trinayan Kashyap, Sharon Shacham, Josh Sommer, Michael J. Wick, Joan Levy, Yosef Landesman   +8 more
doaj   +1 more source