Results 51 to 60 of about 2,914,082 (253)

STRING and STITCH: known and predicted interactions between proteins and chemicals [PDF]

, 2008
Information on protein-protein and protein-chemical interactions is essential for understanding cellular functions. The STRING and STITCH web resources integrate interaction evidence derived from pathways, automatic literature mining, primary ...
Christian von Mering, Lars J. Jensen, Manuel Stark, Michael Kuhn, Peer Bork, Samuel Chaffron   +5 more
core   +2 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Disposition of Federally Owned Surpluses [PDF]

, 1944
PDZ domains are scaffolding modules in protein-protein interactions that mediate numerous physiological functions by interacting canonically with the C-terminus or non-canonically with an internal motif of protein ligands. A conserved carboxylate-binding
A Bach, A Bach, A Bach, BA Appleton, BH Chang, BJ Hillier, BZ Harris, CN Chi, CN Chi, CN Chi, DA Doyle, E Chapman, E Kim, E Kim, ET Powers, FI Valiyaveetil, G Hultqvist, GM Elias, GS Beligere, H Remaut, H Tochio, H Tochio, HJ Lee, J Schultz, J Schultz, JA Wells, JF Amacher, JNN Eildal, JT Andreasen, JT Koh, KK Dev, KS Bateman, L Funke, M Aarts, M Sheng, M Vila-Perelló, MA Stiffler, MD Hill, MR Arkin, N Calosci, NX Wang, OA Karlsson, R Tonikian, RN McLaughlin Jr., S Deechongkit, S Seedorff, SH Gee, TW Muir, W Feng, Y Zhang, Z Songyang   +50 more
core   +2 more sources

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

Spatiotemporal binding of cyclophilin A and CPSF6 to capsid regulates HIV-1 nuclear entry and integration

mBio
Human immunodeficiency virus type 1 (HIV-1) capsid, which is the target of the antiviral lenacapavir, protects the viral genome and binds multiple host proteins to influence intracellular trafficking, nuclear import, and integration.
Zachary Ingram, Christopher Kline, Alexandra K. Hughson, Parmit K. Singh, Hannah L. Fischer, Rajalingham Radhakrishnan, Gregory A. Sowd, Nayara F. B. Dos Santos, Barbie K. Ganser-Pornillos, Simon C. Watkins, Melissa Kane, Alan N. Engelman, Zandrea Ambrose   +12 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Poly-Sarcosine and Poly(ethylene-glycol) interactions with proteins investigated using molecular dynamics simulations [PDF]

, 2018
Nanoparticles coated with hydrophilic polymers often show a reduction in unspecific interactions with the biological environment, which improves their biocompatibility.
Barz, Matthias, Muhl, Christian, Schmid, Friederike, Schäfer, Timo, Settanni, Giovanni   +4 more
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

USP15 regulates dynamic protein-protein interactions of the spliceosome through deubiquitination of PRP31. [PDF]

, 2017
Post-translational modifications contribute to the spliceosome dynamics by facilitating the physical rearrangements of the spliceosome. Here, we report USP15, a deubiquitinating enzyme, as a regulator of protein-protein interactions for the spliceosome ...
Das, Tanuza, Kim, Eunice EunKyeong, Kim, Eunji, Park, Jinyoung, Park, Joon Kyu, Rape, Michael, Song, Eun Joo   +6 more
core   +1 more source