Results 91 to 100 of about 8,952,616 (310)
A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV regulation
Nature CommunicationsPeptidylarginine deiminase IV (PADI4, PAD4) deregulation promotes the development of autoimmunity, cancer, atherosclerosis and age-related tissue fibrosis.
M. Teresa Bertran +18 more
doaj +1 more source
Modularity detection in protein-protein interaction networks
BMC Research Notes, 2011 Background Many recent studies have investigated modularity in biological networks, and its role in functional and structural characterization of constituent biomolecules.
Narayanan Tejaswini +3 more
doaj +1 more source
SnapShot: Protein-Protein Interaction Networks
Cell, 2011 Methods MethodsYeast two-hybridProtein fragment complementationassayTranscription factor, ubiquitinDehydrofolate reductaseGFP or YFPProtein pairs+ Interacting- NoninteractingInteraction examples- Signaling- Enzyme - substrateInteraction strength-Transient to stableAffinity purification/Mass spectrometryBiochemical purification of affinity-tagged baits ...
Seebacher, Jan +1 more
openaire +2 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
, 2023 Protein-protein-interaction network analysis of TFs predicted by at least 4, 5, or 6 tools using STRING Database for gene list analysis.
Louis Li (17508116) +4 more
core +1 more source
NOXclass: prediction of protein-protein interaction types
BMC Bioinformatics, 2006 Background Structural models determined by X-ray crystallography play a central role in understanding protein-protein interactions at the molecular level.
Sommer Ingolf +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Protein-protein interaction network of identified C. parvum proteins generated using Cytoscape.
, 2021 The degree represents the strength of the protein interaction. (TIF)
Teng Li (279243) +7 more
core +1 more source
RocSampler: regularizing overlapping protein complexes in protein-protein interaction networks
BMC Bioinformatics, 2017 Background In recent years, protein-protein interaction (PPI) networks have been well recognized as important resources to elucidate various biological processes and cellular mechanisms.
Osamu Maruyama, Yuki Kuwahara
doaj +1 more source