Results 31 to 40 of about 2,914,082 (253)

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. [PDF]

, 2015
The current knowledge on how transcription factors (TFs), the ultimate targets and executors of cellular signalling pathways, are regulated by protein-protein interactions remains limited.
Anna Malovannaya, David H Hawke, Jiadong Wang, Jun Qin, Junjie Chen, Kaestner KH, Rudy Guerra, Wei Li, Wenqi Wang, Xu Li, Yuanxin Xi   +10 more
core   +2 more sources

Length, Protein-Protein Interactions, and Complexity

, 2004
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear.
Albert, Bateman, Bates, Bates, Boeckmann, Carlson, Daan Frenkel, Eisenhaber, Hasty, Hopkins, Jeong, Jeong, Lander, Mewes, Michael W. Deem, Mott, Prost, Rhines, Riddle, Steinmetz, Strausberg, Taison Tan, Uetz, Vishal Gupta, Watts, Waxman, Zhang, Zhang   +27 more
core   +1 more source

Homologous Recombination under the Single-Molecule Fluorescence Microscope [PDF]

, 2019
Homologous recombination (HR) is a complex biological process and is central to meiosis and for repair of DNA double-strand breaks. Although the HR process has been the subject of intensive study for more than three decades, the complex protein–protein ...
Dhakal, Soma, Gibbs, Dalton R.
core   +2 more sources

One-domain CD4 Fused to Human Anti-CD16 Antibody Domain Mediates Effective Killing of HIV-1-Infected Cells

Scientific Reports, 2017
Bispecific killer cells engagers (BiKEs) which can bind to natural killer (NK) cells through the activating receptor CD16A and guide them to cells expressing the HIV-1 envelope glycoprotein (Env) are a promising new weapon for elimination of infected ...
Wei Li, Yanling Wu, Desheng Kong, Hongjia Yang, Yanping Wang, Jiping Shao, Yang Feng, Weizao Chen, Liying Ma, Tianlei Ying, Dimiter S. Dimitrov   +10 more
doaj   +1 more source

Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid

Molecules, 2017
Circulating heptadecanoic acid (C17:0) is reported to be a pathology risk/prognosis biomarker and a dietary biomarker. This pathology relationship has been shown to be reliably predictive even when independent of dietary contributions, suggesting that ...
Benjamin Jenkins, Evelyn de Schryver, Paul P. Van Veldhoven, Albert Koulman   +3 more
doaj   +1 more source

Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice [PDF]

, 2018
Elevated N-methyl-D-aspartate receptor (NMDAR) activity is linked to central sensitization and chronic pain. However, NMDAR antagonists display limited therapeutic potential because of their adverse side effects. Novel approaches targeting the NR2B-PSD95-
Chawla, Aarti, Courtney, Michael J., Hohmann, Andrea G., Hudmon, Andy, Lai, Yvonne Y., Lee, Wan-Hung, Li, Li-Li   +6 more
core   +1 more source

Aromatic clusters in protein–protein and protein–drug complexes

Journal of Cheminformatics, 2020
Aromatic rings are important residues for biological interactions and appear to a large extent as part of protein–drug and protein–protein interactions. They are relevant for both protein stability and molecular recognition processes due to their natural
Esteban Lanzarotti, Lucas A. Defelipe, Marcelo A. Marti, Adrián G. Turjanski   +3 more
doaj   +1 more source

Additional file 15: Table S2. of A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of proteinâ protein interactions identifies a novel putative Mdm2-binding site in p53

, 2017
List of yeast strains used in the study. (PDF 111 kb)
Wong, Jin, Alfatah, Mohammad, Sin, Mei, Sim, Hong, Verma, Chandra, Lane, David, Arumugam, Prakash   +6 more
openaire   +1 more source

Structural Prediction of Protein–Protein Interactions by Docking: Application to Biomedical Problems [PDF]

, 2018
A huge amount of genetic information is available thanks to the recent advances in sequencing technologies and the larger computational capabilities, but the interpretation of such genetic data at phenotypic level remains elusive.
Barradas-Bautista, Didier, Fernández-Recio, Juan, Pallara, Chiara, Rosell, Mireia   +3 more
core   +2 more sources

Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site

Nature Communications, 2016
The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid that ...
Chuang Liu, Juan R. Perilla, Jiying Ning, Manman Lu, Guangjin Hou, Ruben Ramalho, Benjamin A. Himes, Gongpu Zhao, Gregory J. Bedwell, In-Ja Byeon, Jinwoo Ahn, Angela M. Gronenborn, Peter E. Prevelige, Itay Rousso, Christopher Aiken, Tatyana Polenova, Klaus Schulten, Peijun Zhang   +17 more
doaj   +1 more source