Results 11 to 20 of about 165,231 (306)

Predicting peptide-mediated interactions on a genome-wide scale. [PDF]

PLoS Computational Biology, 2015
We describe a method to predict protein-protein interactions (PPIs) formed between structured domains and short peptide motifs. We take an integrative approach based on consensus patterns of known motifs in databases, structures of domain-motif complexes
T Scott Chen, Donald Petrey, Jose Ignacio Garzon, Barry Honig   +3 more
doaj   +1 more source

ImitateDB: A database for domain and motif mimicry incorporating host and pathogen protein interactions

Amino Acids, 2022
Molecular mimicry of host proteins by pathogens constitutes a strategy to hijack the host pathways. At present, there is no dedicated resource for mimicked domains and motifs in the host-pathogen interactome. In this work, the experimental host-pathogen (HP) and host-host (HH) protein-protein interactions (PPIs) were collated. The domains and motifs of
Sonali Tayal, Venugopal Bhatia, Tanya Mehrotra, Sonika Bhatnagar   +3 more
openaire   +2 more sources

Novel linear motif filtering protocol reveals the role of the LC8 dynein light chain in the Hippo pathway. [PDF]

PLoS Computational Biology, 2017
Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases.
Gábor Erdős, Tamás Szaniszló, Mátyás Pajkos, Borbála Hajdu-Soltész, Bence Kiss, Gábor Pál, László Nyitray, Zsuzsanna Dosztányi   +7 more
doaj   +1 more source

Mutational Analysis of the GXXXG/A Motifs in the Human Na+/Taurocholate Co-Transporting Polypeptide NTCP on Its Bile Acid Transport Function and Hepatitis B/D Virus Receptor Function

Frontiers in Molecular Biosciences, 2021
Homodimerization is essential for plasma membrane sorting of the liver bile acid transporter NTCP and its function as Hepatitis B/D Virus (HBV/HDV) receptor. However, the protein domains involved in NTCP dimerization are unknown. NTCP bears two potential
Massimo Palatini, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Saskia Noppes, Jörg Alber, Felix Lehmann, Nora Goldmann, Dieter Glebe, Joachim Geyer   +8 more
doaj   +1 more source

A Novel Protein Interaction between Nucleotide Binding Domain of Hsp70 and p53 Motif [PDF]

International Journal of Genomics, 2015
Currently, protein interaction ofHomo sapiensnucleotide binding domain (NBD) of heat shock 70 kDa protein (PDB: 1HJO) with p53 motif remains to be elucidated. The NBD-p53 motif complex enhances the p53 stabilization, thereby increasing the tumor suppression activity in cancer treatment. Therefore, we identified the interaction between NBD and p53 using
Elengoe, Asita, Naser, Mohammed Abu, Hamdan, Salehhuddin   +2 more
openaire   +4 more sources

Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome [PDF]

, 2013
A key signature of module exchange in the genome is phase symmetry of exons, suggestive of exon shuffling events that occurred without disrupting translation reading frame.
Kalmár, Lajos, Schád, Éva, Tompa, Péter   +2 more
core   +1 more source

Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. [PDF]

PLoS ONE, 2012
The protein Sam68 is involved in many cellular processes such as cell-cycle regulation, RNA metabolism, or signal transduction. Sam68 comprises a central RNA-binding domain flanked by unstructured tails containing docking sites for signalling proteins ...
Benedikt Asbach, Christine Ludwig, Kalle Saksela, Ralf Wagner   +3 more
doaj   +1 more source

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain [PDF]

Journal of Biological Chemistry, 1995
Signaling for cell death by Fas/APO1 occurs via a distinct region in its intracellular domain. This region contains a conserved sequence motif, the death domain motif, that is also found in the intracellular domains of the p55 tumor necrosis factor receptor and the low affinity nerve growth factor receptor, as well as in the regulatory domain of the ...
M P, Boldin, E E, Varfolomeev, Z, Pancer, I L, Mett, J H, Camonis, D, Wallach   +5 more
openaire   +2 more sources

Calcium binding activity of the epidermal growth factor-like domains of the apicomplexan microneme protein EtMIC4 [PDF]

, 2005
Microneme proteins are secreted from apicomplexan parasites during invasion of host cells and they play crucial roles in parasite-host cell adhesion.
Gill, A C, Knott, V, Tomley, F M, Periz, J, Tomley, FM, Handford, P A, Gill, AC, Handford, Penelope, Handford, PA   +8 more
core   +1 more source

Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses

Computational and Structural Biotechnology Journal, 2021
Viruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the receptor-binding motifs ...
Christopher A. Beaudoin, Arian R. Jamasb, Ali F. Alsulami, Liviu Copoiu, Andries J. van Tonder, Sharif Hala, Bridget P. Bannerman, Sherine E. Thomas, Sundeep Chaitanya Vedithi, Pedro H.M. Torres, Tom L. Blundell   +10 more
doaj   +1 more source