Results 21 to 30 of about 2,914,082 (253)
High Impact: The Role of Promiscuous Binding Sites in Polypharmacology
Molecules, 2019 The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology.
Natacha Cerisier +6 more
doaj +1 more source
A time-resolved multi-omics atlas of Acanthamoeba castellanii encystment
Nature Communications, 2022 Encystment is a process that allows free-living and parasitic amoebae to survive in unfavorable environments. Here, Bernard et al. provide detailed insights into the early stages of encystment of Acanthamoeba castellanii by integrating RNA-Seq ...
Clément Bernard +10 more
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Contextualized Protein-Protein Interactions
Patterns, 2021 Summary: Protein-protein interaction (PPI) databases are an important bioinformatics resource, yet existing literature-curated databases usually represent cell-type-agnostic interactions, which is at variance with our understanding that protein dynamics ...
Anthony Federico, Stefano Monti
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MicrobiologyOpen, 2020 Halophilic archaea from the genus Halorubrum possess two extraordinarily diverged archaellin genes, flaB1 and flaB2. To clarify roles for each archaellin, we compared two natural Halorubrum lacusprofundi strains: One of them contains both archaellin ...
Mikhail G. Pyatibratov +10 more
doaj +1 more source
Bigraphical models for protein and membrane interactions [PDF]
, 2009 We present a bigraphical framework suited for modeling biological systems both at protein level and at membrane level. We characterize formally bigraphs corresponding to biologically meaningful systems, and bigraphic rewriting rules representing ...
Davide Grohmann +3 more
core +5 more sources
Biotechnology & Biotechnological Equipment, 2022 Nonhealing wounds are a common complication in patients suffering from diabetes with hyperglycemia being the most deteriorating factor for this serious pathological condition. Despite the great body of data, the molecular mechanisms by which high glucose
Alexandar Evangelatov +6 more
doaj +1 more source
Elucidating glycosaminoglycan–protein–protein interactions using carbohydrate microarray and computational approaches [PDF]
, 2011 Glycosaminoglycan polysaccharides play critical roles in many cellular processes, ranging from viral invasion and angiogenesis to spinal cord injury.
Bothwell +39 more
core +2 more sources
PEPscan: A Broad Spectrum Approach for the Characterization of Protein-Binder Interactions?
Biomolecules, 2022 In a previous study, we have shown that PEPscan can provide a cheap and rapid means to identify candidate interfering peptides (IPs), i.e., peptides able to disrupt a target protein-protein interaction.
Angelita Rebollo +2 more
doaj +1 more source
Quenching protein dynamics interferes with HIV capsid maturation
Nature Communications, 2017 The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to ...
Mingzhang Wang +16 more
doaj +1 more source
Protein–Protein Interactions in Translesion Synthesis
Molecules, 2021 Translesion synthesis (TLS) is an error-prone DNA damage tolerance mechanism used by actively replicating cells to copy past DNA lesions and extend the primer strand.
Radha Charan Dash, Kyle Hadden
doaj +1 more source