Results 41 to 50 of about 1,442,074 (300)

Proteasome Inhibition After Burn Injury [PDF]

Journal of Burn Care & Research, 2016
The objective of this study was to assess the effects of proteasome inhibition on the development of burn-induced hypermetabolism. Rats underwent 30-40% total BSA scald burn or sham injury. The proteasome inhibitor bortezomib (0.1 mg/kg) or vehicle (n = 10) was administered i.p. 3× weekly starting at 2 hours (early bortezomib, n = 20) or 48 hours (late-
P Geoff, Vana, Heather M, LaPorte, Yee M, Wong, Richard H, Kennedy, Richard L, Gamelli, Matthias, Majetschak   +5 more
openaire   +2 more sources

The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. [PDF]

, 2014
p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and
J Das, S Menendez, Menendez, S., Saville, M. K., S Dayal, Das, J., M K Saville, Dayal, S., A Sparks, Robertson, P., P Robertson, Sparks, A.   +11 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Inhibition of the Human Proteasome by Imidazoline Scaffolds [PDF]

Journal of Medicinal Chemistry, 2013
The proteasome has emerged as the primary target for the treatment of multiple myeloma. Unfortunately, nearly all patients develop resistance to competitive-type proteasome inhibitors such as bortezomib. Herein, we describe the optimization of noncompetitive proteasome inhibitors to yield derivatives that exhibit nanomolar potency (compound 49, IC50 ...
Lauren M, Azevedo, Theresa A, Lansdell, Jacob R, Ludwig, Robert A, Mosey, Daljinder K, Woloch, Dillon P, Cogan, Gregory P, Patten, Michael R, Kuszpit, Jason S, Fisk, Jetze J, Tepe   +9 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The Proteasome Inhibitor MG-132 Protects Hypoxic SiHa Cervical Carcinoma Cells after Cyclic Hypoxia/Reoxygenation from Ionizing Radiation

Neoplasia: An International Journal for Oncology Research, 2006
INTRODUCTION: Transient hypoxia and subsequent reoxygenation are common phenomena in solid tumors that greatly influence the outcome of radiation therapy.
Frank Pajonk, Thorsten Grumann, William H. McBride   +2 more
doaj   +1 more source

Proteasome inhibition and Nogo-induced growth cone collapse.

, 2014
A/ Proteasome inhibition with Z-LLnL (LLnL) does not inhibit the collapse-inducing activity of 150 nM Nogo-A-Δ20. B/Proteasome inhibition significantly inhibits collapse-inducing activity of 2 nM Nogo-66 (N66).
Prem Jareonsettasin (516817), Martin E. Schwab (474956), Richard Manns (516816), Antonio Schmandke (474954), Geoffrey Cook (516818), Andre Schmandke (474953), Roger Keynes (516820), Christine Holt (516819)   +7 more
core   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Proteasome beta-4 subunit contributes to the development of melanoma and is regulated by miR-148b

Tumor Biology, 2017
The proteasome beta-4 subunit is required for the assembly of 20S proteasome complex, forming a pivotal component for the ubiquitin–proteasome system. Emerging evidence indicates that proteasome beta-4 subunit may be involved in underlying progression ...
Xiaodong Zhang, Di Lin, Yueqin Lin, Hongqing Chen, Minghua Zou, Shan Zhong, Xuefeng Yi, Siqi Han   +7 more
doaj   +1 more source

Proteasome inhibition in hypertrophied myocardium

American Journal of Physiology-Heart and Circulatory Physiology, 2008
cardiac remodeling has been described as both an adaptive and a maladaptive process. The adaptive component enables the heart to maintain function in response to pressure overload and has the effect of decreasing ventricular wall stress and compensates for the increased workload preserving cardiac function.
openaire   +3 more sources