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Clinical significance of citrullinated glial fibrillary acidic protein in predicting outcomes in hepatocellular carcinoma. [PDF]
World J Gastrointest OncolCho YA +9 more
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Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis
Bioorganic and Medicinal Chemistry, 2017Protein arginine deiminases (PAD) are implicated in a variety of inflammatory and neurodegenerative diseases including multiple sclerosis (MS). Following the discovery of an in silico hit containing hydantoin and a piperidine moiety, we hypothesized that a 2-carbon linker on the hydantoin would be necessary for a 5-membered heterocycle for optimal PAD ...
Andrew V Caprariello +2 more
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The Clinical and Prognostic Significance of Protein Arginine Deiminases 2 and 4 in Colorectal Cancer
Pathobiology, 2021<b><i>Introduction:</i></b> Protein arginine deiminases (PADIs) are a family of enzymes that catalyse the post-translational modification of proteins. Association between PADI expression and clinicopathology, protein expression, and outcome was determined. <b><i>Methods:</i></b> PADI2 and PADI4 expression
Mohamed, Gijon +4 more
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Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases
Bioorganic and Medicinal Chemistry, 2015 Agmatine deiminases (AgDs) catalyze the hydrolytic conversion of agmatine (decarboxylated arginine) to N-carbamoylputrescine with concomitant release of ammonia.
Bryan Knuckley, Terri Ellis
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Development of the Protein Arginine Deiminase (PAD) Inhibitors
2017The protein arginine deiminases (PADs) catalyze the hydrolysis of positively charged arginine residues to generate neutral citrulline. This reaction is a calciumdependent process wherein calcium binding triggers a conformational change that results in a >10,000-fold increase in activity (Liu et al. 2011; Kearney et al. 2005).
Aaron Muth, Paul R. Thompson
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Evaluation of protein arginine deiminase-4 inhibitor in TNBS- induced colitis in mice
International Immunopharmacology, 2020Many evidences indicated that neutrophil extracellular traps (NETs) are involved in the pathogenesis of inflammatory bowel disease (IBD). Citrullination of histones by Protein Arginine Deiminase-4 (PAD4) is central for NETs formation. This paper aimed to explore the definite role of NETs in mouse model of Crohn's disease (CD) with 2,4,6-trinitrobenzene
Tingting, Zhang +5 more
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Theoretical investigation of the catalytic mechanism of the protein arginine deiminase 4 enzyme
Theoretical Chemistry Accounts, 2008The mechanism of the transcriptional coregulator protein arginine deiminase 4 (PAD4) in catalyzing the calcium-dependent conversion of specific arginine residues to citrulline and ammonia, was studied in the framework of density functional theory using the hybrid B3LYP exchange correlation potential and a medium-large basis set.
TOSCANO, Marirosa +2 more
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Specificity and mode of action of the muscle-type protein-arginine deiminase
Archives of Biochemistry and Biophysics, 1992The primary and secondary specificities and mode of action of the muscle-type protein-arginine deiminase (PAD) were investigated using various derivatives of Arg and its homologues, as well as Arg-containing peptides by quantitative analyses of the reaction products on reverse-phase HPLC.
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