Results 91 to 100 of about 2,229,273 (315)

Modularity detection in protein-protein interaction networks

BMC Research Notes, 2011
Background Many recent studies have investigated modularity in biological networks, and its role in functional and structural characterization of constituent biomolecules.
Narayanan Tejaswini, Gersten Merril, Subramaniam Shankar, Grama Ananth   +3 more
doaj   +1 more source

Protein-RNA interactions: a structural analysis

, 2001
A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT, Berman, HM, Luscombe, NM, Helen M Berman (10123868), Susan Jones (4079), Thornton, JM, David T A Daley (16115222), Janet M Thornton (16060073), Jones, S, Nicholas M Luscombe (8114756)   +9 more
core  

Protein-Protein interaction in Obstructive Sleep Apnea.docx

, 2019
study analyzing the protein-protein interaction in patients with obstructive sleep apnea through high-throughput cell biology ...
Rosalind Silverman (5253824), Lorelei Silverman (5205368), Mariam Eldaba (7862213)   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

NOXclass: prediction of protein-protein interaction types

BMC Bioinformatics, 2006
Background Structural models determined by X-ray crystallography play a central role in understanding protein-protein interactions at the molecular level.
Sommer Ingolf, Domingues Francisco S, Zhu Hongbo, Lengauer Thomas   +3 more
doaj   +1 more source

SLIDER: Mining correlated motifs in protein-protein interaction networks

, 2009
—Correlated motif mining (CMM) is the problem to find overrepresented pairs of patterns, called motif pairs, in interacting protein sequences. Algorithmic solutions for CMM thereby provide a computational method for predicting binding sites for protein ...
Boyen, P., Dijk, A.D.J., van, Ham, R.C.H.J., van, Neven, F.   +3 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Unified Alignment of Protein-Protein Interaction Networks

Scientific Reports, 2017
Paralleling the increasing availability of protein-protein interaction (PPI) network data, several network alignment methods have been proposed. Network alignments have been used to uncover functionally conserved network parts and to transfer annotations.
Noël Malod-Dognin, Kristina Ban, Nataša Pržulj   +2 more
doaj   +1 more source

Local pre-processing for node classification in networks : application in protein-protein interaction

, 2013
Network modelling provides an increasingly popular conceptualisation in a wide range of domains, including the analysis of protein structure. Typical approaches to analysis model parameter values at nodes within the network. The spherical locality around
Ross, Isla, John N. Wilson, Foley, Christopher Eric, Isla Ross, Wilson, John, Mark Dufton, Dufton, Mark, Sana Al Azwari, Al Azwari, Sana Mohammad M, Christopher E. Foley   +9 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source