Hsp90 Breaks the Deadlock of the Hsp70 Chaperone System [PDF]
Protein folding in the cell requires ATP-driven chaperone machines such as the conserved Hsp70 and Hsp90. It is enigmatic how these machines fold proteins.
Mayer, Matthias +5 more
core +2 more sources
Construction and analysis of the protein-protein interaction network of visual system in Drosophila [PDF]
Insects are one of the most widely distributed animals on earth, and their visual systems have strong adaptability, deeply affecting their survival, reproduction, diet, and environmental adaptation.
JiaNing Sun, WenJun Zhang
doaj
Sequence Motifs in MADS Transcription Factors Responsible for Specificity and Diversification of Protein-Protein Interaction [PDF]
Protein sequences encompass tertiary structures and contain information about specific molecular interactions, which in turn determine biological functions of proteins.
Angenent, G.C. +23 more
core +2 more sources
Expressed protein ligation for a large dimeric protein [PDF]
Expressed protein ligation (EPL) is a protein engineering tool for post-translational ligation of protein or peptide fragments. This technique allows modification of specific parts of proteins, opening possibilities for incorporating probes for ...
NMR Spectroscopy +11 more
core +1 more source
Pyramidalization of the Glycosidic Nitrogen Provides the Way for Efficient Cleavage of the N‑Glycosidic Bond of 8‑OxoG with the hOGG1 DNA Repair Protein [PDF]
A mechanistic pathway for cleavage of the N-glycosidic bond of 8-oxo-2′-deoxyguanosine (oxoG) catalyzed with the human 8-oxoguanine glycosylase 1 DNA repair protein (hOGG1) is proposed in this theoretical study. The reaction scheme suggests direct proton
Sychrovský, V. +5 more
core +1 more source
Predicting protein phenotypes based on protein-protein interaction network. [PDF]
BackgroundIdentifying associated phenotypes of proteins is a challenge of the modern genetics since the multifactorial trait often results from contributions of many proteins.
Lele Hu +3 more
doaj +1 more source
Picky Hsp90-Every Game with Another Mate [PDF]
In this issue of Molecular Cell, Sahasrabudhe et al. (2017) present a dramatically renovated functional cycle for the molecular chaperone Hsp90, which stimulates re-thinking of the mechanism of this vital protein folding ...
Sub Cellular Protein Chemistry +3 more
core +2 more sources
Mitogen‐activated protein kinases (MAPK) are broadly used regulators of cellular signaling. However, how these enzymes can be involved in such a broad spectrum of physiological functions is not understood.
András Zeke +8 more
doaj +1 more source
Evolutionarily conserved herpesviral protein interaction networks. [PDF]
Herpesviruses constitute a family of large DNA viruses widely spread in vertebrates and causing a variety of different diseases. They possess dsDNA genomes ranging from 120 to 240 kbp encoding between 70 to 170 open reading frames. We previously reported
Bandyopadhyay, Sourav +79 more
core +1 more source
Relation Extraction of Protein Complexes from Dynamic Protein-Protein Interaction Network [PDF]
Background: Dynamic protein-protein interaction networks (DPPIN) can confirm the conditional and temporal features of proteins and protein complexes. In addition, the relation of protein complexes in dynamic networks can provide useful information in ...
Moslem Mohammadi Jenghara +2 more
doaj +1 more source

