Systematic discovery of new recognition peptides mediating protein interaction networks. [PDF]
PLoS Biology, 2005 Many aspects of cell signalling, trafficking, and targeting are governed by interactions between globular protein domains and short peptide segments. These domains often bind multiple peptides that share a common sequence pattern, or "linear motif" (e.g.,
Victor Neduva +9 more
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Diversity of short linear interaction motifs in SARS-CoV-2 nucleocapsid protein
mBio, 2023 Molecular mimicry of short linear interaction motifs has emerged as a key mechanism for viral proteins binding host domains and hijacking host cell processes.
Peter Schuck, Huaying Zhao
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ADAN: a database for prediction of protein–protein interaction of modular domains mediated by linear motifs [PDF]
Bioinformatics, 2009 Abstract Motivation: Most of the structures and functions of proteome globular domains are yet unknown. We can use high-resolution structures from different modular domains in combination with automatic protein design algorithms to predict genome-wide potential interactions of a protein.
Pedro Beltrão +2 more
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A complex interplay of various intracellular motifs determines G protein binding and activation of muscarinic receptors [PDF]
Scientific ReportsG protein coupled receptors (GPCRs) mediate intracellular signaling by selectively activating heterotrimeric G proteins. While certain GPCRs exhibit a high specificity toward particular G protein subtypes, other GPCRs display promiscuous signaling by ...
Sina B. Kirchhofer +4 more
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Actinin-associated LIM Protein: Identification of a Domain Interaction between PDZ and Spectrin-like Repeat Motifs [PDF]
Journal of Cell Biology, 1997 PDZ motifs are protein–protein interaction domains that often bind to COOH-terminal peptide sequences. The two PDZ proteins characterized in skeletal muscle, syntrophin and neuronal nitric oxide synthase, occur in the dystrophin complex, suggesting a role for PDZ proteins in muscular dystrophy.
David Bredt, M R Altherr, Bredt David S
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The POZ domain: a conserved protein-protein interaction motif. [PDF]
Genes & Development, 1994 We describe a novel zinc finger protein, ZID (zinc finger protein with interaction domain). At its amino terminus ZID contains a 120-amino-acid conserved motif present in a large family of proteins that includes both the otherwise unrelated zinc finger proteins, such as Ttk, GAGA, and ZF5, and a group of poxvirus proteins: We therefore refer to this ...
V J, Bardwell, R, Treisman
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PeerJ, 2018 [This corrects the article DOI: 10.7717/peerj.5858.].
Idrees, Sobia +2 more
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Identification of a novel zinc-binding protein, C1orf123, as an interactor with a heavy metal-associated domain. [PDF]
PLoS ONE, 2018 Heavy metal-associated (HMA) domains bind metal ions at its Cys-x-x-Cys (CxxC) motif and constitute an intracellular network for trafficking of metal ions for utilization and detoxification.
Yoshiaki Furukawa +8 more
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Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins [PDF]
BMC Immunology, 2016 Major histocompatibility complex class I (MHCI) proteins present antigenic peptides for immune surveillance and play critical roles in nervous system development and plasticity. Most MHCI are transmembrane proteins. The extracellular domain of MHCI interacts with immunoreceptors, peptides, and co-receptors to mediate immune signaling.
Frietze, Karla K. +6 more
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A dynamic view of domain-motif interactions. [PDF]
PLoS Computational Biology, 2012 Many protein-protein interactions are mediated by domain-motif interaction, where a domain in one protein binds a short linear motif in its interacting partner.
Eyal Akiva +3 more
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