Results 11 to 20 of about 9,193,993 (329)
Hierarchical graph learning for protein–protein interaction
Nature Communications, 2023 Despite recent progress, machine learning methods remain inadequate in modeling the natural protein-protein interaction (PPI) hierarchy for PPI prediction.
Ziqi Gao +8 more
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Identification of direct residue contacts in protein-protein interaction by message passing [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2009 Understanding the molecular determinants of specificity in protein-protein interaction is an outstanding challenge of postgenome biology. The availability of large protein databases generated from sequences of hundreds of bacterial genomes enables ...
Altschuh +29 more
core +3 more sources
Nucleic Acids Res., 2022 Much of the complexity within cells arises from functional and regulatory interactions among proteins. The core of these interactions is increasingly known, but novel interactions continue to be discovered, and the information remains scattered across ...
Damian Szklarczyk +12 more
semanticscholar +1 more source
Prediction of protein–protein interaction using graph neural networks
Scientific Reports, 2022 Proteins are the essential biological macromolecules required to perform nearly all biological processes, and cellular functions. Proteins rarely carry out their tasks in isolation but interact with other proteins (known as protein–protein interaction ...
Kanchan Jha, S. Saha, Hiteshi Singh
semanticscholar +1 more source
AlphaPulldown—a python package for protein–protein interaction screens using AlphaFold-Multimer
bioRxiv, 2022 Summary The Artificial Intelligence-based structure prediction program AlphaFold-Multimer enabled structural modelling of protein complexes with unprecedented accuracy.
Dingquan Yu +3 more
semanticscholar +1 more source
Nucleic Acids Res., 2020 Cellular life depends on a complex web of functional associations between biomolecules. Among these associations, protein–protein interactions are particularly important due to their versatility, specificity and adaptability.
Damian Szklarczyk +11 more
semanticscholar +1 more source
A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing
Nature, 2020 A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individuals
D. Gordon +124 more
semanticscholar +1 more source
Calcium in the Backstage of Malaria Parasite Biology
Frontiers in Cellular and Infection Microbiology, 2021 The calcium ion (Ca2+) is a ubiquitous second messenger involved in key biological processes in prokaryotes and eukaryotes. In Plasmodium species, Ca2+ signaling plays a central role in the parasite life cycle.
Lucas Silva de Oliveira +8 more
doaj +1 more source
Mass spectrometry‐based protein–protein interaction networks for the study of human diseases
Molecular Systems Biology, 2021 A better understanding of the molecular mechanisms underlying disease is key for expediting the development of novel therapeutic interventions. Disease mechanisms are often mediated by interactions between proteins. Insights into the physical rewiring of
Alicia L. Richards +2 more
semanticscholar +1 more source
Biochemistry and Biophysics Reports, 2020 Angiotensin II (Ang II) type 2 receptor (AT2R) is one of the major components of the renin-angiotensin-aldosterone system. Nevertheless, the physiological role is not well defined compared to the understanding of the Ang II type 1 receptor (AT1R), which ...
Keita Soda +3 more
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