Results 21 to 30 of about 7,742,815 (253)

Developing a peptide to disrupt cohesin head domain interactions

iScience, 2023
Summary: Cohesin mediates the 3-D structure of chromatin and is involved in maintaining genome stability and function. The cohesin core comprises Smc1 and Smc3, elongated-shaped proteins that dimerize through globular domains at their edges, called head ...
Maria Elias, Samar Gani, Yana Lerner, Katreen Yamin, Chen Tor, Adarsh Patel, Avi Matityahu, Moshe Dessau, Nir Qvit, Itay Onn   +9 more
doaj   +1 more source

Quercetin affects membrane lipids and apoptosis in three-dimensional fibroblast cultures

Biotechnology & Biotechnological Equipment, 2021
The polyphenol quercetin is associated with numerous beneficial health effects in various pathologies such as oxidative stress, neurodegenerative disorders, inflammation, neoplastic processes, age-related diseases, and so on.
Albena Momchilova, Tania Markovska, Georgi Georgiev, Stefan Pankov, Galya Staneva, Diana Petkova, Plamen Krastev, Adriana Pinkas, Roumen Pankov   +8 more
doaj   +1 more source

Determination of Histidine Protonation States in Proteins by Fast Magic Angle Spinning NMR

Frontiers in Molecular Biosciences, 2021
Histidine residues play important structural and functional roles in proteins, such as serving as metal-binding ligands, mediating enzyme catalysis, and modulating proton channel activity. Many of these activities are modulated by the ionization state of
Roman Zadorozhnyi, Roman Zadorozhnyi, Sucharita Sarkar, Sucharita Sarkar, Caitlin M. Quinn, Kaneil K. Zadrozny, Barbie K. Ganser-Pornillos, Owen Pornillos, Angela M. Gronenborn, Angela M. Gronenborn, Tatyana Polenova, Tatyana Polenova   +11 more
doaj   +1 more source

Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding [PDF]

PeerJ, 2018
The structure-thermodynamics correlation analysis was performed for a series of fluorine- and chlorine-substituted benzenesulfonamide inhibitors binding to several human carbonic anhydrase (CA) isoforms.
Alexey Smirnov, Asta Zubrienė, Elena Manakova, Saulius Gražulis, Daumantas Matulis   +4 more
doaj   +2 more sources

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source

Competing transfer pathways in direct and indirect dynamic nuclear polarization magic anglespinning nuclear magnetic resonance experiments on HIV-1 capsid assemblies: implications for sensitivity and resolution [PDF]

Magnetic Resonance, 2021
Dynamic nuclear polarization (DNP)-enhanced magic angle spinning (MAS) nuclear magnetic resonance (NMR) of biological systems is a rapidly growing field.
I. V. Sergeyev, C. M. Quinn, J. Struppe, A. M. Gronenborn, A. M. Gronenborn, T. Polenova, T. Polenova   +6 more
doaj   +1 more source

Analysis of leukocyte membrane protein interactions using protein microarrays [PDF]

, 2005
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
Foster-Cuevas, M, Letarte, Michelle, Deborah Hatherley, Foster-Cuevas, Mildred, Hatherley, D, Barclay, AN, Michelle Letarte, Saunders, Nigel, A Neil Barclay, Saunders, NJ, Hatherley, Deborah, Letarte, M, Barclay, Neil, Mildred Foster-Cuevas, Nigel J Saunders, Saunders, Nigel J, Voulgaraki, D, Despina Voulgaraki, Voulgaraki, Despina   +18 more
core   +1 more source

Antibody Aggregation: Insights from Sequence and Structure

Antibodies, 2016
Monoclonal antibodies (mAbs) are the fastest-growing biological therapeutics with important applications ranging from cancers, autoimmunity diseases and metabolic disorders to emerging infectious diseases.
Wei Li, Ponraj Prabakaran, Weizao Chen, Zhongyu Zhu, Yang Feng, Dimiter S. Dimitrov   +5 more
doaj   +1 more source

Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling

Nature Communications, 2022
SHP2 is an important human tyrosine phosphatase with key roles in cancer, immune responses and insulin signaling. Here, the authors explore its substrate recognition mechanism in molecular detail and uncover a complex regulatory mechanism for this enzyme 
András Zeke, Tamás Takács, Péter Sok, Krisztina Németh, Klára Kirsch, Péter Egri, Ádám Levente Póti, Isabel Bento, Gábor E. Tusnády, Attila Reményi   +9 more
doaj   +1 more source

ProDGe: investigating protein-protein interactions at the domain level [PDF]

, 2011
An important goal of systems biology is the identification and investigation of known and predicted protein-protein interactions to obtain more information about new cellular pathways and processes.
Andreas Dräger, Clemens Wrzodek, Adrian Schröder, Adrian Schröder, Florian Mittag, Andreas Zell, Finja Büchel, Andreas Dräger, Finja Büchel   +8 more
core   +1 more source