Results 181 to 190 of about 15,339 (215)

Protein-bound uremic toxins: a long overlooked culprit in cardiorenal syndrome

American Journal of Physiology-Renal Physiology, 2016
Protein-bound uremic toxins (PBUTs) accumulate once renal excretory function declines and are not cleared by dialysis. There is increasing evidence that PBUTs exert toxic effects on many vital organs, including the kidney, blood vessels, and heart.
Suree, Lekawanvijit, Andrew R, Kompa, Henry, Krum   +2 more
openaire   +2 more sources

#254 Assessing middle-molecular and protein-bound uremic toxins: a six-month study of ATA vs PS membranes in hemodiafiltration

Nephrology, Dialysis and Transplantation
Haemodiafiltration (HDF) is highly effective in removing uremic toxins, particularly small molecular weight solutes. However, traditional assessments of dialysis efficiency have focused primarily on small molecules, often overlooking middle ...
Niccolò Morisi, Marco Ferrarini, G. Ligabue, S. Giovanella, Nicola Bonato, Fabrice Innocent Fogue Bwopda, Ettore Tempesti, G. Alfano, Lucia Stipo, Fabio Olmeda, G. Donati   +10 more
semanticscholar   +1 more source

#3259 Intradialytic clearances and reduction ratios for middle molecular weight uremic toxins and protein-bound uremic toxins: comparison of hemodiafiltration with asymmetric cellulose triacetate vs hemodiafiltration with helicoidal polysulfone during a 6-month follow-up

Nephrology, Dialysis and Transplantation
Polysulfone (PS) is to date the most used and versatile material for hemodialysis membranes. The features of permeability and resistance of this material allow its use in hemodiafiltration (HDF) with few alternatives.
Marco Ferrarini, Niccolò Morisi, Giuseppe Di Chiaro, Giuseppe Oliviero, Ylenia Cancelli, G. Ligabue, Fabio Olmeda, Lucia Stipo, S. Giovanella, G. Donati   +9 more
semanticscholar   +1 more source

Vascular Incompetence in Dialysis Patients—Protein‐Bound Uremic Toxins and Endothelial Dysfunction

Seminars in Dialysis, 2011
AbstractPatients with chronic kidney disease (CKD) have a much higher risk of cardiovascular diseases than the general population. Endothelial dysfunction, which participates in accelerated atherosclerosis, is a hallmark of CKD. Patients with CKD display impaired endothelium‐dependent vasodilatation, elevated soluble biomarkers of endothelial ...
Jourde-Chiche, Noemie, Dou, Laetitia, Cerini, Claire, Dignat-George, Francoise, Brunet, Philippe   +4 more
openaire   +3 more sources

#3427 Perdialytic infusion of sodium octanoate improves the dialytic clearance of protein-bound uremic toxins in anephric pigs

Nephrology, Dialysis and Transplantation
Protein-bound uremic toxins (PBUTs) remain a concerning burden in patients with end-stage renal disease since their removal in hemodialysis (HD) is limited by their strong binding to plasma proteins.
Laure-Anne Raillon, Florine Payelle, Lionel Augeul, Nans Florens, Elodie Diaf, Aziz Aberkane, Marie Martin, Jean-Claude Alvarez, Z. Massy, Mikael Croyal, F. Guebre-Egziabher, Christophe O. Soulage   +11 more
semanticscholar   +1 more source

#615 The choice of anti-inflammatory influences the elimination of protein-bound uremic toxins

Nephrology, Dialysis and Transplantation
Pain is a frequent and debilitating symptom affecting nearly 60% of hemodialysis patients, significantly reducing their quality of life. Protein-bound uremic toxins (PBUTs), such as indoxyl sulfate (IS) and p-cresyl sulfate (pCS), contribute to ...
Víctor Joaquín Escudero Saiz, Elena Cuadrado, Maria Iraola, María Rodríguez-García, G. Casals, L. Rodas, Néstor Fontsere Baldellou, María del Carmen Salgado Martín, Carla Bastida, J. B. Monzó, F. Maduell   +10 more
semanticscholar   +1 more source

Increasing the removal of protein‐bound uremic toxins by liposome‐supported hemodialysis

Artificial Organs, 2018
AbstractProtein‐bound uremic toxins (PBUTs) accumulate at high plasma levels and cause various deleterious effects in end‐stage renal disease patients because their removal by conventional hemodialysis is severely limited by their low free‐fraction levels in plasma.
Yuanyuan Shi, Yifeng Wang, Shuai Ma, Tingyan Liu, Huajun Tian, Qiuyu Zhu, Wenji Wang, Yulin Li, Feng Ding   +8 more
openaire   +2 more sources

#2028 Loop diuretics in anuric hemodialysis patients: an unexplored avenue for removal of protein-bound uremic toxins

Nephrology, Dialysis and Transplantation
ESKD is a very difficult kidney problem to have because it can start from many different causes. One of the tough parts about it is how uremic toxins that are bound to protein, like indoxyl sulfate, p-cresyl sulfate, and hippuric acid, keep ...
Didier Sánchez Ospina, Marianne Côté, Maria Isabel Saez Calero, Badawi Hijazi Prieto, Francisco Herrera Gómez, Sandra Delgado Cuesta, Maddalen Mujika Marticorena, Lucia Criado Bellido, E. González-Parra, María Jesús Izquierdo Ortiz, S. Más-Fontao   +10 more
semanticscholar   +1 more source

Ibuprofen-Immobilized Thin Films: A Novel Approach to Improve the Clearance of Protein-Bound Uremic Toxins.

ACS Applied Materials and Interfaces
Chronic kidney disease (CKD), a pressing global health issue, affects millions and leads to end-stage renal disease (ESRD). Hemodialysis (HD) is a crucial treatment for ESRD, yet its limited efficiency in removing protein-bound uremic toxins (PBUTs ...
Flávia S. C. Rodrigues, D. Brilhante, Ana Macêdo, Rita F. Pires, Mónica Faria   +4 more
semanticscholar   +1 more source

Update on the Pharmacokinetics and Redox Properties of Protein-Bound Uremic Toxins

Journal of Pharmaceutical Sciences, 2011
Protein-bound uremic toxins, such as indoxyl sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, p-cresyl sulfate, hippuric acid, and indoleacetic acid, have been the subjects of extensive investigations. In this review, we summarized the recent works providing the new insight on the pharmacokinetics and redox properties of these uremic toxins.
Hiroshi, Watanabe, Yohei, Miyamoto, Masaki, Otagiri, Toru, Maruyama   +3 more
openaire   +2 more sources