Results 171 to 180 of about 15,339 (215)
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Protein-Bound Uremic Toxins and Immunity
2021Protein-bound uremic toxins (PBUTs) are bioactive microbiota metabolites originated exclusively from protein fermentation of the bacterial community resident within the gut microbiota, whose composition and function is profoundly different in the chronic kidney disease (CKD) population. PBUTs accumulate in the later stages of CKD because they cannot be
Rocchetti M. T. +3 more
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Disposition and clinical implications of protein-bound uremic toxins
Clinical Science, 2017In patients with chronic kidney disease (CKD), adequate renal clearance is compromised, resulting in the accumulation of a plethora of uremic solutes. These uremic retention solutes, also named uremic toxins, are a heterogeneous group of organic compounds with intrinsic biological activities, many of which are too large to be filtered and/or are ...
Jansen, J. +4 more
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Cardiorenal Syndrome: Role of Protein-Bound Uremic Toxins
Journal of Renal Nutrition, 2015Renal impairment is a strong independent risk factor associated with poor prognosis in cardiovascular disease patients. Renal dysfunction is likely contributed by progressive renal structural damage. Accurate detection of kidney injury in a timely manner as well as increased knowledge of the pathophysiology and mechanisms underlying this injury is of ...
Suree, Lekawanvijit, Henry, Krum
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PROGRESS IN UREMIC TOXIN RESEARCH: Protein‐Bound Toxins—Update 2009
Seminars in Dialysis, 2009AbstractProtein‐bound uremic retention solutes constitute a group whose common characteristic is their difficult removal by dialysis. In 2003, the EUTox group described 25 protein‐bound solutes. They comprised six advanced glycation end products (AGE), four phenols (including p‐cresol), six indoles (including indoxylsulfate), two hippurates, three ...
Noémie Jourde‐Chiche +5 more
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Protein-bounded uremic toxin p-cresylsulfate induces vascular permeability alternations
Histochemistry and Cell Biology, 2018The goal of the present studies is to investigate that the impact of p-cresylsulfate (PCS) on the endothelial barrier integrity via in situ exposure and systemic exposure. Vascular permeability changes induced by local injection of PCS were evaluated by the techniques of both Evans blue (EB) and India ink tracer.
Wei-Hua Tang +9 more
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ACS Applied Materials and Interfaces
Chronic kidney disease (CKD) is a highly prevalent condition that is associated with an increased burden of cardiovascular diseases and mortality. Between 7% and 12% of the general population are affected by CKD. In patients with end-stage renal disease (
Shujing Wang +5 more
semanticscholar +1 more source
Chronic kidney disease (CKD) is a highly prevalent condition that is associated with an increased burden of cardiovascular diseases and mortality. Between 7% and 12% of the general population are affected by CKD. In patients with end-stage renal disease (
Shujing Wang +5 more
semanticscholar +1 more source
Blood Purification
Introduction: Protein-bound uremic toxins such as advanced glycation end products (AGEs) are poorly cleared by conventional dialysis. Medium cut-off (MCO) membranes have been proposed to enhance their removal, but clinical evidence remains limited ...
Francisca Aranda +5 more
semanticscholar +1 more source
Introduction: Protein-bound uremic toxins such as advanced glycation end products (AGEs) are poorly cleared by conventional dialysis. Medium cut-off (MCO) membranes have been proposed to enhance their removal, but clinical evidence remains limited ...
Francisca Aranda +5 more
semanticscholar +1 more source
Targeting protein-bound uremic toxins in chronic kidney disease
Expert Opinion on Therapeutic Targets, 2013Protein-bound uremic toxins such as indoxyl sulfate cannot be removed efficiently by hemodialysis. These protein-bound uremic toxins have emerged as important risk factors for the progression of chronic kidney disease (CKD) as well as cardiovascular disease (CVD).Indoxyl sulfate shows toxic effects on a variety of cells such as renal proximal tubular ...
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Removal of Protein-Bound Uremic Toxins by Liposome-Supported Peritoneal Dialysis
Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 2019Background Protein-bound uremic toxins (PBUTs) are poorly cleared by peritoneal dialysis (PD). This study aimed to enhance PBUT removal in PD by adding a binder to the peritoneal dialysate and to evaluate the feasibility and efficacy of liposome-supported PD (LSPD) to increase the removal of PBUTs compared with albumin PD.
Yuanyuan, Shi +5 more
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Nephrology, Dialysis and Transplantation
Protein-bound uremic toxins (PBUTs) are low-molecular-weight uremic toxins which encompass different molecules, with indoxyl sulfate (IS) and p-cresyl sulfate (pCS) being two of the most toxic.
Víctor Joaquín Escudero Saiz +9 more
semanticscholar +1 more source
Protein-bound uremic toxins (PBUTs) are low-molecular-weight uremic toxins which encompass different molecules, with indoxyl sulfate (IS) and p-cresyl sulfate (pCS) being two of the most toxic.
Víctor Joaquín Escudero Saiz +9 more
semanticscholar +1 more source