Results 21 to 30 of about 1,961,222 (270)
Determination of Histidine Protonation States in Proteins by Fast Magic Angle Spinning NMR
Frontiers in Molecular Biosciences, 2021 Histidine residues play important structural and functional roles in proteins, such as serving as metal-binding ligands, mediating enzyme catalysis, and modulating proton channel activity. Many of these activities are modulated by the ionization state of
Roman Zadorozhnyi +11 more
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Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding [PDF]
PeerJ, 2018 The structure-thermodynamics correlation analysis was performed for a series of fluorine- and chlorine-substituted benzenesulfonamide inhibitors binding to several human carbonic anhydrase (CA) isoforms.
Alexey Smirnov +4 more
doaj +2 more sources
Competing transfer pathways in direct and indirect dynamic nuclear polarization magic anglespinning nuclear magnetic resonance experiments on HIV-1 capsid assemblies: implications for sensitivity and resolution [PDF]
Magnetic Resonance, 2021 Dynamic nuclear polarization (DNP)-enhanced magic angle spinning (MAS) nuclear magnetic resonance (NMR) of biological systems is a rapidly growing field.
I. V. Sergeyev +6 more
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Antibody Aggregation: Insights from Sequence and Structure
Antibodies, 2016 Monoclonal antibodies (mAbs) are the fastest-growing biological therapeutics with important applications ranging from cancers, autoimmunity diseases and metabolic disorders to emerging infectious diseases.
Wei Li +5 more
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Nature Communications, 2022 SHP2 is an important human tyrosine phosphatase with key roles in cancer, immune responses and insulin signaling. Here, the authors explore its substrate recognition mechanism in molecular detail and uncover a complex regulatory mechanism for this enzyme
András Zeke +9 more
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Conjugates of Small Molecule Drugs with Antibodies and Other Proteins
Biomedicines, 2014 Conjugates of small molecule drugs with antibodies (ADCs) and with other proteins (protein-drug conjugates, PDC) are used as a new class of targeted therapeutics combining the specificity of monoclonal antibodies (mAbs) and other proteins with potent ...
Yang Feng +5 more
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High Impact: The Role of Promiscuous Binding Sites in Polypharmacology
Molecules, 2019 The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology.
Natacha Cerisier +6 more
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Contextualized Protein-Protein Interactions
Patterns, 2021 Summary: Protein-protein interaction (PPI) databases are an important bioinformatics resource, yet existing literature-curated databases usually represent cell-type-agnostic interactions, which is at variance with our understanding that protein dynamics ...
Anthony Federico, Stefano Monti
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Chapter 1. Identification of Cellular Protein–Protein Interactions
, 2020 There are myriad interactions between proteins in the cell. The diversity and dynamics of the interactions make them challenging to chart, and a large variety of methods have been developed to tackle the task.
Sara Bergström Lind +9 more
core +1 more source
MicrobiologyOpen, 2020 Halophilic archaea from the genus Halorubrum possess two extraordinarily diverged archaellin genes, flaB1 and flaB2. To clarify roles for each archaellin, we compared two natural Halorubrum lacusprofundi strains: One of them contains both archaellin ...
Mikhail G. Pyatibratov +10 more
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