Results 11 to 20 of about 1,854,416 (221)
Methods for detecting protein-protein interactions [PDF]
Molecules and Cells: Protein-protein interaction (PPI) is central to all cellular processes and play critical roles in both normal physiology and disease pathogenesis. In this brief guide, we outline the fundamental principles and widely used methods for PPI detection ...
Seok Chan Cho, Hyun Woo Park
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Progress and Prospects in FRET for the Investigation of Protein–Protein Interactions [PDF]
BiosensorsProtein–protein interactions (PPIs) play a crucial role in various biological processes, including signal transduction, transcriptional regulation, and metabolic pathways.
Yue Zhang +4 more
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Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A
Nature Communications, 2021 Vpr is a HIV-1 accessory virulence factor that also interacts with the human DNA repair protein hHR23A. Here, the authors present the structure of Vpr in complex with the C-terminal half of hHR23A comprising the XPC-binding and ubiquitin-associated ...
In-Ja L. Byeon +11 more
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Scientific Reports, 2021 Targeted DNA methylation is a technique that aims to methylate cytosines in selected genomic loci. In the most widely used approach a CG-specific DNA methyltransferase (MTase) is fused to a sequence specific DNA binding protein, which binds in the ...
Krystyna Ślaska-Kiss +6 more
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Anti-cancer effect of Petasites hybridus L. (Butterbur) root extract on breast cancer cell lines
Biotechnology & Biotechnological Equipment, 2021 In this study, we present initial data for the potential anti-cancer effects of standardized Bulgarian Petasites hybridus root extract against breast cancer cells. The results showed that Butterbur extract (BE) caused a dose-dependent selective reduction
Rumiana Tzoneva +6 more
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HIV-1 Vpr activates host CRL4-DCAF1 E3 ligase to degrade histone deacetylase SIRT7
Virology Journal, 2021 Background Vpr is a virion-associated protein that is encoded by lentiviruses and serves to counteract intrinsic immunity factors that restrict infection.
Xiaohong Zhou +3 more
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Comparing human–Salmonella with plant–Salmonella protein–protein interaction predictions [PDF]
Frontiers in Microbiology, 2015 Salmonellosis is the most frequent foodborne disease worldwide and can be transmitted to humans by a variety of routes, especially via animal and plant products. Salmonella bacteria are believed to use not only animal and human but also plant hosts despite their evolutionary distance. This raises the question if Salmonella employs similar mechanisms in
Sylvia eSchleker +3 more
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Developing a peptide to disrupt cohesin head domain interactions
iScience, 2023 Summary: Cohesin mediates the 3-D structure of chromatin and is involved in maintaining genome stability and function. The cohesin core comprises Smc1 and Smc3, elongated-shaped proteins that dimerize through globular domains at their edges, called head ...
Maria Elias +9 more
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Quercetin affects membrane lipids and apoptosis in three-dimensional fibroblast cultures
Biotechnology & Biotechnological Equipment, 2021 The polyphenol quercetin is associated with numerous beneficial health effects in various pathologies such as oxidative stress, neurodegenerative disorders, inflammation, neoplastic processes, age-related diseases, and so on.
Albena Momchilova +8 more
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Determination of Histidine Protonation States in Proteins by Fast Magic Angle Spinning NMR
Frontiers in Molecular Biosciences, 2021 Histidine residues play important structural and functional roles in proteins, such as serving as metal-binding ligands, mediating enzyme catalysis, and modulating proton channel activity. Many of these activities are modulated by the ionization state of
Roman Zadorozhnyi +11 more
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