Results 11 to 20 of about 2,914,082 (253)

Determination of Histidine Protonation States in Proteins by Fast Magic Angle Spinning NMR

Frontiers in Molecular Biosciences, 2021
Histidine residues play important structural and functional roles in proteins, such as serving as metal-binding ligands, mediating enzyme catalysis, and modulating proton channel activity. Many of these activities are modulated by the ionization state of
Roman Zadorozhnyi, Roman Zadorozhnyi, Sucharita Sarkar, Sucharita Sarkar, Caitlin M. Quinn, Kaneil K. Zadrozny, Barbie K. Ganser-Pornillos, Owen Pornillos, Angela M. Gronenborn, Angela M. Gronenborn, Tatyana Polenova, Tatyana Polenova   +11 more
doaj   +1 more source

Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding [PDF]

PeerJ, 2018
The structure-thermodynamics correlation analysis was performed for a series of fluorine- and chlorine-substituted benzenesulfonamide inhibitors binding to several human carbonic anhydrase (CA) isoforms.
Alexey Smirnov, Asta Zubrienė, Elena Manakova, Saulius Gražulis, Daumantas Matulis   +4 more
doaj   +2 more sources

Competing transfer pathways in direct and indirect dynamic nuclear polarization magic anglespinning nuclear magnetic resonance experiments on HIV-1 capsid assemblies: implications for sensitivity and resolution [PDF]

Magnetic Resonance, 2021
Dynamic nuclear polarization (DNP)-enhanced magic angle spinning (MAS) nuclear magnetic resonance (NMR) of biological systems is a rapidly growing field.
I. V. Sergeyev, C. M. Quinn, J. Struppe, A. M. Gronenborn, A. M. Gronenborn, T. Polenova, T. Polenova   +6 more
doaj   +1 more source

ProDGe: investigating protein-protein interactions at the domain level [PDF]

, 2011
An important goal of systems biology is the identification and investigation of known and predicted protein-protein interactions to obtain more information about new cellular pathways and processes.
Adrian Schrö, Andreas Drä, Andreas Zell, Clemens Wrzodek, Finja Bü, Florian Mittag   +5 more
core   +2 more sources

Antibody Aggregation: Insights from Sequence and Structure

Antibodies, 2016
Monoclonal antibodies (mAbs) are the fastest-growing biological therapeutics with important applications ranging from cancers, autoimmunity diseases and metabolic disorders to emerging infectious diseases.
Wei Li, Ponraj Prabakaran, Weizao Chen, Zhongyu Zhu, Yang Feng, Dimiter S. Dimitrov   +5 more
doaj   +1 more source

Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling

Nature Communications, 2022
SHP2 is an important human tyrosine phosphatase with key roles in cancer, immune responses and insulin signaling. Here, the authors explore its substrate recognition mechanism in molecular detail and uncover a complex regulatory mechanism for this enzyme 
András Zeke, Tamás Takács, Péter Sok, Krisztina Németh, Klára Kirsch, Péter Egri, Ádám Levente Póti, Isabel Bento, Gábor E. Tusnády, Attila Reményi   +9 more
doaj   +1 more source

Hot-spot analysis for drug discovery targeting protein-protein interactions [PDF]

, 2018
Introduction: Protein-protein interactions are important for biological processes and pathological situations, and are attractive targets for drug discovery. However, rational drug design targeting protein-protein interactions is still highly challenging.
Fernández-Recio, Juan, Rosell, Mireia
core   +2 more sources

Conjugates of Small Molecule Drugs with Antibodies and Other Proteins

Biomedicines, 2014
Conjugates of small molecule drugs with antibodies (ADCs) and with other proteins (protein-drug conjugates, PDC) are used as a new class of targeted therapeutics combining the specificity of monoclonal antibodies (mAbs) and other proteins with potent ...
Yang Feng, Zhongyu Zhu, Weizao Chen, Ponraj Prabakaran, Kedan Lin, Dimiter S. Dimitrov   +5 more
doaj   +1 more source

Protein-carbohydrate interactions during fertilization [PDF]

, 1998
Interaction between gametes during fertilization is at least in part regulated by carbohydrate moieties of the zona pellucida (ZP) and carbohydrate binding proteins of the sperm surface. This review focuses on the protein-carbohydrate interactions during
Kolle, S., Plendl, J., Sinowatz, Fred
core   +1 more source

Selective and potent proteomimetic inhibitors of intracellular protein–protein interactions [PDF]

, 2015
Inhibition of protein–protein interactions (PPIs) represents a major challenge in chemical biology and drug discovery. α-Helix mediated PPIs may be amenable to modulation using generic chemotypes, termed “proteomimetics”, which can be assembled in a ...
Azzarito, Barnard, Barth, Berg, Bieging, Borner, Bruncko, Bullock, Burslem, Campbell, Cao, Cheloha, Chipuk, González-Bulnes, Grigoryev, Guichard, Harker, Hoe, Kazi, Kussie, Lao, Lao, Lee, Liu, Long, Mathew, Milroy, Moldoveanu, Moran, Nevola, Oh, Orner, Pan, Saraogi, Saraogi, Schuler, Schäfer, Scott, Shangary, Spiegel, Stumpf, Thornberry, Uhrinova, Vassilev, Vu, Wade, Wells, Yao, Yin, Yin, Zhang, Zhang   +51 more
core   +4 more sources