Results 31 to 40 of about 3,268,890 (286)

SnapShot: Protein-Protein Interaction Networks

Cell, 2011
Methods MethodsYeast two-hybridProtein fragment complementationassayTranscription factor, ubiquitinDehydrofolate reductaseGFP or YFPProtein pairs+ Interacting- NoninteractingInteraction examples- Signaling- Enzyme - substrateInteraction strength-Transient to stableAffinity purification/Mass spectrometryBiochemical purification of affinity-tagged baits ...
Seebacher, Jan, Gavin Perrin, Anne-Claude   +1 more
openaire   +3 more sources

Global protein function prediction in protein-protein interaction networks

, 2003
The determination of protein functions is one of the most challenging problems of the post-genomic era. The sequencing of entire genomes and the possibility to access gene's co-expression patterns has moved the attention from the study of single proteins
Flammini, A., Maritan, A., Vazquez, A., Vespignani, A.   +3 more
core   +2 more sources

Heterologous prion-forming proteins interact to cross-seed aggregation in Saccharomyces cerevisiae [PDF]

, 2017
The early stages of protein misfolding remain incompletely understood, as most mammalian proteinopathies are only detected after irreversible protein aggregates have formed.
Keefer, Kathryn M, Stein, Kevin C, true, Heather L   +2 more
core   +2 more sources

Sensitivity dependent model of protein-protein interaction networks

, 2008
The scale free structure p(k)~k^{-gamma} of protein-protein interaction networks can be reproduced by a static physical model in simulation. We inspect the model theoretically, and find the key reason for the model to generate apparent scale free degree ...
Estojak J, Eugene I Shakhnovich, Jingshan Zhang, Wagner A   +3 more
core   +1 more source

Local pre-processing for node classification in networks : application in protein-protein interaction [PDF]

, 2013
Network modelling provides an increasingly popular conceptualisation in a wide range of domains, including the analysis of protein structure. Typical approaches to analysis model parameter values at nodes within the network. The spherical locality around
Al Azwari, Sana Mohammad M, Dufton, Mark, Foley, Christopher Eric, Ross, Isla, Wilson, John   +4 more
core   +1 more source

Clustering Coefficients of Protein-Protein Interaction Networks

, 2007
The properties of certain networks are determined by hidden variables that are not explicitly measured. The conditional probability (propagator) that a vertex with a given value of the hidden variable is connected to k of other vertices determines all ...
B. Alberts, Gerald A. Miller, Hong Qian, Karol Bomsztyk, Yi Y. Shi   +4 more
core   +1 more source

Stereochemical assignment of the protein-protein interaction inhibitor JBIR-22 by total synthesis [PDF]

, 2015
The authors acknowledge the EPSRC and Cancer Research UK (CRUK Grant No. C21383/A6950) for funding this research.Recent reports have highlighted the biological activity associated with a sub-family of the tetramic acid class of natural products.
Healy, Alan, Izumikawa, Miho, Shin-ya, Kazuo, Slawin, Alexandra Martha Zoya, Westwood, Nicholas James   +4 more
core   +1 more source

Discovering functional interaction patterns in protein-protein interaction networks

BMC Bioinformatics, 2008
Background In recent years, a considerable amount of research effort has been directed to the analysis of biological networks with the availability of genome-scale networks of genes and/or proteins of an increasing number of organisms.
Can Tolga, Turanalp Mehmet E
doaj   +1 more source

Disposition of Federally Owned Surpluses [PDF]

, 1944
PDZ domains are scaffolding modules in protein-protein interactions that mediate numerous physiological functions by interacting canonically with the C-terminus or non-canonically with an internal motif of protein ligands. A conserved carboxylate-binding
A Bach, A Bach, A Bach, BA Appleton, BH Chang, BJ Hillier, BZ Harris, CN Chi, CN Chi, CN Chi, DA Doyle, E Chapman, E Kim, E Kim, ET Powers, FI Valiyaveetil, G Hultqvist, GM Elias, GS Beligere, H Remaut, H Tochio, H Tochio, HJ Lee, J Schultz, J Schultz, JA Wells, JF Amacher, JNN Eildal, JT Andreasen, JT Koh, KK Dev, KS Bateman, L Funke, M Aarts, M Sheng, M Vila-Perelló, MA Stiffler, MD Hill, MR Arkin, N Calosci, NX Wang, OA Karlsson, R Tonikian, RN McLaughlin Jr., S Deechongkit, S Seedorff, SH Gee, TW Muir, W Feng, Y Zhang, Z Songyang   +50 more
core   +2 more sources

Structural insight into the function of human peptidyl arginine deiminase 6

Computational and Structural Biotechnology Journal
Peptidyl arginine deiminase 6 (PADI6 or PAD6) is vital for early embryonic development in mice and humans, yet its function remains elusive. PADI6 is less conserved than other PADIs and it is currently unknown whether it has a catalytic function. Here we
Jack P.C. Williams, Stephane Mouilleron, Rolando Hernandez Trapero, M. Teresa Bertran, Joseph A. Marsh, Louise J. Walport   +5 more
doaj   +1 more source