Results 61 to 70 of about 9,193,993 (329)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Challenges and opportunities in technologies and methods for lncRNA structure determination

Cell & Bioscience
Long non-coding RNAs (lncRNAs) play pivotal roles in diverse cellular processes ranging from gene regulation and chromatin remodeling to RNA stability and epigenetic modifications. Despite the identification of approximately 95,000 lncRNA genes in humans,
Maximilia Frazao De Souza Degenhardt, Yun-Xing Wang   +1 more
doaj   +1 more source

Discover protein sequence signatures from protein-protein interaction data

BMC Bioinformatics, 2005
Background The development of high-throughput technologies such as yeast two-hybrid systems and mass spectrometry technologies has made it possible to generate large protein-protein interaction (PPI) datasets.
Haasl Ryan J, Fang Jianwen, Dong Yinghua, Lushington Gerald H   +3 more
doaj   +1 more source

Two Rules on the Protein-Ligand Interaction [PDF]

, 2008
So far, we still lack a clear molecular mechanism to explain the protein-ligand interaction on the basis of electronic structure of a protein. By combining the calculation of the full electronic structure of a protein along with its hydrophobic pocket ...
Lily Zhang, Lina Xu, Linxiang Zhou, Xiaodong Pang, Xinyi Zhang   +4 more
core   +1 more source

COFACTOR: improved protein function prediction by combining structure, sequence and protein–protein interaction information

Nucleic Acids Res., 2017
The COFACTOR web server is a unified platform for structure-based multiple-level protein function predictions. By structurally threading low-resolution structural models through the BioLiP library, the COFACTOR server infers three categories of protein ...
Chengxin Zhang, P. Freddolino, Yang Zhang   +2 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Deep learning frameworks for protein–protein interaction prediction

Computational and Structural Biotechnology Journal, 2022
Protein-protein interactions (PPIs) play key roles in a broad range of biological processes. The disorder of PPIs often causes various physical and mental diseases, which makes PPIs become the focus of the research on disease mechanism and clinical ...
Xiaotian Hu, Cong Feng, Tianyi Ling, Ming Chen   +3 more
doaj   +1 more source

APID database: redefining protein–protein interaction experimental evidences and binary interactomes

Database J. Biol. Databases Curation, 2019
The collection and integration of all the known protein–protein physical interactions within a proteome framework are critical to allow proper exploration of the protein interaction networks that drive biological processes in cells at molecular level ...
D. Alonso-López, F. Campos-Laborie, Miguel A. Gutiérrez, L. Lambourne, M. Calderwood, M. Vidal, J De Las Rivas   +6 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A bidirectional fluorescent two-hybrid system for monitoring protein–protein interactions

, 2014
Two-hybrid systems have been the cornerstone of research into protein–protein interactions, but these systems typically rely on life/death reporters that put additional selective pressure on the host organism, and potentially lead to false positives ...
Nordgren, Ida Karin, Tavassoli, Ali
core   +1 more source