Results 41 to 50 of about 7,742,815 (253)

Hyperglycemia attenuates fibroblast contractility via suppression of TβRII receptor modulated α-smooth muscle actin expression

Biotechnology & Biotechnological Equipment, 2022
Nonhealing wounds are a common complication in patients suffering from diabetes with hyperglycemia being the most deteriorating factor for this serious pathological condition. Despite the great body of data, the molecular mechanisms by which high glucose
Alexandar Evangelatov, Georgi Georgiev, Borislav Arabadjiev, Stefan Pankov, Plamen Krastev, Albena Momchilova, Roumen Pankov   +6 more
doaj   +1 more source

Additional file 15: Table S2. of A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of proteinâ protein interactions identifies a novel putative Mdm2-binding site in p53

, 2017
List of yeast strains used in the study. (PDF 111 kb)
Wong, Jin, Alfatah, Mohammad, Sin, Mei, Sim, Hong, Verma, Chandra, Lane, David, Arumugam, Prakash   +6 more
openaire   +1 more source

PEPscan: A Broad Spectrum Approach for the Characterization of Protein-Binder Interactions?

Biomolecules, 2022
In a previous study, we have shown that PEPscan can provide a cheap and rapid means to identify candidate interfering peptides (IPs), i.e., peptides able to disrupt a target protein-protein interaction.
Angelita Rebollo, Louise Fliedel, Pierre Tuffery   +2 more
doaj   +1 more source

Quenching protein dynamics interferes with HIV capsid maturation

Nature Communications, 2017
The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to ...
Mingzhang Wang, Caitlin M. Quinn, Juan R. Perilla, Huilan Zhang, Randall Shirra Jr., Guangjin Hou, In-Ja Byeon, Christopher L. Suiter, Sherimay Ablan, Emiko Urano, Theodore J. Nitz, Christopher Aiken, Eric O. Freed, Peijun Zhang, Klaus Schulten, Angela M. Gronenborn, Tatyana Polenova   +16 more
doaj   +1 more source

Protein–Protein Interactions in Translesion Synthesis

Molecules, 2021
Translesion synthesis (TLS) is an error-prone DNA damage tolerance mechanism used by actively replicating cells to copy past DNA lesions and extend the primer strand.
Radha Charan Dash, Kyle Hadden
doaj   +1 more source

One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells

Scientific Reports, 2017
Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected ...
Wei Li, Yanling Wu, Desheng Kong, Hongjia Yang, Yanping Wang, Jiping Shao, Yang Feng, Weizao Chen, Liying Ma, Tianlei Ying, Dimiter S. Dimitrov   +10 more
doaj   +1 more source

Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid

Molecules, 2017
Circulating heptadecanoic acid (C17:0) is reported to be a pathology risk/prognosis biomarker and a dietary biomarker. This pathology relationship has been shown to be reliably predictive even when independent of dietary contributions, suggesting that ...
Benjamin Jenkins, Evelyn de Schryver, Paul P. Van Veldhoven, Albert Koulman   +3 more
doaj   +1 more source

Aromatic clusters in protein–protein and protein–drug complexes

Journal of Cheminformatics, 2020
Aromatic rings are important residues for biological interactions and appear to a large extent as part of protein–drug and protein–protein interactions. They are relevant for both protein stability and molecular recognition processes due to their natural
Esteban Lanzarotti, Lucas A. Defelipe, Marcelo A. Marti, Adrián G. Turjanski   +3 more
doaj   +1 more source

Additional file 14: Table S1. of A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of proteinâ protein interactions identifies a novel putative Mdm2-binding site in p53

, 2017
List of plasmids used in the study. (PDF 66 kb)
Wong, Jin, Alfatah, Mohammad, Sin, Mei, Sim, Hong, Verma, Chandra, Lane, David, Arumugam, Prakash   +6 more
openaire   +1 more source

Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site

Nature Communications, 2016
The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid that ...
Chuang Liu, Juan R. Perilla, Jiying Ning, Manman Lu, Guangjin Hou, Ruben Ramalho, Benjamin A. Himes, Gongpu Zhao, Gregory J. Bedwell, In-Ja Byeon, Jinwoo Ahn, Angela M. Gronenborn, Peter E. Prevelige, Itay Rousso, Christopher Aiken, Tatyana Polenova, Klaus Schulten, Peijun Zhang   +17 more
doaj   +1 more source