Results 271 to 280 of about 2,229,273 (315)

Protein-Protein Interactions of Phosphodiesterases

Current Topics in Medicinal Chemistry, 2019
Background: Phosphodiesterases (PDEs) are enzymes that play a key role in terminating cyclic nucleotides signalling by catalysing the hydrolysis of 3’, 5’- cyclic adenosine monophosphate (cAMP) and/or 3’, 5’ cyclic guanosine monophosphate (cGMP), the second messengers within the cell that transport the signals produced by extracellular signalling ...
Mayasah Y, Al-Nema, Anand, Gaurav
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Decoding Protein-protein Interactions: An Overview

Current Topics in Medicinal Chemistry, 2020
Drug discovery has focused on the paradigm “one drug, one target” for a long time. However, small molecules can act at multiple macromolecular targets, which serves as the basis for drug repurposing. In an effort to expand the target space, and given advances in X-ray crystallography, protein-protein interactions have become an emerging focus area of ...
Olivia Slater, Bethany Miller, Maria Kontoyianni   +2 more
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Protein-Protein Interactions in TRAF3

2007
TNF-receptor-associated factors (TRAFs) are intracellular proteins that bind to the cytoplasmic portion of TNF receptors and mediate downstream signaling. The six known TRAF proteins play overlapping yet distinct roles in controlling immune responses as well as cellular processes such as activation of NF-kappaB and JNK signaling pathways.
Kathryn R, Ely, Ramadurgam, Kodandapani, ShuangDing, Wu   +2 more
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Analyzing Protein–Protein Interaction Networks

Journal of Proteome Research, 2012
The advent of the "omics" era in biology research has brought new challenges and requires the development of novel strategies to answer previously intractable questions. Molecular interaction networks provide a framework to visualize cellular processes, but their complexity often makes their interpretation an overwhelming task.
Koh GC, Porras P, Aranda B, Hermjakob H, Orchard SE.   +4 more
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Protein-Protein Interactions

1954
Publisher Summary This chapter focuses on protein–protein interaction. The unique characteristics of different proteins are developed in the interactions of proteins with each other, with ions, and with nonprotein materials such as lipids, nucleic acids, and carbohydrates.
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Protein–Protein Interactions as Drug Targets

Future Medicinal Chemistry, 2015
Modulation of protein-protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this 'target class' was deemed to be largely undruggable an impressing number of publications and success stories now show that targeting PPIs with small, drug-like molecules indeed is a feasible approach ...
Skwarczynska, Malgorzata, Ottmann, Christian   +1 more
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Protein-Protein Interaction Databases

2015
Years of meticulous curation of scientific literature and increasingly reliable computational predictions have resulted in creation of vast databases of protein interaction data. Over the years, these repositories have become a basic framework in which experiments are analyzed and new directions of research are explored.
Szklarczyk, Damian, Jensen, Lars Juhl
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Analysis of Protein‐Protein Interactions

Current Protocols in Protein Science, 1998
AbstractThis overview defines some of the terminology used in the study of protein‐protein interactions and also describes the basis of equilibrium kinetic assays (i.e., defining necessary assumptions, terms and equations).
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Drugs Targeting Protein—Protein Interactions

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Structural Basis of Protein–Protein Interactions

2004
Regulated interactions between proteins govern signaling pathways within and between cells. Although it is possible to derive some general principles of protein-protein recognition from experimentally determined structures, recent structural studies on protein complexes formed during signal transduction illustrate the remarkable diversity of ...
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