Results 241 to 250 of about 469,365 (378)

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

IgA antibodies to a protective antigen in human Schistosomiasis mansoni. [PDF]

, 1993
Jean‐Marie Grzych, Délphine Grezel, Cang‐Bao Xu, J.L. Neyrinck, Moníque Capron, John H. Ouma, A Butterworth, A Capron   +7 more
openalex   +1 more source

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

Advanced Science, EarlyView.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen   +7 more
wiley   +1 more source

Characterization of the Biodistribution of a Silica Vesicle Nanovaccine Carrying a Rhipicephalus (Boophilus) microplus Protective Antigen With in vivo Live Animal Imaging. [PDF]

Front Bioeng Biotechnol, 2020
Mody KT, Zhang B, Li X, Fletcher NL, Akhter DT, Jarrett S, Zhang J, Yu C, Thurecht KJ, Mahony TJ, Mitter N.   +10 more
europepmc   +1 more source

Trypanosoma cruzi: immunity-induced in mice and rats by trypomastigote excretory-secretory antigens and identification of a peptide sequence containing a T cell epitope with protective activity. [PDF]

, 1993
A. Taibi, B. Plumas-Marty, A. Guevara-Espinoza, Ralf Schöneck, Hilzeth de Luna Freire Pessôa, Marc Loyens, Rachele Piras, Tania Aguirre, Hélène Gras‐Masse, Marc Bossus   +9 more
openalex   +1 more source

Hydrophobin‐Coated Echogenic Microbubbles for Molecular Targeting of Tumor Cells

Advanced Science, EarlyView.
Echogenic microbubbles based on hydrophobin and corresponding fusion protein (HFBI‐domZ) are developed as contrast agents for cancer diagnostics. Hydrophobin provides high stabilization of encapsulated perfluoro‐n‐butane, and fusion proteins allow further versatile functionalization with antibodies. In‐vitro experiments indicate that these microbubbles
Hedar H. Al‐Terke, Grégory Beaune, Muhammad Junaid, Jani Seitsonen, Arja Paananen, Pierangelo Metrangolo, Jaakko V. I. Timonen, Jussi Joensuu, Robin H. A. Ras   +8 more
wiley   +1 more source

Anthrax Protective Antigen Retargeted with Single-Chain Variable Fragments Delivers Enzymes to Pancreatic Cancer Cells. [PDF]

Chembiochem, 2020
Loftis AR, Santos MS, Truex NL, Biancucci M, Satchell KJF, Pentelute BL.   +5 more
europepmc   +1 more source

Relationship between anticapsular antibody and protective activity of a capsular antigen of Haemophilus paragallinarum.

, 1984
Akira SAWATA, Katsumi KUME, Toyotsugu NAKAI   +2 more
openalex   +2 more sources

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Anthrax Protective Antigen 63 (PA63): Toxic Effects in Neural Cultures and Role in Gulf War Illness (GWI). [PDF]

Neurosci Insights, 2020
Tsilibary EC, Souto EP, Kratzke M, James LM, Engdahl BE, Georgopoulos AP.   +5 more
europepmc   +1 more source