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Protein–Protein Interactions as Drug Targets
Future Medicinal Chemistry, 2015Modulation of protein-protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this 'target class' was deemed to be largely undruggable an impressing number of publications and success stories now show that targeting PPIs with small, drug-like molecules indeed is a feasible approach ...
Skwarczynska, Malgorzata +1 more
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Protein-Protein Interaction Databases
2015Years of meticulous curation of scientific literature and increasingly reliable computational predictions have resulted in creation of vast databases of protein interaction data. Over the years, these repositories have become a basic framework in which experiments are analyzed and new directions of research are explored.
Szklarczyk, Damian, Jensen, Lars Juhl
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Analysis of Protein‐Protein Interactions
Current Protocols in Protein Science, 1998AbstractThis overview defines some of the terminology used in the study of protein‐protein interactions and also describes the basis of equilibrium kinetic assays (i.e., defining necessary assumptions, terms and equations).
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Drugs Targeting Protein—Protein Interactions
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Structural Basis of Protein–Protein Interactions
2004Regulated interactions between proteins govern signaling pathways within and between cells. Although it is possible to derive some general principles of protein-protein recognition from experimentally determined structures, recent structural studies on protein complexes formed during signal transduction illustrate the remarkable diversity of ...
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2008
H. Guan, E. Kiss-Toth: Advanced Technologies for Studies on Protein Interactomes.- S.-Y. Shin, S.-M. Choo, S.-H. Woo, K.-H. Cho: Cardiac Systems Biology and Parameter Sensitivity Analysis: Intracellular Ca2+ Regulatory Mechanisms in Mouse Ventricular Myocytes.- T.G. Chappell, P.N. Gray: Protein Interactions: Analysis Using Allele Libraries.- M.
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H. Guan, E. Kiss-Toth: Advanced Technologies for Studies on Protein Interactomes.- S.-Y. Shin, S.-M. Choo, S.-H. Woo, K.-H. Cho: Cardiac Systems Biology and Parameter Sensitivity Analysis: Intracellular Ca2+ Regulatory Mechanisms in Mouse Ventricular Myocytes.- T.G. Chappell, P.N. Gray: Protein Interactions: Analysis Using Allele Libraries.- M.
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2000
Molecular chaperones are a group of proteins that bind to newly synthesized polypeptides or nonnative proteins caused by various stresses such as heat shock and which assist them to fold to the native structure by protecting them from aggregation.
Noriyuki Murai +6 more
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Molecular chaperones are a group of proteins that bind to newly synthesized polypeptides or nonnative proteins caused by various stresses such as heat shock and which assist them to fold to the native structure by protecting them from aggregation.
Noriyuki Murai +6 more
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An atlas of protein-protein interactions across mouse tissues
Cell, 2021Michael A Skinnider +2 more
exaly
1993
Proteins exist in the cellular aqueous environment containing carbohydrate, lipid, nucleic acids and other proteins. While soluble proteins interact with their substrate in a three-dimensional matrix, a number of the cellular proteins exist in a membranous structure, located as components of one or another of the cellular membranes.
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Proteins exist in the cellular aqueous environment containing carbohydrate, lipid, nucleic acids and other proteins. While soluble proteins interact with their substrate in a three-dimensional matrix, a number of the cellular proteins exist in a membranous structure, located as components of one or another of the cellular membranes.
openaire +1 more source