Results 171 to 180 of about 527,152 (301)

Peptide properties predict multistate translocation kinetics via protective antigen nanopores. [PDF]

Biophys J
Colby JM, Krantz BA.
europepmc   +1 more source

Generation of Protein-Phosphorodiamidate Morpholino Oligomer Conjugates for Efficient Cellular Delivery via Anthrax Protective Antigen.

Methods Mol Biol, 2022
Palacio-Castañeda V, Brock R, Verdurmen WPR.   +2 more
europepmc   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

MetE: a promising protective antigen for tuberculosis vaccine development. [PDF]

Front Immunol
Almujri SS, Stylianou E, Nicastri A, Satti I, Korompis M, Li S, De Voss CJ, Polo Peralta Alvarez M, Tanner R, Bettencourt PJG, Ternette N, McShane H.   +11 more
europepmc   +1 more source

Two Cross-Protective Antigen Sites on Foot-and-Mouth Disease Virus Serotype O Structurally Revealed by Broadly Neutralizing Antibodies from Cattle. [PDF]

J Virol, 2021
Li K, He Y, Wang L, Li P, Wang S, Sun P, Bao H, Cao Y, Liu X, Zhu G, Song Y, Bai X, Ma X, Fu Y, Yuan H, Zhang J, Wang J, Chen Y, Li D, Lou Z, Liu Z, Lu Z.   +21 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Label-Free DNA Aptasensor for Detection of Protective Antigen

, 2012
본 논문에서는 별도의 라벨링 과정 없이, PA (보호 항원, protective antigen) 와 결합함에 따라 구조가 변화하고, 이에 따라 형광의 세기나 전기화학적 신호가 변하는 aptasensor와 관련된 연구를 하였다. Part Ⅰ. 에서는 DNA에 별도의 라벨링 과정 없이 PA와 결합함에 따라 형광의 세기가 변하는 aptasensor를 연구하였다.
오별님
core  

Protective antigen-mediated delivery of an anti-CRISPR protein for precision genome editing. [PDF]

Proc Natl Acad Sci U S A
Vera AO, Truex NL, Sreekanth V, Pentelute BL, Choudhary A, Raines RT.   +5 more
europepmc   +1 more source

Reengineering anthrax toxin protective antigen for improved receptor-specific protein delivery. [PDF]

BMC Biol, 2020
Becker L, Verdurmen WPR, Plückthun A.
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source