Results 31 to 40 of about 7,742,815 (253)

Conjugates of Small Molecule Drugs with Antibodies and Other Proteins

Biomedicines, 2014
Conjugates of small molecule drugs with antibodies (ADCs) and with other proteins (protein-drug conjugates, PDC) are used as a new class of targeted therapeutics combining the specificity of monoclonal antibodies (mAbs) and other proteins with potent ...
Yang Feng, Zhongyu Zhu, Weizao Chen, Ponraj Prabakaran, Kedan Lin, Dimiter S. Dimitrov   +5 more
doaj   +1 more source

Prediction of protein-protein interaction types using association rule based classification [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Park et alBackground: Protein-protein interactions (PPI) can be classified according to their characteristics into, for example obligate or transient ...
José A Reyes, Kim, JW, Kim, S, Kim Ji, Sangsoo Kim, Gilbert, D, Park, SH, Reyes José A, Reyes, JA, Kim Sangsoo, Park Sung, Ji Kim, David R Gilbert, Gilbert David R, Sung Park   +14 more
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CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
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High Impact: The Role of Promiscuous Binding Sites in Polypharmacology

Molecules, 2019
The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology.
Natacha Cerisier, Michel Petitjean, Leslie Regad, Quentin Bayard, Manon Réau, Anne Badel, Anne-Claude Camproux   +6 more
doaj   +1 more source

A script to highlight hydrophobicity and charge on protein surfaces [PDF]

, 2015
The composition of protein surfaces determines both affinity and specificity of protein-protein interactions. Matching of hydrophobic contacts and charged groups on both sites of the interface are crucial to ensure specificity.
Tania eMorán Luengo, Stefan G. D. Rüdiger, Dominique Hagemans, Cellular Protein Chemistry, Ianthe A. E. M. van Belzen, Ianthe A.E.M. van Belzen, van Belzen, Ianthe A E M, Sub Cellular Protein Chemistry, Morán Luengo, Tania, Rüdiger, Stefan G D, Tania Morán Luengo, Dominique eHagemans, Hagemans, Dominique   +12 more
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Contextualized Protein-Protein Interactions

Patterns, 2021
Summary: Protein-protein interaction (PPI) databases are an important bioinformatics resource, yet existing literature-curated databases usually represent cell-type-agnostic interactions, which is at variance with our understanding that protein dynamics ...
Anthony Federico, Stefano Monti
doaj   +1 more source

Chapter 1. Identification of Cellular Protein–Protein Interactions

, 2020
There are myriad interactions between proteins in the cell. The diversity and dynamics of the interactions make them challenging to chart, and a large variety of methods have been developed to tackle the task.
Sara Bergström Lind, Elias Tjärnhage, Tjärnhage, Elias,, Eszter Kassa, Kassa, Eszter,, Ivarsson, Ylva,, Benz, Caroline,, Bergström Lind, Sara,, Caroline Benz, Ylva Ivarsson   +9 more
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Interaction of two strongly divergent archaellins stabilizes the structure of the Halorubrum archaellum

MicrobiologyOpen, 2020
Halophilic archaea from the genus Halorubrum possess two extraordinarily diverged archaellin genes, flaB1 and flaB2. To clarify roles for each archaellin, we compared two natural Halorubrum lacusprofundi strains: One of them contains both archaellin ...
Mikhail G. Pyatibratov, Alexey S. Syutkin, Tessa E. F. Quax, Tatjana N. Melnik, R. Thane Papke, Johann Peter Gogarten, Igor I. Kireev, Alexey K. Surin, Sergei N. Beznosov, Anna V. Galeva, Oleg V. Fedorov   +10 more
doaj   +1 more source

A time-resolved multi-omics atlas of Acanthamoeba castellanii encystment

Nature Communications, 2022
Encystment is a process that allows free-living and parasitic amoebae to survive in unfavorable environments. Here, Bernard et al. provide detailed insights into the early stages of encystment of Acanthamoeba castellanii by integrating RNA-Seq ...
Clément Bernard, Marie Locard-Paulet, Cyril Noël, Magalie Duchateau, Quentin Giai Gianetto, Bouziane Moumen, Thomas Rattei, Yann Hechard, Lars Juhl Jensen, Mariette Matondo, Ascel Samba-Louaka   +10 more
doaj   +1 more source

Computational Protein Design Force Field Optimization: A Negative Design Approach [PDF]

, 2007
An accurate force field is essential to computational protein design and protein folding studies. Proper force field tuning is problematic, however, due in part to the incomplete modeling of the unfolded state.
Alvizo, Oscar
core   +1 more source