Results 11 to 20 of about 8,952,616 (310)
Controllability Analysis of Intercellular Protein–Protein Interaction Networks [PDF]
Computational and Structural Biotechnology JournalUnderstanding how control is organized across interacting cells is an important challenge in computational and systems biology, especially in diseases involving disrupted communication among different cell types. Although network controllability analysis
Hikari Nozaki +3 more
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Molecules, 2023 The growing applications of peptide-based therapeutics require the development of efficient protocols from the perspective of an industrial scale-up. T3P® (cyclic propylphosphonic anhydride) promotes amidation in the solution-phase through a biomimetic ...
Alexia Mattellone +7 more
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Identification of photocrosslinking peptide ligands by mRNA display
Communications Chemistry, 2023 Photoaffinity labelling is a promising method for studying protein-ligand interactions. However, obtaining a specific, efficient crosslinker can require significant optimisation.
Yuteng Wu +5 more
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Contextualized Protein-Protein Interactions [PDF]
Patterns, 2021 Protein-protein interaction (PPI) databases are an important bioinformatics resource, yet existing literature-curated databases usually represent cell-type-agnostic interactions, which is at variance with our understanding that protein dynamics are context specific and highly dependent on their environment.
Anthony Federico, Stefano Monti
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Developing methods to study conformational changes in RNA crystals using a photocaged ligand
Frontiers in Molecular Biosciences, 2022 Crystallographic observation of structural changes in real time requires that those changes be uniform both spatially and temporally. A primary challenge with time-resolved ligand-mixing diffraction experiments is asynchrony caused by variable factors ...
Hyun Kyung Lee +8 more
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Diversity of protein–protein interactions [PDF]
The EMBO Journal, 2003 In this review, we discuss the structural and functional diversity of protein-protein interactions (PPIs) based primarily on protein families for which three-dimensional structural data are available. PPIs play diverse roles in biology and differ based on the composition, affinity and whether the association is permanent or transient.
Irene M A, Nooren, Janet M, Thornton
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Frontiers in Immunology, 2021 Kawasaki disease (KD) is a febrile disease of childhood characterized by systemic vasculitis that can lead to coronary artery lesions (CAL). This was a prospective cohort study to determine the levels of the pentraxin 3 (PTX3), soluble CD24-Subtype ...
Toshiyuki Kitoh +11 more
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Visualizing RNA conformational and architectural heterogeneity in solution
Nature Communications, 2023 RNA conformational heterogeneity is important to diverse functions. Here, the authors use AFM to directly visualize individual RNA molecules that are in various conformational states under near physiological solution conditions for the first time.
Jienyu Ding +12 more
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The Landscape of Virus-Host Protein–Protein Interaction Databases
Frontiers in Microbiology, 2022 Knowledge of virus-host interactomes has advanced exponentially in the last decade by the use of high-throughput screening technologies to obtain a more comprehensive landscape of virus-host protein–protein interactions.
Gabriel Valiente
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Allo-network drugs: Extension of the allosteric drug concept to protein-protein interaction and signaling networks [PDF]
, 2013 Allosteric drugs are usually more specific and have fewer side effects than orthosteric drugs targeting the same protein. Here, we overview the current knowledge on allosteric signal transmission from the network point of view, and show that most ...
Csermely, Péter +3 more
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