Results 41 to 50 of about 2,229,273 (315)

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Discovering covalent cyclic peptide inhibitors of peptidyl arginine deiminase 4 (PADI4) using mRNA-display with a genetically encoded electrophilic warhead

Communications Chemistry
Covalent drugs can achieve high potency with long dosing intervals. However, concerns remain about side-effects associated with off-target reactivity.
Isabel R. Mathiesen, Ewen D. D. Calder, Simone Kunzelmann, Louise J. Walport   +3 more
doaj   +1 more source

Structural insight into the function of human peptidyl arginine deiminase 6

Computational and Structural Biotechnology Journal
Peptidyl arginine deiminase 6 (PADI6 or PAD6) is vital for early embryonic development in mice and humans, yet its function remains elusive. PADI6 is less conserved than other PADIs and it is currently unknown whether it has a catalytic function. Here we
Jack P.C. Williams, Stephane Mouilleron, Rolando Hernandez Trapero, M. Teresa Bertran, Joseph A. Marsh, Louise J. Walport   +5 more
doaj   +1 more source

Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTpp.

, 2012
The biophysical stability is an important parameter for protein activity both in vivo and in vitro. Here we propose a method to analyse thermal melting of protein domains in lysates: Fast parallel proteolysis (FASTpp).
Rüdiger, Stefan G. D., Stefan G D Rüdiger, Maurice, Madelon M., David P Minde, Sub Cellular Protein Chemistry, Stefan G. D. Rüdiger, Madelon M Maurice, Minde, David P., Cellular Protein Chemistry, David P. Minde, Madelon M. Maurice   +10 more
core   +1 more source

Effects of the Fluid Replacement Method During Online Hemodiafiltration on the Solute Removal Performance and Biocompatibility Using the Asymmetric Cellulose Triacetate Membrane

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Pre‐dilution online hemodiafiltration (Pre‐HDF) is predominantly used in Japan, whereas post‐dilution online HDF (Post‐HDF) is more common in Europe. An asymmetric cellulose triacetate (ATA) membrane may improve biocompatibility.
Kenji Sakurai, Yoshitaka Kurihara, Fumi Yamauchi, Hiromi Hosoya, Takeshi Saito   +4 more
wiley   +1 more source

HPLC for at-line reaction monitoring and purification improves yield and purity of tRNA

Frontiers in Molecular Biosciences
Engineered transfer RNA is an emerging therapeutic modality, particularly suited to treatment of diseases caused by genetic disorders based on premature termination codons, frameshifts, or missense mutations.
Polona Megušar, Ewen D. D. Calder, Ewen D. D. Calder, Tina Vodopivec Seravalli, Sergeja Lebar, Louise J. Walport, Louise J. Walport, Rok Sekirnik   +7 more
doaj   +1 more source

Protein-Protein Interaction Analysis by Docking

Algorithms, 2009
Based on a protein-protein docking approach we have developed a procedure to verify or falsify protein-protein interactions that were proposed by other methods such as yeast-2-hybrid assays.
Stephan Ederer, Florian Fink, Wolfram Gronwald   +2 more
doaj   +1 more source

Protein- protein interaction network for common DEGs.

, 2023
All disconnected nodes were removed from the network. The sphere represents node (protein encoded by the gene) and the line depicts interaction. The color of the line is representative of the source of evidence for interaction, including text mining ...
Attya Bhatti (4762944), Peter John (36428), Ilhaam Ayaz Durrani (16806762)   +2 more
core   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Structural basis for protein-free catalysis by ribonuclease P ribozyme

Nature Communications
Ribonuclease P (RNase P) is an essential metallonuclease found in all three domains of life. However, the structural basis for the ancient RNase P RNA component acting alone as a ribozyme and catalytic metal-ion chemistry remains unknown.
Yun-Tzai Lee, Maximilia F. S. Degenhardt, Ilias Skeparnias, Szu-Yun Chen, Bapurao A. Bhoge, Sergey G. Tarasov, Marzena A. Dyba, Jinwei Zhang, Jason R. Stagno, Yun-Xing Wang   +9 more
doaj   +1 more source