Results 191 to 200 of about 15,339 (215)

[Uremic toxins: the case of protein-bound compounds].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2010
Uremic retention solutes, if biologically or biochemically active, are called ''uremic toxins''. The retention of these solutes has a negative impact on many functions of the organism, particularly the cardiovascular system. The classification which is applied today is based on the kinetic behavior of the uremic retention solutes during dialysis: 1 ...
Carlo, Basile, Pasquale, Libutti, Annalisa, Teutonico, Carlo, Lomonte   +3 more
openaire   +1 more source

New therapeutic perspectives on protein-bound uremic toxins in chronic kidney disease

Expert Opinion on Therapeutic Targets, 2013
The uremic syndrome is a complex mosaic of clinical alterations that may be attributable to one or more of these different solutes. Uremic symptoms in patients with chronic kidney disease are primarily a consequence of inadequate removal and subsequent accumulation of organic products normally metabolized or excreted by the kidney.
openaire   +2 more sources

Kinetics of the protein-bound, lipophilic, uremic toxin p-cresol in healthy rats

Life Sciences, 2001
P-Cresol, a partially lipophilic and protein-bound compound is related to several biochemical alterations in uremia. Because p-cresol kinetics have never been studied, we investigated its kinetic behavior in rats. Results were compared with those obtained with creatinine, a water soluble, non-protein-bound uremic retention solute, which is currently ...
Lesaffer, Gerrit, De Smet, R., Dheuvaert, T, Belpaire, F.m., Lameire, N, Vanholder, Raymond   +5 more
openaire   +3 more sources

Exploring binding characteristics and the related competition of different protein-bound uremic toxins

Biochimie, 2017
Little is known about potential differences in binding characteristics of protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD) versus healthy controls. The question arises whether eventual differences are attributed to (i) the elevated levels of competing uremic toxins, and/or (ii) post-translational modifications of ...
Olivier Deltombe, Henriette de Loor, Griet Glorieux, Annemieke Dhondt, Wim Van Biesen, Björn Meijers, Sunny Eloot   +6 more
openaire   +2 more sources

New Optical Method for Estimation of Protein Bound Uremic Toxins Elimination

2013
The aim of this study was to investigate the possibility to determine the amount of removed Indoxyl Sulphate (IS) during dialysis session. An optical method using fluorescence spectra was used.
J. Holmar, J. Arund, F. Uhlin, R. Tanner, I. Fridolin   +4 more
openaire   +1 more source

Clinical Study on Four-Versus Two-Hour Hemoadsorption Combined with Hemodialysis for Enhanced Claerance of Protein-Bound Uremic Toxins in Maintenance Hemodialysis Patients

Blood Purification
Introduction: The optimal duration of hemoadsorption durations combined with hemodialysis (HAHD) for maintenance hemodialysis (MHD) patients remains unclear.
Yang Lu, Lijuan Zhang, Guosheng Yan, Jun Hu, Xin-Xin Dong, Qi Fang, Guizhen Zhu, Jing-yi Wan, Hong-tao Zhang   +8 more
semanticscholar   +1 more source

Targeting Protein-Bound Uremic Toxins: A Dual Approach with Medium Cut-Off Membrane Dialysis and a Dietary Intervention—A Randomized Controlled Study

Journal of Clinical Medicine
Background/Objectives: Protein-bound uremic toxins (PBUTs), particularly p-cresyl sulfate (PCS) and indoxyl sulfate (IS), are associated with cardiovascular toxicity and increased mortality.
Tjaša Herič, Tjaša Vivoda, Špela Bogataj, Aljoša Kuzmanovski, Jusko Osredkar, Joanna Giebułtowicz, J. Pajek   +6 more
semanticscholar   +1 more source

Animal Models for Studying Protein-Bound Uremic Toxin Removal

Journal of the American Society of Nephrology, 2023
Sabbir Ahmed, Joost C. de Vries, Jingyi Lu, Milan H. Verrijn Stuart, Silvia M. Mihaila, Robin W. Vernooij, Rosalinde Masereeuw, Karin G. Gerritsen   +7 more
openaire   +1 more source

Uremic Toxins and Protein-Bound Therapeutics in AKI and CKD: Up-to-Date Evidence

Toxins, 2022
Jia-Huang Chen, Chih-Kang Chiang
exaly  

Investigation on the Detoxification of Indoxyl Sulfate (IS) and Indole-3-Acetic Acid (IAA) Protein-Bound Uremic Toxins (PBUTs) Using Trametes versicolor Biocompatible Laccase: In Situ Synchrotron Imaging, Experimental and Computational Studies

Applied Biochemistry and Biotechnology
Sana Daneshamouz, Shaghayegh Saadati, Sishi Zhu, D. Kalugin, Ahmed Shoker, A. Abdelrasoul   +5 more
semanticscholar   +1 more source