Results 61 to 70 of about 8,952,616 (310)

Protein-Protein Interaction Analysis by Docking

Algorithms, 2009
Based on a protein-protein docking approach we have developed a procedure to verify or falsify protein-protein interactions that were proposed by other methods such as yeast-2-hybrid assays.
Stephan Ederer, Florian Fink, Wolfram Gronwald   +2 more
doaj   +1 more source

Principles of protein-protein interactions [PDF]

Bioinformatics, 2002
Abstract In the postgenomic era, one of the most interesting and important challenges is to understand protein interactions on a large scale. The physical interactions between protein domains are fundamental to the workings of a cell: in multi-domain polypeptide chains, in multi-subunit proteins and in transient complexes between ...
openaire   +3 more sources

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

SLIDER: Mining correlated motifs in protein-protein interaction networks [PDF]

, 2009
—Correlated motif mining (CMM) is the problem to find overrepresented pairs of patterns, called motif pairs, in interacting protein sequences. Algorithmic solutions for CMM thereby provide a computational method for predicting binding sites for protein ...
Boyen, P., Dijk, A.D.J., van, Ham, R.C.H.J., van, Neven, F.   +3 more
core  

Structural basis for protein-free catalysis by ribonuclease P ribozyme

Nature Communications
Ribonuclease P (RNase P) is an essential metallonuclease found in all three domains of life. However, the structural basis for the ancient RNase P RNA component acting alone as a ribozyme and catalytic metal-ion chemistry remains unknown.
Yun-Tzai Lee, Maximilia F. S. Degenhardt, Ilias Skeparnias, Szu-Yun Chen, Bapurao A. Bhoge, Sergey G. Tarasov, Marzena A. Dyba, Jinwei Zhang, Jason R. Stagno, Yun-Xing Wang   +9 more
doaj   +1 more source

The Arginine-Rich Motif of Bamboo mosaic virus Satellite RNA-Encoded P20 Mediates Self-Interaction, Intracellular Targeting, and Cell-to-Cell Movement

Molecular Plant-Microbe Interactions, 2006
Satellite RNA of Bamboo mosaic virus (satBaMV) has a single open reading frame for a nonstructural, RNA-binding protein, P20, which facilitates the long-distance movement of satBaMV in Nicotiana benthamiana.
Paramasivan Vijaya Palani, Venkatraman Kasiviswanathan, Jeff Chien-Fu Chen, Wei Chen, Yau-Heiu Hsu, Na-Sheng Lin   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Challenges and opportunities in technologies and methods for lncRNA structure determination

Cell & Bioscience
Long non-coding RNAs (lncRNAs) play pivotal roles in diverse cellular processes ranging from gene regulation and chromatin remodeling to RNA stability and epigenetic modifications. Despite the identification of approximately 95,000 lncRNA genes in humans,
Maximilia Frazao De Souza Degenhardt, Yun-Xing Wang   +1 more
doaj   +1 more source

Discover protein sequence signatures from protein-protein interaction data

BMC Bioinformatics, 2005
Background The development of high-throughput technologies such as yeast two-hybrid systems and mass spectrometry technologies has made it possible to generate large protein-protein interaction (PPI) datasets.
Haasl Ryan J, Fang Jianwen, Dong Yinghua, Lushington Gerald H   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source