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Protein-bound uremic toxins: a long overlooked culprit in cardiorenal syndrome
American Journal of Physiology-Renal Physiology, 2016Protein-bound uremic toxins (PBUTs) accumulate once renal excretory function declines and are not cleared by dialysis. There is increasing evidence that PBUTs exert toxic effects on many vital organs, including the kidney, blood vessels, and heart.
Suree, Lekawanvijit +2 more
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Vascular Incompetence in Dialysis Patients—Protein‐Bound Uremic Toxins and Endothelial Dysfunction
Seminars in Dialysis, 2011AbstractPatients with chronic kidney disease (CKD) have a much higher risk of cardiovascular diseases than the general population. Endothelial dysfunction, which participates in accelerated atherosclerosis, is a hallmark of CKD. Patients with CKD display impaired endothelium‐dependent vasodilatation, elevated soluble biomarkers of endothelial ...
Jourde-Chiche, Noemie +4 more
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[Uremic toxins: the case of protein-bound compounds].
Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, 2010Uremic retention solutes, if biologically or biochemically active, are called ''uremic toxins''. The retention of these solutes has a negative impact on many functions of the organism, particularly the cardiovascular system. The classification which is applied today is based on the kinetic behavior of the uremic retention solutes during dialysis: 1 ...
Carlo, Basile +3 more
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Protein-bounded uremic toxin p-cresylsulfate induces vascular permeability alternations
Histochemistry and Cell Biology, 2018The goal of the present studies is to investigate that the impact of p-cresylsulfate (PCS) on the endothelial barrier integrity via in situ exposure and systemic exposure. Vascular permeability changes induced by local injection of PCS were evaluated by the techniques of both Evans blue (EB) and India ink tracer.
Wei-Hua Tang +9 more
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Kinetics of the protein-bound, lipophilic, uremic toxin p-cresol in healthy rats
Life Sciences, 2001P-Cresol, a partially lipophilic and protein-bound compound is related to several biochemical alterations in uremia. Because p-cresol kinetics have never been studied, we investigated its kinetic behavior in rats. Results were compared with those obtained with creatinine, a water soluble, non-protein-bound uremic retention solute, which is currently ...
Lesaffer, Gerrit +5 more
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New therapeutic perspectives on protein-bound uremic toxins in chronic kidney disease
Expert Opinion on Therapeutic Targets, 2013The uremic syndrome is a complex mosaic of clinical alterations that may be attributable to one or more of these different solutes. Uremic symptoms in patients with chronic kidney disease are primarily a consequence of inadequate removal and subsequent accumulation of organic products normally metabolized or excreted by the kidney.
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Biochimie, 2017
Little is known about potential differences in binding characteristics of protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD) versus healthy controls. The question arises whether eventual differences are attributed to (i) the elevated levels of competing uremic toxins, and/or (ii) post-translational modifications of ...
Olivier Deltombe +6 more
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Little is known about potential differences in binding characteristics of protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD) versus healthy controls. The question arises whether eventual differences are attributed to (i) the elevated levels of competing uremic toxins, and/or (ii) post-translational modifications of ...
Olivier Deltombe +6 more
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Clearance of Protein-Bound Uremic Toxins on the Tablo Hemodialysis System
Journal of the American Society of Nephrology, 2021Logan Rivas, Dean Hu, Michael A. Aragon
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Animal Models for Studying Protein-Bound Uremic Toxin Removal
Journal of the American Society of Nephrology, 2023Sabbir Ahmed +7 more
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Protein-Bound Uremic Toxins Binding to Human Serum Albumin
Kidney failure is a global health concern, exacerbated by the accumulation of uremic metabolites that persist despite conventional treatments such as hemodialysis (HD). A significant subset of these metabolites, termed protein-bound uremic toxins (PBUTs), bind tightly to human serum albumin (HSA), limiting their removal through traditional separation ...openaire +1 more source