Results 81 to 90 of about 2,229,273 (315)

Phospho‐tyrosine dependent protein–protein interaction network

Molecular Systems Biology, 2015
Post‐translational protein modifications, such as tyrosine phosphorylation, regulate protein–protein interactions (PPIs) critical for signal processing and cellular phenotypes.
Arndt Grossmann, Nouhad Benlasfer, Petra Birth, Anna Hegele, Franziska Wachsmuth, Luise Apelt, Ulrich Stelzl   +6 more
doaj   +1 more source

Protein-protein interaction based on pairwise similarity

BMC Bioinformatics, 2009
Background Protein-protein interaction (PPI) is essential to most biological processes. Abnormal interactions may have implications in a number of neurological syndromes.
Zaki Nazar, Lazarova-Molnar Sanja, El-Hajj Wassim, Campbell Piers   +3 more
doaj   +1 more source

Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome [PDF]

, 2007
The severe acute respiratory syndrome coronavirus (SARS-CoV) genome is predicted to encode 14 functional open reading frames, leading to the expression of up to 30 structural and non-structural protein products.
Brunn, Albrecht von, Teepe, Carola, Caroline C Friedel, Ralph Baric, Haas, Jürgen, von Brunn, Albrecht, Simpson Jeremy C., Jeremy C. Simpson, Simpson, Jeremy C., Ralf Zimmer, Roberts, Rhonda, Carola Teepe, Rainer Pepperkok, Baric Ralph, Haas Jürgen, Simpson, Jeremy, Zimmer, Ralf, Zimmer Ralf, Caroline C. Friedel, Friedel, Caroline C., Haas, Juergen, Teepe Carola, Albrecht von Brunn, Rhonda Roberts, Jürgen Haas, Friedel Caroline C., Pepperkok Rainer, Pepperkok, Rainer, Roberts Rhonda, Baric, Ralph, Jeremy C Simpson, von Brunn Albrecht   +31 more
core   +1 more source

Protein-protein interaction network of interconnected BRD-associated hub genes.

, 2022
Protein-protein interaction network of interconnected BRD-associated hub genes.
Brandi B. Karisch (8292909), Amelia R. Woolums (8292903), Cyprianna E. Swiderski (8292906), Bindu Nanduri (21937), Andy D. Perkins (5010149), Matthew A. Scott (3915533), Abigail Finley (14053224)   +6 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A system for the evolution of protein-protein interaction inducers

, 2021
Molecules that induce interactions between proteins, often referred to as “molecular glues”, are increasingly recognized as important therapeutic modalities and as entry points for rewiring cellular signaling networks.
Jeffrey, Dewey, Bryan, Dickinson, Saara-Anne, Azizi, Vivian, Lu   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Semi-supervised prediction of protein interaction sentences exploiting semantically encoded metrics [PDF]

, 2009
Protein-protein interaction (PPI) identification is an integral component of many biomedical research and database curation tools. Automation of this task through classification is one of the key goals of text mining (TM).
Polajnar, T., Tamara Polajnar, Mark Girolami, Girolami, M.   +3 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source