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Removal of Protein-Bound Uremic Toxins during Hemodialysis Using a Binding Competitor. [PDF]
Clin J Am Soc Nephrol, 2019 Madero M +9 more
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Protein-Bound Uremic Toxins and Immunity
2021Protein-bound uremic toxins (PBUTs) are bioactive microbiota metabolites originated exclusively from protein fermentation of the bacterial community resident within the gut microbiota, whose composition and function is profoundly different in the chronic kidney disease (CKD) population. PBUTs accumulate in the later stages of CKD because they cannot be
Rocchetti M. T. +3 more
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Improved Dialysis Removal of Protein-Bound Uremic Toxins by Salvianolic Acids
Phytomedicine, 2019Indoxyl sulfate (IS) and p-cresyl sulfate (pCS) are two key protein-bound uremic toxins that accumulate in patients with end-stage renal disease. IS and pCS cannot be efficiently removed by conventional hemodialysis because they are highly bound to proteins.
Jin-Ao Duan, Jianming Guo, Jianping Li
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Cardiorenal Syndrome: Role of Protein-Bound Uremic Toxins
Journal of Renal Nutrition, 2015Renal impairment is a strong independent risk factor associated with poor prognosis in cardiovascular disease patients. Renal dysfunction is likely contributed by progressive renal structural damage. Accurate detection of kidney injury in a timely manner as well as increased knowledge of the pathophysiology and mechanisms underlying this injury is of ...
Suree, Lekawanvijit, Henry, Krum
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Update on the Pharmacokinetics and Redox Properties of Protein-Bound Uremic Toxins
Journal of Pharmaceutical Sciences, 2011Protein-bound uremic toxins, such as indoxyl sulfate, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, p-cresyl sulfate, hippuric acid, and indoleacetic acid, have been the subjects of extensive investigations. In this review, we summarized the recent works providing the new insight on the pharmacokinetics and redox properties of these uremic toxins.
Hiroshi, Watanabe +3 more
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PROGRESS IN UREMIC TOXIN RESEARCH: Protein‐Bound Toxins—Update 2009
Seminars in Dialysis, 2009AbstractProtein‐bound uremic retention solutes constitute a group whose common characteristic is their difficult removal by dialysis. In 2003, the EUTox group described 25 protein‐bound solutes. They comprised six advanced glycation end products (AGE), four phenols (including p‐cresol), six indoles (including indoxylsulfate), two hippurates, three ...
Noémie Jourde‐Chiche +5 more
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Protein-Bound Uremic Toxins: A Long Overlooked Culprit in Cardiorenal Syndrome
American Journal of Physiology - Renal Physiology, 2016Protein-bound uremic toxins (PBUTs) accumulate once renal excretory function declines and are not cleared by dialysis. There is increasing evidence that PBUTs exert toxic effects on many vital organs, including the kidney, blood vessels, and heart.
Henry Krum +2 more
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Increasing the removal of protein‐bound uremic toxins by liposome‐supported hemodialysis
Artificial Organs, 2018AbstractProtein‐bound uremic toxins (PBUTs) accumulate at high plasma levels and cause various deleterious effects in end‐stage renal disease patients because their removal by conventional hemodialysis is severely limited by their low free‐fraction levels in plasma.
Yuanyuan Shi +8 more
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Targeting protein-bound uremic toxins in chronic kidney disease
Expert Opinion on Therapeutic Targets, 2013Protein-bound uremic toxins such as indoxyl sulfate cannot be removed efficiently by hemodialysis. These protein-bound uremic toxins have emerged as important risk factors for the progression of chronic kidney disease (CKD) as well as cardiovascular disease (CVD).Indoxyl sulfate shows toxic effects on a variety of cells such as renal proximal tubular ...
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